Results 1 to 10 of about 48,300 (266)

Cytochalasins from the Ash Endophytic Fungus <i>Nemania diffusa</i> DSM 116299. [PDF]

Molecules
The secondary metabolome of Nemania diffusa, isolated as an ash endophytic fungus, was analyzed in detail. From its cultures, a previously undescribed cytochalasin 1 was isolated using preparative HPLC, together with six known congeners: 18-dehydroxy ...
Demir Ö, Schmidt K, Schulz B, Stradal TEB, Surup F.   +4 more
europepmc   +2 more sources

Dereplication of Cytochalasans and Octaketides in Cytotoxic Extracts of Endophytic Fungi from Casearia arborea (Salicaceae)

Metabolites, 2022
Endophytes have been shown to be a source of novel drug prototypes. The Casearia genus is known for presenting cytotoxic clerodane diterpenes; however, there are few reports on secondary metabolites produced by its fungal microbiota. Thus, in the present
Augusto L. Santos, Marisa Ionta, Renato O. Horvath, Marisi G. Soares, Daniele O. Silva, Eunizinis S. Kawafune, Marcelo J. P. Ferreira, Patricia Sartorelli   +7 more
doaj   +1 more source

Bacterial Engulfment Mechanism Is Strongly Conserved in Evolution Between Earthworm and Human Immune Cells

Frontiers in Immunology, 2021
Invertebrates, including earthworms, are applied to study the evolutionarily conserved cellular immune processes. Earthworm immunocytes (so-called coelomocytes) are functionally similar to vertebrate myeloid cells and form the first line of defense ...
Bohdana Kokhanyuk, Kornélia Bodó, György Sétáló Jr, György Sétáló Jr, Péter Németh, Péter Engelmann   +5 more
doaj   +1 more source

Testing Strategies of the In Vitro Micronucleus Assay for the Genotoxicity Assessment of Nanomaterials in BEAS-2B Cells

Nanomaterials, 2021
The evaluation of the frequency of micronuclei (MN) is a broadly utilised approach in in vitro toxicity testing. Nevertheless, the specific properties of nanomaterials (NMs) give rise to concerns regarding the optimal methodological variants of the MN ...
Tereza Cervena, Andrea Rossnerova, Tana Zavodna, Jitka Sikorova, Kristyna Vrbova, Alena Milcova, Jan Topinka, Pavel Rossner   +7 more
doaj   +1 more source

Reversibility of cell surface label rearrangement [PDF]

, 1976
Cell surface labeling can cause rearrangements of randomly distributed membrane components. Removal of the label bound to the cell surface allows the membrane components to return to their original random distribution, demonstrating that label is ...
Brown, Susan Smith, Revel, Jean-Paul
core   +1 more source

The Human Fungal Pathogen Cryptococcus neoformans Escapes Macrophages by a Phagosome Emptying Mechanism That Is Inhibited by Arp2/3 Complex-Mediated Actin Polymerisation [PDF]

, 2010
The lysis of infected cells by disease-causing microorganisms is an efficient but risky strategy for disseminated infection, as it exposes the pathogen to the full repertoire of the host's immune system.
A Casadevall, A Drengk, A Pendleton, AE Brouwer, BJ Park, C Charlier, D Liebl, E Groves, H Ma, H Ma, HD Ochs, J Pieters, J Pizarro-Cerda, J Riedl, JL Gaillard, JM Stevens, JP Grabenstein, JR Peterson, K Hybiske, LG Tilney, LR Prost, M Alvarez, M Clarke, M Desjardins, M Hagedorn, M Shi, NE Freitag, NR Jog, PT Yam, R Rohatgi, RC May, RH Insall, Robin C. May, SC Tucker, Simon A. Johnston, Stuart M. Levitz, TA Lyubchenko   +36 more
core   +3 more sources

Quantitative Analysis of the Cytoskeleton’s Role in Inward Rectifier KIR2.1 Forward and Backward Trafficking

Frontiers in Physiology, 2022
Alteration of the inward rectifier current IK1, carried by KIR2.1 channels, affects action potential duration, impacts resting membrane stability and associates with cardiac arrhythmias.
Encan Li, Vera Loen, Willem B. van Ham, Willy Kool, Marcel A. G. van der Heyden, Hiroki Takanari   +5 more
doaj   +1 more source

Occurrence and a possible mechanism of penetration of natural killer cells into k562 target cells during the cytotoxic interaction [PDF]

, 1995
The cytotoxic interaction between cloned human Natural Killer (NK) cells and K562 target cells was studied using confocal laser scanning microscopy (CLSM) and conventional fluorescence microscopy.
de Grooth, B.G., Figdor, Carl, Greve, Jan, Radosevic, K., Radosevic, Katarina, Segers-Nolten, Gezina M.J., van Leeuwen, Anne Marie T.   +6 more
core   +3 more sources

Bioactive Phenylalanine Derivatives and Cytochalasins from the Soft Coral-Derived Fungus, Aspergillus elegans

Marine Drugs, 2013
One new phenylalanine derivative 4′-OMe-asperphenamate (1), along with one known phenylalanine derivative (2) and two new cytochalasins, aspochalasin A1 (3) and cytochalasin Z24 (4), as well as eight known cytochalasin analogues (5–12) were isolated from
Xue-Ping Sun, Guang-Ying Chen, Dong-Lin Zhao, Kai-Ling Wang, Min Chen, Lu-Yong Wu, Chang-Lun Shao, Cai-Juan Zheng, Chang-Yun Wang   +8 more
doaj   +1 more source

Effect of Culture Conditions on Metabolite Production of Xylaria sp.

Molecules, 2015
Seeking a strategy for triggering the cryptic natural product biosynthesis to yield novel compounds in the plant-associated fungus Xylaria sp., the effect of culture conditions on metabolite production was investigated.
Hongqi Zhang, Zhangshuang Deng, Zhiyong Guo, Yan Peng, Nianyu Huang, Haibo He, Xuan Tu, Kun Zou   +7 more
doaj   +1 more source