Results 151 to 160 of about 16,026 (192)

Human Cytidine Deaminase: Understanding the Catalytic Mechanism

Nucleosides, Nucleotides and Nucleic Acids, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
COSTANZI S, VINCENZETTI, Silvia, VITA, Alberto, LAMBERTUCCI, Catia, TAFFI S, VOLPINI, Rosaria, VITTORI, Sauro, CRISTALLI, Gloria   +7 more
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Crystal structure of Arabidopsis thaliana cytidine deaminase

Biochemical and Biophysical Research Communications, 2020
Cytidine deaminase (CDA) catalyzes the (deoxy)cytidine deamination to (deoxy)uridine, which involves in the catabolic and salvage pathways of pyrimidine nucleotides in plants. CDA serves as a prototype of the cytidine deaminase superfamily that contains a number of RNA editing enzymes. Arabidopsis thaliana has only one functional CDA, AtCDA1. We solved
Jia Wang, Qi Guo, Lin Liu, Xiao Wang
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Activity of serum cytidine deaminase during pregnancy

BJOG: An International Journal of Obstetrics & Gynaecology, 1982
Summary. A simple and reliable method for the estimation of cytidine deaminase (cytidine aminohydrolase; EC 3.5.4.5) activity in pregnancy serum is described. This enzyme does not require magnesium for activation and is also more stable than deoxycytidylate deaminase (dCMP deaminase, dCMP aminohydrolase; EC 3.5.4.12).
D D, Jones, S, Bahijri, E L, Roberts, G F, Williams   +3 more
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Cytidine and deoxycytidylate deaminase inhibition by uridine analogs

Biochemical Pharmacology, 1980
Cytidine deaminase, an enzyme found in the supernatant fluid of hepatocytes, granulocytes and tumor cells, and in plasma, degrades the antitumor agents cytosine arabinoside and 5-azacytidine. Uridine and its analogs, 3-deazauridine, 5-bromodeoxyuridine, 5-fluorodeoxyuridine and 6-azauridine, were found to competitively inhibit cytidine deaminase; the ...
J C, Drake, K R, Hande, R W, Fuller, B A, Chabner   +3 more
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Multifaceted antiviral actions of APOBEC3 cytidine deaminases

Trends in Immunology, 2006
To defend against external pathogens, metazoan organisms have evolved numerous defenses that generally fall within the innate and adaptive immune responses. Considerable effort continues to focus on developing a vaccine to manipulate the adaptive immune system to protect against or control HIV-1.
Ya-Lin, Chiu, Warner C, Greene
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The role of activation-induced cytidine deaminase in lymphomagenesis

Current Opinion in Hematology, 2012
Activation-induced cytidine deaminase (AID) is expressed in germinal center B cells and initiates the events that lead to somatic hypermutation and class switch recombination of immunoglobulin genes. In addition to this fundamental role in immune diversification, aberrant targeting of AID activity contributes to point mutations and translocations of ...
Xiwen, Gu, Velizar, Shivarov, Matthew P, Strout   +2 more
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On the Role of Cytidine Deaminase in Cellular Metabolism

1986
Pyrimidine nucleotides are synthesized either denovo or via salvage pathways from preformed pyrimidine compounds. The denovo pathway of UTP and CTP synthesis appears to be almost identical in the various organisms studied, while there are major differences in the pathways by which pyrimidine deoxynu-cleotides are synthesized.
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Determination of plasma cytidine deaminase activity by HPLC

Biomedical Chromatography, 1987
AbstractCytidine deaminase is an enzyme of nucleic acid metabolism, the measurement of which has been proposed as a useful test for the early detection of pre‐eclamptic toxaemia in pregnancy. The enzyme converts the nucleoside cytidine to uridine, with the release of ammonia, and it is the measurement of this latter compound that forms the basis of the
D A, Richards, R A, Sherwood, D, Ndebele, B F, Rocks   +3 more
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Base editing with a Cpf1–cytidine deaminase fusion

Nature Biotechnology, 2018
The targeting range of CRISPR-Cas9 base editors (BEs) is limited by their G/C-rich protospacer-adjacent motif (PAM) sequences. To overcome this limitation, we developed a CRISPR-Cpf1-based BE by fusing the rat cytosine deaminase APOBEC1 to a catalytically inactive version of Lachnospiraceae bacterium Cpf1.
Xiaosa Li, Ying Wang, Yajing Liu, Bei Yang, Xiao Wang, Jia Wei, Zongyang Lu, Yuxi Zhang, Jing Wu, Xingxu Huang, Li Yang, Jia Chen   +11 more
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Hypermutation by intersegmental transfer of APOBEC3G cytidine deaminase

Nature Structural & Molecular Biology, 2008
Deamination of cytidine residues in single-stranded DNA (ssDNA) is an important mechanism by which apolipoprotein B mRNA-editing, catalytic polypeptide-like (APOBEC) enzymes restrict endogenous and exogenous viruses. The dynamic process underlying APOBEC-induced hypermutation is not fully understood.
Roni, Nowarski, Elena, Britan-Rosich, Tamar, Shiloach, Moshe, Kotler   +3 more
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