Molecular mechanisms of cytoadherence in malaria
American Journal of Physiology-Cell Physiology, 1999 Microbial pathogens subvert host adhesion molecules to disseminate or to enter host cells to promote their own survival. One such subversion is the cytoadherence of Plasmodium falciparum-infected erythrocytes (IRBC) to vascular endothelium, which protects the parasite from being removed by the spleen.
May, H, White, N
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The influence of host genetics on erythrocytes and malaria infection: is there therapeutic potential? [PDF]
, 2015 As parasites, Plasmodium species depend upon their host for survival. During the blood stage of their life-cycle parasites invade and reside within erythrocytes, commandeering host proteins and resources towards their own ends, and dramatically ...
Burgio, Gaetan +3 more
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Memorias do Instituto Oswaldo Cruz, 2014 In the Amazon Region, there is a virtual absence of severe malaria and few fatal cases of naturally occurring Plasmodium falciparum infections; this presents an intriguing and underexplored area of research.
Alessandra Sampaio Bassi Fratus +9 more
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Vivax Malaria and the Potential Role of the Subtelomeric Multigene vir Superfamily
Microorganisms, 2022 Vivax malaria, caused by Plasmodium vivax, remains a public health concern in Central and Southeast Asia and South America, with more than two billion people at risk of infection. Compared to Plasmodium falciparum, P.
Youn-Kyoung Goo
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Severe malaria - a case of fatal Plasmodium knowlesi infection with post-mortem findings: a case report. [PDF]
, 2010 BACKGROUND: Zoonotic malaria caused by Plasmodium knowlesi is an important, but newly recognized, human pathogen. For the first time, post-mortem findings from a fatal case of knowlesi malaria are reported here.
Adem, P +10 more
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Broad inhibition of plasmodium falciparum cytoadherence by (+)-epigallocatechin gallate [PDF]
Malaria Journal, 2011 Abstract Background The surface antigen Pf EMP-1 is a key virulence factor of the human malaria parasite implicated in the cytoadherence of Plasmodium falciparum infected erythrocytes to a range of receptors on host endothelium. Among these host receptors, binding to ICAM-1 is related to cerebral malaria. The majority
Patil, Pradeep R. +3 more
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Optimization and inhibition of the adherent ability of Plasmodium falciparum-infected erythrocytes
Memorias do Instituto Oswaldo Cruz, 1992 The vast majority of the 1-2 million malaria associated deaths that occur each year are due to anemia and cerebral malaria (the attachment of erythrocytes containing mature forms of Plasmodium falciparum to the endothelial cells that line the vascular ...
Heidi Smith +3 more
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An Analysis of the Binding Characteristics of a Panel of Recently Selected ICAM-1 Binding Plasmodium falciparum Patient Isolates. [PDF]
, 2014 The basis of severe malaria pathogenesis in part includes sequestration of Plasmodium falciparum-infected erythrocytes (IE) from the peripheral circulation.
Alharthi, Saeed +9 more
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Antimalarial Drugs Reduce Cytoadherence and Rosetting of Plasmodium falciparum [PDF]
Journal of Infectious Diseases, 1996 The in vivo and in vitro effects of antimalarials on cytoadherence and rosette formation were studied in 17 patients with severe and 46 with uncomplicated falciparum malaria. Cytoadherence was increased in severe malaria (P50% inhibition of both cytoadherence and rosetting in vivo and in vitro within 2 hr of drug exposure. Exposure to quinine for > or =
Udomsangpetch, R +8 more
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Cerebral malaria is associated with differential cytoadherence to brain endothelial cells
EMBO Molecular Medicine, 2019 Sequestration of Plasmodium falciparum‐infected erythrocytes (IE) within the brain microvasculature is a hallmark of cerebral malaria (CM). Using a microchannel flow adhesion assay with TNF‐activated primary human microvascular endothelial cells, we ...
Janet Storm +11 more
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