Results 131 to 140 of about 30,296 (276)

Az Interferon-gamma által indukált jelátvitel mechanizmusa humán újszülöttek mononukleáris fagocitasejtjeiben = Interferon-gamma induced signaling in mononuclear phagocytes from human neonates [PDF]

, 2006
Humán újszülöttek és felnőttek mononukleáris (MN) fagocitasejtjeiben a foszforilált STAT-1 kimutatásához olyan monoclonalis antitesteket használtunk, amelyek specifikusan kötődnek a foszforilált STAT-1 molekulákhoz, de nem kötődnek a natív STAT-1 ...
Erdős, Melinda, Gócs, Viktor, Maródi, László, Nemes, Éva, Palicz, Anita   +4 more
core  

A circuitous route for in vitro multi-enzyme cascade production of cytidine triphosphate to overcome the thermodynamic bottleneck

Bioresources and Bioprocessing
Cytidine triphosphate (CTP), as a substance involved in the metabolism of phospholipids, proteins and nucleic acids, has precise drug effects and is a direct precursor for the synthesis of drugs such as citicoline.
Zonglin Li, Yahui Zhong, Zhoulei Qing, Zhimin Li   +3 more
doaj   +1 more source

In vivo RNA editing of point mutations via RNA-guided adenosine deaminases. [PDF]

, 2019
We present in vivo sequence-specific RNA base editing via adenosine deaminases acting on RNA (ADAR) enzymes with associated ADAR guide RNAs (adRNAs). To achieve this, we systematically engineered adRNAs to harness ADARs, and comprehensively evaluated the
Chen, Genghao, Ganesh, Ashwin, Katrekar, Dhruva, Mali, Prashant, Meluzzi, Dario, Shih, Yu-Ru, Varghese, Shyni, Worlikar, Atharv   +7 more
core   +1 more source

Lamarck and immunity: Somatic and germline evolution of antibody genes [PDF]

, 2009
Current work on the mechanism of hypermutation of somatically rearranged antibody variable (V) genes shows that the most likely mechanism involves both direct DNA modification (deamination of cytosines to uracils by AID deaminase) and strand nicking plus
Steele, E.J.
core   +1 more source

Molecular mechanism for regulating APOBEC3G DNA editing function by the non-catalytic domain

Nature Communications
APOBEC3G, part of the AID/APOBEC cytidine deaminase family, is crucial for antiviral immunity. It has two zinc-coordinated cytidine-deaminase domains.
Hanjing Yang, Josue Pacheco, Kyumin Kim, Ayub Bokani, Fumiaki Ito, Diako Ebrahimi, Xiaojiang S. Chen   +6 more
doaj   +1 more source

Cytidine Deaminase [PDF]

, 2020
openaire   +1 more source

Activation-induced cytidine deaminase an antibody diversification enzyme interacts with chromatin modifier UBN1 in B-cells. [PDF]

Sci Rep, 2023
Jaiswal A, Roy R, Tamrakar A, Singh AK, Kar P, Kodgire P.   +5 more
europepmc   +1 more source

De novo protein synthesis is required for activation-induced cytidine deaminase-dependent DNA cleavage in immunoglobulin class switch recombination

, 2004
Nasim A. Begum, Kazuo Kinoshita, Masamichi Muramatsu, Hitoshi Nagaoka, Reiko Shinkura, Tasuku Honjo   +5 more
openalex   +2 more sources

Evolution of vertebrate adaptive immunity: Immune cells and tissues, and AID/APOBEC cytidine deaminases [PDF]

, 2015
Masayuki Hirano
openalex   +1 more source

Upregulation of cytidine deaminase in NAT1 knockout breast cancer cells. [PDF]

J Cancer Res Clin Oncol, 2023
Hong KU, Tagnedji AH, Doll MA, Walls KM, Hein DW.   +4 more
europepmc   +1 more source