Results 11 to 20 of about 2,810 (108)

Transcriptional responses of brain endothelium to Plasmodium falciparum patient-derived isolates in vitro [PDF]

Microbiology Spectrum
A hallmark of cerebral malaria (CM) is sequestration of Plasmodium falciparum-infected erythrocytes (IE) within the brain microvasculature. Binding of IE to endothelium reduces microvascular flow and, combined with an inflammatory response, perturbs ...
Caroline Askonas, Janet Storm, Grazia Camarda, Alister Craig, Arnab Pain   +4 more
doaj   +2 more sources

Computational Insights into the Interaction between Cytoadherence Receptor gC1qR and the DBLβ12 Domain of a Plasmodium falciparum PfEMP1 Ligand

Life, 2021
Human receptor gC1qR is a 32 kD protein that mediates the cytoadherence of Plasmodium falciparum-infected erythrocytes (IEs) to human brain microvascular endothelial cells (HBMEC) and platelets.
Rowaida Bakri, Mohd Rehan, Hina Shamshad, Abdul Hafiz   +3 more
doaj   +1 more source

Pathophysiology of Cerebral Malaria: Implications of MSCs as A Regenerative Medicinal Tool

Bioengineering, 2022
The severe form of malaria, i.e., cerebral malaria caused by Plasmodium falciparum, is a complex neurological syndrome. Surviving persons have a risk of behavioral difficulties, cognitive disorders, and epilepsy.
Amrendra Chaudhary, Poonam Kataria, Neha Surela, Jyoti Das   +3 more
doaj   +1 more source

Neurotransmitters and molecular chaperones interactions in cerebral malaria: Is there a missing link?

Frontiers in Molecular Biosciences, 2022
Plasmodium falciparum is responsible for the most severe and deadliest human malaria infection. The most serious complication of this infection is cerebral malaria.
Michael Oluwatoyin Daniyan, Funmilola Adesodun Fisusi, Olufunso Bayo Adeoye   +2 more
doaj   +1 more source

The delayed bloodstream clearance of Plasmodium falciparum parasites after M5717 treatment is attributable to the inability to modify their red blood cell hosts

Frontiers in Cellular and Infection Microbiology, 2023
M5717 is a promising antimalarial drug under development that acts against multiple stages of the life cycle of Plasmodium parasites by inhibiting the translation elongation factor 2 (PfeEF2), thereby preventing protein synthesis.
Molly Parkyn Schneider, Oliver Looker, Maria Rebelo, David S. Khoury, Matthew W. A. Dixon, Claude Oeuvray, Brendan S. Crabb, Brendan S. Crabb, Brendan S. Crabb, James McCarthy, Paul R. Gilson, Paul R. Gilson   +11 more
doaj   +1 more source

Effects of sevuparin on rosette formation and cytoadherence of Plasmodium falciparum infected erythrocytes. [PDF]

PLoS ONE, 2017
In severe falciparum malaria cytoadherence of parasitised red blood cells (PRBCs) to vascular endothelium (causing sequestration) and to uninfected red cells (causing rosette formation) contribute to microcirculatory flow obstruction in vital organs ...
Somporn Saiwaew, Juntima Sritabal, Nattaporn Piaraksa, Srisuda Keayarsa, Ronnatrai Ruengweerayut, Chirapong Utaisin, Patima Sila, Rangsan Niramis, Rachanee Udomsangpetch, Prakaykaew Charunwatthana, Emsri Pongponratn, Sasithon Pukrittayakamee, Anna M Leitgeb, Mats Wahlgren, Sue J Lee, Nicholas P J Day, Nicholas J White, Arjen M Dondorp, Kesinee Chotivanich   +18 more
doaj   +1 more source

Cerebral Malaria and Neuronal Implications of Plasmodium Falciparum Infection: From Mechanisms to Advanced Models

Advanced Science, 2022
Reorganization of host red blood cells by the malaria parasite Plasmodium falciparum enables their sequestration via attachment to the microvasculature.
Oscar Bate Akide Ndunge, Nicole Kilian, Mootaz M. Salman   +2 more
doaj   +1 more source

Variation in the cytoadherence characteristics of malaria parasites: is this a true virulence factor?

Memorias do Instituto Oswaldo Cruz, 1992
The sequestration of Plasmodium falciparum-infected erythrocytes to the endothelial cells of brain capillaries is believed to represent one of the determining factors in the pathogenesis of cerebral malaria.
J. D. Goldring, M. Hommel
doaj   +1 more source

PfEMP1 A-Type ICAM-1-Binding Domains Are Not Associated with Cerebral Malaria in Beninese Children

mBio, 2020
PfEMP1 is the major antigen involved in Plasmodium falciparum-infected erythrocyte sequestration in cerebrovascular endothelium. While some PfEMP1 domains have been associated with clinical phenotypes of malaria, formal associations between the ...
V. Joste, E. Guillochon, J. Fraering, B. Vianou, L. Watier, S. Jafari-Guemouri, M. Cot, S. Houzé, A. Aubouy, J. F. Faucher, N. Argy, G. I. Bertin   +11 more
doaj   +1 more source

Plasmodium falciparum secretome in erythrocyte and beyond

Frontiers in Microbiology, 2016
Plasmodium falciparum is the causative agent of deadly malaria disease. It is an intracellular eukaryote and completes its multi-stage life cycle spanning the two hosts viz, mosquito and human.
Rani eSoni, Drista eSharma, Tarun Kumar Bhatt   +2 more
doaj   +1 more source