Results 71 to 80 of about 24,776 (201)

Mycobacterium avium Subsp. paratuberculosis and Human Endogenous Retrovirus in Italian Patients With Inflammatory Bowel Disease (IBD) and Irritable Bowel Syndrome (IBS)

Immunology, EarlyView.
Inflammatory bowel disease (IBD), comprising ulcerative colitis (UC) and Crohn's disease (CD), is a recognised gastrointestinal disorder. Mycobacterium avium subspecies paratuberculosis (MAP) is implicated in IBD pathogenesis. Persistent exposure and active infections by MAP may contribute to the unsilencing of human endogenous retroviruses (HERV ...
Stefano Ruberto, Alfredo Santovito, Gian P. Caviglia, Marta Noli, Davide Cossu, Davide G. Ribaldone, Demis Pitoni, Simona Frara, Elisa Tribocco, Chiara Rosso, Marta Guriglia, Ilaria Cossu, Pier A. Tovo, Massimiliano Bergallo, Leonardo A. Sechi   +14 more
wiley   +1 more source

Traction force generation in Plasmodium sporozoites is modulated by a surface adhesin

Journal of Microscopy, EarlyView.
Abstract Plasmodium sporozoites are the highly polarised and motile forms of the malaria parasite transmitted by mosquitoes to the vertebrate hosts. Sporozoites use myosin motors to generate retrograde flow of actin filaments. These are linked to plasma membrane spanning adhesins, which in turn bind to the extracellular environment, resulting in ...
Johanna Ripp, Dimitri Probst, Mirko Singer, Ulrich S. Schwarz, Friedrich Frischknecht   +4 more
wiley   +1 more source

Microcondensate‐Mediated Intracellular Infusion of mRNA Across the Plasma Membrane

Angewandte Chemie, Volume 138, Issue 1, 2 January 2026.
The delivery of mRNA without lipid nanoparticles remains challenging. FcB(L17E)3‐driven microcondensates with nucleic acids, aided by short ssDNA, enable coacervate formation, actin‐dependent cytosolic infusion, and in vivo protein expression, offering a potential platform for next‐generation mRNA therapeutics and vaccination.
Yoshimasa Kawaguchi, Ayumi Kikkawa, Seigo Kimura, Hiroshi Abe, Shiroh Futaki   +4 more
wiley   +2 more sources

Bioactive Steroids with Methyl Ester Group in the Side Chain from a Reef Soft Coral Sinularia brassica Cultured in a Tank

Marine Drugs, 2017
A continuing chemical investigation of the ethyl acetate (EtOAc) extract of a reef soft coral Sinularia brassica, which was cultured in a tank, afforded four new steroids with methyl ester groups, sinubrasones A–D (1–4) for the first time. In particular,
Chiung-Yao Huang, Jui-Hsin Su, Chih-Chuang Liaw, Ping-Jyun Sung, Pei-Lun Chiang, Tsong-Long Hwang, Chang-Feng Dai, Jyh-Horng Sheu   +7 more
doaj   +1 more source

Deciphering the biosynthetic pathways of lichen acids

New Phytologist, EarlyView.
Summary Depsides and depsidones are polyketide‐derived lichen acids widely distributed in lichen thalli, yet the biosynthetic gene clusters (BGCs) responsible for their production remain poorly understood. To address this gap, we investigated the diversity and evolutionary relationships of polyketide BGCs in lichens.
Wonyong Kim, Tânia Keiko Shishido, Huong T. Pham, Kyo Bin Kang, Rundong Liu, Matti Wahlsten, Jérôme Collemare, Hyun Park, Soon‐Ok Oh, Hyung‐Ho Ha, Hangun Kim, Jae‐Seoun Hur   +11 more
wiley   +1 more source

Citocalasinas produzidas por Xylaria sp., um fungo endofítico de Piper aduncum (piperaceae) Cytochalasins produced by Xylaria sp., an endophytic fungus from Piper aduncum

Química Nova, 2010
A chemical study on the EtOAc extract produced by Xylaria sp., an endophytic fungus from Piper aduncum, resulted in the isolation of a new cytochalasin 1, along with five known 19,20-epoxycytochalasin D (2), C (3), N (4), Q (5), and R (6).
Geraldo H. Silva, Camila M. de Oliveira, Helder L. Teles, Vanderlan da S. Bolzani, Angela R. Araujo, Ludwig H. Pfenning, Maria Claudia M. Young, Claudio M. Costa-Neto, Renato Haddad, Marcos N. Eberlin   +9 more
doaj   +1 more source

Cytochalasin D restores nuclear size acting on F-actin and IZUMO1 localization in low-quality spermatozoa. [PDF]

Int J Biol Sci, 2023
Martinez G, Cappetta D, Telesca M, Urbanek K, Castaldo G, Dhellemmes M, Mele VG, Chioccarelli T, Porreca V, Barbotin AL, Boursier A, Guillou F, Coutton C, Brouillet S, De Angelis A, Berrino L, Pierantoni R, Cobellis G, Chianese R, Manfrevola F.   +19 more
europepmc   +1 more source

The Outcome of Intracellular Selenomonas sputigena and its Impact on Gingival Keratinocytes

Molecular Oral Microbiology, EarlyView.
ABSTRACT Selenomonas sputigena is an understudied oral pathobiont associated with periodontitis and dental caries. We recently demonstrated that S. sputigena binds to gingival epithelial cells (GECs), where afterwards the bacterium causes robust in vitro pro‐inflammatory cytokine production and migration of monocytes and neutrophils.
Colin G. Hawkes, Travis J. Chiarelli, Doaa N. Abdallah, Grayson Way, Huiping Zhou, Jason A. Carlyon, Daniel P. Miller   +6 more
wiley   +1 more source

Mechanical stretch-induced vascular hypertrophy occurs through modulation of leptin synthesis-mediated ROS formation and GATA-4 nuclear translocation

Frontiers in Pharmacology, 2015
Background: Obesity and hypertension are associated with increased leptin production contributing to cardiovascular remodeling. Mechanisms involving mechanical stretch-induced leptin production and the cross talk between signaling pathways leading to ...
Crystal M Ghantous, Firas H Kobeissy, Nadia eSoudani, Farah eAbdel Rahman, Moustafa eAl Hariri, Hana A Itani, Ramzi eSabra, Asad eZeidan   +7 more
doaj   +1 more source

Engineering a 3D In Vitro Model of Human Gingival Tissue Equivalent with Genipin/Cytochalasin D. [PDF]

Int J Mol Sci, 2022
Koskinen Holm C, Qu C.
europepmc   +1 more source