Association of severe malaria outcomes with platelet-mediated clumping and adhesion to a novel host receptor. [PDF]
PLoS ONE, 2011 IntroductionSevere malaria has been attributed partly to the sequestration of Plasmodium falciparum-infected erythrocytes (IEs) in the microvasculature of vital host organs. Identification of P.
Alfredo Mayor +11 more
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The bacterial protein CNF1 as a new strategy against Plasmodium falciparum cytoadherence.
PLoS ONE, 2019 Plasmodium falciparum severe malaria causes more than 400,000 deaths every year. One feature of P. falciparum-parasitized erythrocytes (pRBC) leading to cerebral malaria (CM), the most dangerous form of severe malaria, is cytoadherence to endothelium and
Valeria Messina +9 more
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Virulence and the immune response in malaria
Memorias do Instituto Oswaldo Cruz, 1992 Many factors determine the virulence of a malaria infection. These include host innate resistance mechanisms and, with Plasmodium falciparum, the ability to cytoadhere to endothelial cells, form rosetts, and induce release of cytokines.
G. A. T. Targett
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Ex-vivo cytoadherence phenotypes of Plasmodium falciparum strains from Malian children with hemoglobins A, S, and C. [PDF]
PLoS ONE, 2014 Sickle hemoglobin (Hb) S and HbC may protect against malaria by reducing the expression of Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) on the surface of parasitized red blood cells (RBCs), thereby weakening their cytoadherence to ...
Jeanette T Beaudry +7 more
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Frontiers in Cellular and Infection MicrobiologyCerebral malaria is the most severe and lethal complication caused by Plasmodium falciparum infection, leading to critical neurological impairments and long-term cognitive, behavioral, and neurological sequelae in survivors, particularly affecting ...
Renato M. S. de Lima +6 more
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On cytoadhesion of Plasmodium vivax: raison d'être?
Memorias do Instituto Oswaldo Cruz, 2011 It is generally accepted that Plasmodium vivax, the most widely distributed human malaria parasite, causes mild disease and that this species does not sequester in the deep capillaries of internal organs.
Fabio TM Costa +10 more
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A chromosome 9 deletion in Plasmodium falciparum results in loss of cytoadherence
Memorias do Instituto Oswaldo Cruz, 1992 Many lines of Plasmodium falciparum undrgo a deletion of the right end of chromosome 9 during in vitro culture accompanied by loss of cytoadherence and gametocytogenesis.
D. J. Kemp +7 more
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Molecular mechanistic insights into the endothelial receptor mediated cytoadherence of Plasmodium falciparum-infected erythrocytes. [PDF]
PLoS ONE, 2011 Cytoadherence or sequestration is essential for the pathogenesis of the most virulent human malaria species, Plasmodium falciparum (P. falciparum). Similar to leukocyte-endothelium interaction in response to inflammation, cytoadherence of P.
Ang Li +8 more
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Mycobacterial laminin-binding histone-like protein mediates collagen-dependent cytoadherence
Memorias do Instituto Oswaldo Cruz, 2012 When grown in the presence of exogenous collagen I, Mycobacterium bovis BCG was shown to form clumps. Scanning electron microscopy examination of these clumps revealed the presence of collagen fibres cross-linking the bacilli.
André Alves Dias +8 more
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High plasma levels of soluble intercellular adhesion molecule (ICAM)-1 are associated with cerebral malaria. [PDF]
PLoS ONE, 2013 BackgroundCerebral malaria (CM) is responsible for most of the malaria-related deaths in children in sub-Saharan Africa. Although, not well understood, the pathogenesis of CM involves parasite and host factors which contribute to parasite sequestration ...
Selorme Adukpo +10 more
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