Results 61 to 70 of about 24,776 (201)

Urokinase plasminogen activator inhibits HIV virion release from macrophage-differentiated chronically infected cells via activation of RhoA and PKCε. [PDF]

PLoS ONE, 2011
HIV replication in mononuclear phagocytes is a multi-step process regulated by viral and cellular proteins with the peculiar feature of virion budding and accumulation in intra-cytoplasmic vesicles.
Francesca Graziano, Chiara Elia, Carlo Laudanna, Guido Poli, Massimo Alfano   +4 more
doaj   +1 more source

Evidence for Drop‐Like Nuclear Deformation in Sheared Endothelial Monolayers

Small, EarlyView.
Physiological shear stress smoothens endothelial monolayers by selectively eliminating less‐spread cells with tall, wrinkled nuclei. Nuclear volume and surface area remain constant, consistent with drop‐like deformation governed by geometric constraints.
Mohammad Mohajeri, Ting‐Ching Wang, Pooja Agarwal, Simran Kaur, Ankit Kumar, Richard B. Dickinson, Abhishek Jain, Tanmay P. Lele   +7 more
wiley   +1 more source

Opto-Electric Cellular Biosensor Using Optically Transparent Indium Tin Oxide (ITO) Electrodes

Sensors, 2008
Indium tin oxide (ITO) biosensors are used to perform simultaneous optical and electrical measurements in order to examine the dynamic cellular attachment, spreading, and proliferation of endothelial cells (ECs) as well as cytotoxic effects when exposed ...
Kenneth D. Kihm, Philip D. Rack, Anthony E. English, Seung I. Jun, Chuck H. Margraves, Chang K. Choi   +5 more
doaj  

Molecular basis for a pore block of Tentonin 3 expressed in HEK293 cells by a conopeptide, NMB‐1

British Journal of Pharmacology, EarlyView.
Background and Purpose Tentonin 3 (TTN3/TMEM150C) is a mechanosensitive ion channel that plays critical roles in mechanotransduction processes. TTN3 forms a tetramer with a predicted rectangular shape and a central pore. A conotoxin ρ‐TIA and its synthetic analog, noxious mechanosensation blocker 1 (NMB‐1), were initially developed to inhibit slowly ...
Sujin Lim, Junhyuk Woo, Sungmin Pak, Joonho Paik, Gyu‐Sang Hong, Ji Hun Wi, Sanghee Lee, Cristina Fenollar‐Ferrer, Kyungreem Han, Young Kee Shin, Uhtaek Oh   +10 more
wiley   +1 more source

EFFECT OF COLLAGEN I GEL ON APOPTOSIS OF RAT HEPATIC STELLATE CELLS

Acta Medica, 2013
Activated hepatic stellate cells (HSC) are a major source of fibrous proteins in cirrhotic liver. Inducing or accelerating their apoptosis is a potential way of liver fibrosis treatment.
Lenka Bittnerová, Alena Jiroutová, Emil Rudolf, Martina Řezáčová, Jiří Kanta   +4 more
doaj   +1 more source

Reversal of MPPa‐PDT Resistance in Osteosarcoma by Targeting ROCK2‐Mediated Autophagy

Cell Proliferation, EarlyView.
ROCK2 competes with MST1 to bind to the aa 28‐198 region of SAV1 and then regulates the Hippo pathway to affect autophagy, resulting in the resistance of OS to MPPa‐PDT. Targeted inhibition of ROCK2 by screening for J059‐0149 increases the sensitivity of osteosarcoma to MPPa‐PDT. ABSTRACT Osteosarcoma (OS) is a primary bone tumour that occurs mostly in
Xuan Yi, Xueqiang Deng, Jianyong Deng, Chen Li, Hong Peng, Yunyan Du, Qing Li, Xiaohua Yan, Xin Hu, Yan Zheng, Shenliang Chen, Ting Xiong, Debin Xu, Leifeng Chen, Liang Hao   +14 more
wiley   +1 more source

Mechanical Force Promotes Mitochondrial Transfer From Macrophages to BMSCs to Enhance Bone Formation

Cell Proliferation, EarlyView.
Mechanical tension activates Drp1‐mediated mitochondrial fission in macrophages, facilitating the release of Mito‐EVs that are subsequently transferred to BMSCs. Additionally, the CD200R‐CD200 interaction enhances the uptake of these mechanically stimulated macrophage‐derived Mito‐EVs by BMSCs, ultimately promoting osteogenic differentiation.
Yingyi Li, Ziwei Yan, Yueming Dai, Hanjia Cai, Yue Chen, Yuyi Chen, Ruofan Jin, Wen Sun, Hua Wang   +8 more
wiley   +1 more source

Newly identified properties of known pharmaceuticals and myxobacterial small molecules revealed by screening for autophagy modulators

The FEBS Journal, EarlyView.
Autophagy is a cellular degradation process involved in, for example, immune responses to pathogens and neurodegeneration. To identify modulators of autophagy, we developed a microscopy‐based screening assay and identified previously unknown autophagy‐modulating activities in known drugs and natural products from myxobacteria and fungi.
Janine Fichtner, Yan Yan Beer, H. G. Mauricio Ramm, Sabrina Mühlen, Frank Surup, Jennifer Herrmann, Toni Luise Meister, Stephanie Pfaender, Ursula Bilitewski, Mark Brönstrup, Rolf Müller, Manfred Wirth, Eeva‐Liisa Eskelinen, Ingo Schmitz   +13 more
wiley   +1 more source

Galactomyces ferment filtrate upregulates anchoring junctions and stabilizes actin to maintain the Young's modulus of skin cells in vitro

International Journal of Cosmetic Science, EarlyView.
Ageing causes actin cytoskeleton disorganization, a reduction in cellular components associated with the actin cytoskeleton and focal adhesions, and a reduction in skin firmness. Galactomyces ferment filtrate boosts actin stability, increases expression of anchoring junction proteins, including focal adhesions and protects against loss of firmness ...
Steph Crabtree, Bradley B. Jarrold, Olivia Kent, Matthew C. Ehrman, Timothy J. Hawkins, Viktor Korolchuk, Camila Pereira Braga, John M. Snowball, Makio Tamura, Tomohiro Hakozaki, Akira Matsubara, John E. Oblong, Max Brown   +12 more
wiley   +1 more source

Cytochalasin D Induces Increased Actin Synthesis in HEp-2 Cells [PDF]

, 1983
Janet Tannenbaum, Gabriel C. Godman
openalex   +3 more sources