Hippo Pathway Drives Durable Non‐Cell‐Autonomous Ferroptosis Resistance in Lung Cancer
YAP/TAZ, key effectors in lung cancer progression, paradoxically sensitize tumor cells to ferroptosis. This study reveals that YAP/TAZ‐low cells confer non‐cell‐autonomous, GCH1‐mediated durable ferroptosis resistance to neighboring YAP/TAZ‐high cells via a soluble factor, highlighting a Hippo pathway‐linked mechanism of tumor adaptation and survival ...
Mohamed Fathi Saleh +6 more
wiley +1 more source
Disulfidptosis and its emerging relevance in cancer and immunity. [PDF]
Li Q, Wu S, Zhuang L, Gan B.
europepmc +1 more source
Insights Into Macrophage Ferroptosis: Implications for Atherosclerosis
Macrophage ferroptosis drives atherosclerosis by enhancing oxidative stress and inflammation, accelerating plaque progression and instability. Targeting macrophage ferroptosis presents a promising therapeutic strategy for atherosclerosis treatment.
Xiehui Chen, Xiangbo Liu, Changchun Zeng
wiley +1 more source
Metabolic interplay between exogenous cystine and glutamine dependence in triple-negative breast cancer. [PDF]
Ge Z +5 more
europepmc +1 more source
ALDH2 Mediated Ferroptosis Regulation in Ischemia–Reperfusion Injury
ABSTRACT Ischemia–reperfusion injury (IRI) is a common complication in diverse clinical settings, including myocardial infarction, stroke, organ transplantation and major surgery. Its pathological core lies in the metabolic disruption caused by blood flow cessation, followed by oxidative stress, inflammatory cascades and cell death upon reperfusion ...
Liang Han, Wen Zhai
wiley +1 more source
CAPZA1 deficiency disrupts sperm flagellar structure and motility, potentially involving the p300/SLC7A11 pathway. [PDF]
Lu H +6 more
europepmc +1 more source
Summary Coexpression of genes involved in carbon (C) and nitrogen (N) metabolism offers a promising avenue for improving crop yield. This study investigated the impact of coexpressing phosphoenolpyruvate carboxylase [ZmPEPC (P)], aspartate aminotransferase [GmAspAT (A)] and glutamine synthetase [NtGS (G)] in Brassica juncea to enhance plant yield ...
Mamta +5 more
wiley +1 more source
In Vivo Radiographic Characteristics Associated With the Mineral Composition of Calcium Oxalate, Struvite, and Cystine Lower Urinary Tract Uroliths in Dogs. [PDF]
Pulido Vega D +3 more
europepmc +1 more source
Growth environment strongly influences green coffee bean biochemistry, linking phytochemical composition to adaptation under abiotic stress. Abstract This study explores how bioactive compounds in green coffee beans (Coffea arabica L.) vary across different geographic regions, addressing the key question of how environmental factors shape coffee ...
I. Pettazzoni +6 more
wiley +1 more source
Acquired cystinuria in a kidney transplant recipient. [PDF]
Martin C +6 more
europepmc +1 more source

