Role of α-Actinin 2 in Cytoadherence and Cytotoxicity of Trichomonas vaginalis.
Journal of Microbiology and Biotechnology, 2017 Trichomonas vaginalis is a pathogen that triggers severe immune responses in hosts. T. vaginalis α-actinin 2 (Tvα-actinin 2) has been used to diagnose trichomoniasis.
H. Lee, Juri Kim, Soon-Jung Park
semanticscholar +6 more sources
Ex-vivo cytoadherence phenotypes of Plasmodium falciparum strains from Malian children with hemoglobins A, S, and C. [PDF]
PLoS ONE, 2014 Sickle hemoglobin (Hb) S and HbC may protect against malaria by reducing the expression of Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) on the surface of parasitized red blood cells (RBCs), thereby weakening their cytoadherence to ...
Jeanette T Beaudry +7 more
doaj +3 more sources
A semi-synthetic glycosaminoglycan analogue inhibits and reverses Plasmodium falciparum cytoadherence [PDF]
PLOS ONE, 2017 A feature of mature Plasmodium falciparum parasitized red blood cells is their ability to bind surface molecules of the microvascular endothelium via the parasite-derived surface protein Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1). This
M. Skidmore +5 more
semanticscholar +7 more sources
Cell Discovery, 2021 Pregnancy Associated Malaria (PAM) threatens more than one million pregnant women and their infants in endemic regions due to poor outcomes. VAR2CSA plays a vital role in the cytoadherence of infected erythrocytes (IEs) to placenta against immuno ...
Weiwei Wang +17 more
semanticscholar +2 more sources
Signal transduction in Plasmodium-Red Blood Cells interactions and in cytoadherence [PDF]
Anais da Academia Brasileira de Ciências, 2012 Malaria is responsible for more than 1.5 million deaths each year, especially among children (Snow et al. 2005). Despite of the severity of malaria situation and great effort to the development of new drug targets (Yuan et al.
Laura N. Cruz +3 more
doaj +7 more sources
Frontiers in Molecular Biosciences, 2022 Plasmodium falciparum is responsible for the most severe and deadliest human malaria infection. The most serious complication of this infection is cerebral malaria.
Michael Oluwatoyin Daniyan +2 more
doaj +1 more source
Multi-epitope-Based Vaccine Designed by Targeting Cytoadherence Proteins of Mycoplasma gallisepticum
ACS Omega, 2021 Mycoplasma gallisepticum causes chronic respiratory disease in chickens leading to large economic losses in the poultry industry, and the impacts remain to be a great challenge for a longer period.
Susithra Priyadarshni Mugunthan +1 more
semanticscholar +1 more source
Pathophysiology of Cerebral Malaria: Implications of MSCs as A Regenerative Medicinal Tool
Bioengineering, 2022 The severe form of malaria, i.e., cerebral malaria caused by Plasmodium falciparum, is a complex neurological syndrome. Surviving persons have a risk of behavioral difficulties, cognitive disorders, and epilepsy.
Amrendra Chaudhary +3 more
doaj +1 more source
Antibodies to specific domains of Plasmodium falciparum erythrocyte membrane protein-1 and its relationship with protection from severe malarial anemia: A prospective study among Ghanaian children. [PDF]
Health Sci RepAbstract Background Plasmodium falciparum erythrocyte membrane protein‐1 (PfEMP‐1) is important in malaria pathogenicity as it mediates Pf‐infected erythrocytes cytoadherence to host endothelial microvasculature receptors. Naturally acquired antibodies against specific PfEMP‐1 antigens may be beneficial in clinical malaria protection.
Nkansah C +17 more
europepmc +2 more sources
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Mature asexual stages of Plasmodium falciparum-infected erythrocytes (IEs) bind to endothelium to avoid splenic clearance. The PfEMP1 family is the major cytoadhesion ligand at the IE surface and is essential for parasite sequestration.
Yvonne Azasi +11 more
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