Results 21 to 30 of about 2,810 (108)

Endothelial Protein C Receptor Could Contribute to Experimental Malaria-Associated Acute Respiratory Distress Syndrome

Journal of Immunology Research, 2019
The severity of Plasmodium falciparum malaria is associated with parasite cytoadherence, but there is limited knowledge about the effect of parasite cytoadherence in malaria-associated acute respiratory distress syndrome (ARDS).
Luana dos Santos Ortolan, Michelle Klein Sercundes, Gabriel Candido Moura, Thatyane de Castro Quirino, Daniela Debone, Douglas de Sousa Costa, Oscar Murillo, Claudio Romero Farias Marinho, Sabrina Epiphanio   +8 more
doaj   +1 more source

Clinical and molecular aspects of severe malaria

Anais da Academia Brasileira de Ciências, 2005
The erythrocytic cycle of Plasmodium falciparum presents a particularity in relation to other Plasmodium species that infect man. Mature trophozoites and schizonts are sequestered from the peripheral circulation due to adhesion of infected erythrocytes ...
Karin Kirchgatter, Hernando A. Del Portillo   +1 more
doaj   +1 more source

Vivax Malaria and the Potential Role of the Subtelomeric Multigene vir Superfamily

Microorganisms, 2022
Vivax malaria, caused by Plasmodium vivax, remains a public health concern in Central and Southeast Asia and South America, with more than two billion people at risk of infection. Compared to Plasmodium falciparum, P.
Youn-Kyoung Goo
doaj   +1 more source

Antibody recognition of Plasmodium falciparum infected red blood cells by symptomatic and asymptomatic individuals in the Brazilian Amazon

Memorias do Instituto Oswaldo Cruz, 2014
In the Amazon Region, there is a virtual absence of severe malaria and few fatal cases of naturally occurring Plasmodium falciparum infections; this presents an intriguing and underexplored area of research.
Alessandra Sampaio Bassi Fratus, Fernanda Janku Cabral, Wesley Luzetti Fotoran, Márcia Melo Medeiros, Bianca Cechetto Carlos, Rosimeire dalla Martha, Luiz Hildebrando Pereira da Silva, Stefanie Costa Pinto Lopes, Fabio Trindade Maranhão Costa, Gerhard Wunderlich   +9 more
doaj   +1 more source

Optimization and inhibition of the adherent ability of Plasmodium falciparum-infected erythrocytes

Memorias do Instituto Oswaldo Cruz, 1992
The vast majority of the 1-2 million malaria associated deaths that occur each year are due to anemia and cerebral malaria (the attachment of erythrocytes containing mature forms of Plasmodium falciparum to the endothelial cells that line the vascular ...
Heidi Smith, Ian Crandall, Jacques Prudhomme, Irwin Sherman   +3 more
doaj   +1 more source

N-Terminal Segment of TvCyP2 Cyclophilin from Trichomonas vaginalis Is Involved in Self-Association, Membrane Interaction, and Subcellular Localization

Biomolecules, 2020
In Trichomonas vaginalis (T. vaginalis), cyclophilins play a vital role in dislodging Myb proteins from the membrane compartment and leading them to nuclear translocation. We previously reported that TvCyP1 cyclophilin from T. vaginalis forms a dimer and
Sarita Aryal, Hong-Ming Hsu, Yuan-Chao Lou, Chien-Hsin Chu, Jung-Hsiang Tai, Chun-Hua Hsu, Chinpan Chen   +6 more
doaj   +1 more source

In vitro inhibition and reversal of Plasmodium falciparum cytoadherence to endothelium by monoclonal antibodies to ICAM-1 and CD36

Malaria Journal, 2017
Background Sequestration of parasitized red blood cells from the peripheral circulation during an infection with Plasmodium falciparum is caused by an interaction between the parasite protein PfEMP1 and receptors on the surface of host endothelial cells,
Khairul M. F. Mustaffa, Janet Storm, Megan Whittaker, Tadge Szestak, Alister G. Craig   +4 more
doaj   +1 more source

Comparison of apoptosis in human primary pulmonary endothelial cells and a brain microvascular endothelial cell line co-cultured with Plasmodium falciparum field isolates

BMC Infectious Diseases, 2017
Background Plasmodium falciparum infection can progress unpredictably to severe forms including respiratory distress and cerebral malaria. The mechanisms underlying the variable natural course of malaria remain elusive. Methods The cerebral microvascular
Jean Claude Biteghe Bi Essone, Nadine N’Dilimabaka, Julien Ondzaga, Jean Bernard Lekana-Douki, Dieudonné Nkoghe Mba, Philippe Deloron, Dominique Mazier, Frédrérick Gay, Fousseyni S. Touré Ndouo   +8 more
doaj   +1 more source

An image-based drug susceptibility assay targeting the placental sequestration of Plasmodium falciparum-infected erythrocytes. [PDF]

PLoS ONE, 2012
Placental malaria is a significant cause of all malaria-related deaths globally for which no drugs have been developed to specifically disrupt its pathogenesis.
Min-Je Ku, Fernando de M Dossin, Michael A E Hansen, Auguste Genovesio, Lawrence Ayong, Lucio H Freitas-Junior   +5 more
doaj   +1 more source

ICAM-1 is a key receptor mediating cytoadherence and pathology in the Plasmodium chabaudi malaria model

Malaria Journal, 2017
Background Parasite cytoadherence within the microvasculature of tissues and organs of infected individuals is implicated in the pathogenesis of several malaria syndromes. Multiple host receptors may mediate sequestration.
Deirdre A. Cunningham, Jing-wen Lin, Thibaut Brugat, William Jarra, Irene Tumwine, Garikai Kushinga, Jai Ramesar, Blandine Franke-Fayard, Jean Langhorne   +8 more
doaj   +1 more source