Results 71 to 80 of about 47,323 (291)
Animal Models and Experimental Medicine, EarlyView.BSN suppresses the cell viability of colorectal cancer by inducing GPX4‐regulated ferroptosis. BSN may bind to NRF2 protein to inactivate the NRF2 signaling, inhibiting the expression of p62 and HO‐1. Abstract Background Indole phytoalexins, plant‐derived compounds present in cruciferous vegetables, have demonstrated anticancer properties.
Shi‐Yuan Wen +5 more
wiley +1 more source
Cerebrospinal Fluid Metabolome in Central Nervous System Infections: A Study of Diagnostic Accuracy
Annals of Neurology, EarlyView.Objective To assess the diagnostic accuracy of metabolites in cerebrospinal fluid (CSF) for central nervous system (CNS) infections. Methods Patients were derived from three prospective cohort studies in the Netherlands. All studies included adults suspected of a CNS infection who underwent a diagnostic lumbar puncture.
Steven L. Staal +7 more
wiley +1 more source
European Journal of Medical Research, 2012 Cystine stones, the main component of which is cystine, are very common urinary calculi, but are rare in the gall bladder. In animals, there has been only one report of cystine gallstones in tree shrews, and to our knowledge, this is the first report of ...
Qiao Tie +6 more
doaj +1 more source
Scaffolding of Cystine‐Stabilized Miniproteins
ChemistrySelect, 2016 AbstractBiomolecular scaffolds were engineered by genetically fusing robust miniproteins in a sequence, like a chain. By fusing these miniprotein chains to a teal fluorescent protein (TFP), an efficient strategy was devised for their production in E. coli.
Arjan Barendregt +7 more
openaire +4 more sources
Angewandte Chemie International Edition, Accepted Article.Achieving modular, selective and homogeneous protein modifications is of utmost importance for the design of next generation biopharmaceuticals; especially in the context of antibody‐drug conjugates (ADCs). Here, we introduce unsaturated phosphine oxides as versatile triple‐reactive reagents, allowing orthogonal chemoselective bioconjugation schemes ...
Christian E. Stieger +5 more
wiley +1 more source
Chemically Synthesized LRAD3‐D1 Interacts with N‐terminal Domain of SARS‐CoV‐2 Spike Protein
ChemBioChem, Accepted Article.Growing evidence of post‐COVID neurological complications, such as encephalopathy, neurodegeneration, and cognitive impairment, suggests SARS‐CoV‐2 viral infection into the central nervous system (CNS). Therefore, understanding the mechanisms of viral entry into the CNS, where human angiotensin‐converting enzyme 2 is barely expressed, is critical for ...
Mrinmoy Jana +5 more
wiley +1 more source
The Fanconi syndrome of cystinosis: insights into the pathophysiology
The Turkish Journal of Pediatrics, 2002 Cystinosis is a lysosomal storage disease, and is one of the most common causes of the Fanconi syndrome. In vitro studies of the cystine-loaded tubule provided insights into the pathophysiology of the proximal tubular defect.
Abdullah Sakarcan
doaj +1 more source
Effect of cystine loading and cystine dimethylester on renal brushborder membrane transport
Bioscience Reports, 1990 The effect of loading renal tubule cells with cystine was studied by incubating them with cystine dimethylester. Proline uptake into brushborder membrane vesicles isolated from the cystine loaded cells was not different from that observed into brushborder vesicles isolated from tubules incubated in buffer alone.
John W. Foreman, Linda L. Benson
openaire +3 more sources
Electroenzymatic CO2 Reduction Using Formate Dehydrogenase: Direct and Mediated Catalysis
ChemElectroChem, EarlyView.Formate dehydrogenase from Desulfovibrio desulfuricans (DdFDH) demonstrates the ability to reversibly catalyze the electrochemical reduction of CO2 into formate, offering a potential pathway for CO2 mitigation and production of value‐added compounds.
Navendu Paul +4 more
wiley +1 more source
ChemPlusChem, EarlyView.New catechol derivatives are found to inhibit the urease enzyme more effectively than N‐(n‐butyl)thiophosphoric triamide (NBPT), particularly in acidic sandy loam soil. Unlike NBPT, these derivatives exert their inhibitory effect through noncompetitive inhibition.
Joses G. Nathanael +2 more
wiley +1 more source