Results 11 to 20 of about 24,776 (201)

YAP/TAZ regulates the expression of proteoglycan 4 and tenascin C in superficial-zone chondrocytes [PDF]

European Cells & Materials, 2020
The roles of cell division control protein 42 homologue (CDC42) and actin polymerisation in regulating the phenotype of superficial-zone chondrocytes (SZCs) have been demonstrated in vitro; however, the signalling pathway(s) downstream have yet to be ...
E Delve, V Co, SC Regmi, J Parreno, TA Schmidt, RA Kandel   +5 more
doaj   +1 more source

Cytoskeleton-disrupting agent cytochalasin B reduces oxidative stress caused by high glucose in the human arterial smooth muscle

Journal of Pharmacological Sciences, 2020
The role of cytoskeleton dynamics in the oxidative stress toward human vasculature has been unclear. The current study examined whether the cytoskeleton-disrupting agent cytochalasin B reduces oxidative stress caused by high glucose in the human arterial
Kazumi Takaishi, Hiroyuki Kinoshita, Guo-Gang Feng, Toshiharu Azma, Shinji Kawahito, Hiroshi Kitahata   +5 more
doaj   +1 more source

TREK-1 Regulates Cytokine Secretion from Cultured Human Alveolar Epithelial Cells Independently of Cytoskeletal Rearrangements. [PDF]

PLoS ONE, 2015
TREK-1 deficient alveolar epithelial cells (AECs) secrete less IL-6, more MCP-1, and contain less F-actin. Whether these alterations in cytokine secretion and F-actin content are related remains unknown.
Andreas Schwingshackl, Esra Roan, Bin Teng, Christopher M Waters   +3 more
doaj   +1 more source

Cell contractile force measured using a deformable hollow capsule

The EuroBiotech Journal, 2022
There are several possible ways to measure the contraction of cells in vitro. Here, we report measurements of the contractile properties of 3T3-L1 cells grown to confluence on 3D hollow capsules.
Ting Julia Ho Yee, Martin Donald K
doaj   +1 more source

Cyclic mechanical strain with high-tensile triggers autophagy in growth plate chondrocytes

Journal of Orthopaedic Surgery and Research, 2022
Background Mechanical loading has been widely considered to be essential for growth plate to maintain metabolism and development. Cyclic mechanical strain has been demonstrated to induce autophagy, whereas the relationship between cyclic tensile strain ...
Jin-ming Zhang, Zheng-gang Wang, Zhi-yi He, Liang Qin, Jiang Wang, Wen-tao Zhu, Jun Qi   +6 more
doaj   +1 more source

The Modulation of Functional Status of Bovine Spermatozoa by Progesterone

Animals, 2021
The aim of this study is to identify the effects of progesterone (PRG) on the capacitation and the acrosome reaction in bovine spermatozoa. The fresh sperm samples were incubated with and without capacitation inductors (heparin, dibutyryl cyclic ...
Vitaly Denisenko, Irena Chistyakova, Natalia Volkova, Ludmila Volkova, Baylar Iolchiev, Tatyana Kuzmina   +5 more
doaj   +1 more source

Tumor stiffness is unrelated to myosin light chain phosphorylation in cancer cells. [PDF]

PLoS ONE, 2013
Many tumors are stiffer than their surrounding tissue. This increase in stiffness has been attributed, in part, to a Rho-dependent elevation of myosin II light chain phosphorylation.
Hui-Jun Yu, Leonid A Serebryannyy, Madeline Fry, Madelyne Greene, Olga Chernaya, Wen-Yang Hu, Teng-Leong Chew, Nadim Mahmud, Shrihari S Kadkol, Sarah Glover, Gail Prins, Zuzana Strakova, Primal de Lanerolle   +12 more
doaj   +1 more source

The Relationship between fenestrations, sieve plates and rafts in liver sinusoidal endothelial cells. [PDF]

PLoS ONE, 2012
Fenestrations are transcellular pores in endothelial cells that facilitate transfer of substrates between blood and the extravascular compartment. In order to understand the regulation and formation of fenestrations, the relationship between membrane ...
Dmitri Svistounov, Alessandra Warren, Gregory P McNerney, Dylan M Owen, Dusan Zencak, Svetlana N Zykova, Harry Crane, Thomas Huser, Ronald J Quinn, Bård Smedsrød, David G Le Couteur, Victoria C Cogger   +11 more
doaj   +1 more source

Modulation of TMEM16A-Channel Activity as Ca2+ Activated Cl− Conductance via the Interaction With Actin Cytoskeleton in Murine Portal Vein

Journal of Pharmacological Sciences, 2014
.: TMEM16A is a major component of Ca2+-activated Cl− channel (CaCC) conductance in murine portal vein smooth muscle cells (mPVSMCs). Here, the regulation of CaCC activity by the actin cytoskeleton was examined in mPVSMCs.
Junya Ohshiro, Hisao Yamamura, Yoshiaki Suzuki, Yuji Imaizumi   +3 more
doaj   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source