Results 81 to 90 of about 19,108 (270)

Mitochondria and the Actin Cytoskeleton in Neurodegeneration

Cytoskeleton, EarlyView.
ABSTRACT Mitochondrial dysfunction and cytoskeletal disorganization are widely recognized hallmarks of neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS).
Shivani Tuli, Preet Patel, Aneri Shethji, David Gau   +3 more
wiley   +1 more source

Rutaceae Zanthoxylum–Derived 7‐Demethylsuberosin Alleviates the Rheumatoid Arthritis Through Inhibiting the Maturation of Dendritic Cells via Targeting MAPK14 Functional Food‐Based 7‐Demethylsuberosin

Food Frontiers, EarlyView.
This study revealed that 7‐demethylsuberosin exhibits immunosuppressive effects both in vivo and in vitro. Furthermore, it inhibits the phosphorylation of MAPK14 by targeting it, thereby modulating dendritic cell (DC) maturation and function and reducing inflammation across various in vivo models.
Peng Han, Bo Wang, Luyang Han, Yanbo Zhu, Jiawei Dong, Yuekang Xu, Xiaoying Liu, Jinyao Li   +7 more
wiley   +1 more source

Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism [PDF]

, 2015
Inflammasomes are cytosolic caspase-1-activation complexes that sense intrinsic and extrinsic danger signals, and trigger inflammatory responses and pyroptotic cell death. Homotypic interactions among Pyrin domains and caspase recruitment domains (CARDs)
A Dorfleutner, A Druilhe, A Lu, A Lu, A Vezzani, Alexander B Tong, Alvin Lu, B Wu, C Stehlik, CP Guimaraes, E de Alba, E Latz, EF Pettersen, EH Egelman, EM Kofoed, EW Humke, F Bedoya, F DiMaio, F Hou, F Martinon, Florian I Schmidt, G López-Castejón, GG Brusselle, GR Robbins, H Hirakawa, H Wu, Hao Wu, HH Park, Hidde L Ploegh, HT Le, JA Cooper, JA Mindell, JE Caldwell, JP da Cunha, K Kersse, KL Meerbrey, KL Tsao, L Holm, L Zhang, M Aguilera, M Biasini, M Lamkanfi, M Lamkanfi, MD Winn, MF Carlier, N Esser, NA Maun, P Emsley, PD Adams, PM Ridker, Q Qiao, Qian Yin, R Ferrao, SC Lin, SH Lee, SH Scheres, Shuobing Chen, T Wakatsuki, Tian-Min Fu, TR Shaikh, X Cai, Y Qu, Yang Li, YH Lin, Youdong Mao, Z Hu   +65 more
core   +5 more sources

Antifungal activity of extracts from Atacama Desert fungi againstParacoccidioides brasiliensis and identification ofAspergillus felis as a promising source of natural bioactive compounds

Memorias do Instituto Oswaldo Cruz, 2016
Fungi of the genus Paracoccidioides are responsible for paracoccidioidomycosis. The occurrence of drug toxicity and relapse in this disease justify the development of new antifungal agents.
Graziele Mendes, Vívian N Gonçalves, Elaine M Souza-Fagundes, Markus Kohlhoff, Carlos A Rosa, Carlos L Zani, Betania B Cota, Luiz H Rosa, Susana Johann   +8 more
doaj   +1 more source

Secretion of soluble-form CD93 from human endothelial progenitor cells [PDF]

, 2015
ヒト血管内皮前駆細胞(Human endothelial progenitor cells :HEPCs)から分泌される可溶性CD93(sCD93)分子の動態を自主開発した抗ヒトCD93 抗体(mNI-11)を用いて解析した。HEPCs は低濃度であるが、sCD93 分子を培養液中に自然分泌していることがわかった。HEPCs をPKC 活性剤であるPMAで処理したところ、sCD93 分子の分泌は有意に増強した(P < 0.01)。また、PMA 処理の初期段階からsCD93 分泌の増強は認められた。次に ...
Eiji OHNO, Koutarou DOI, Nobunao IKEWAKI, Tohru SONODA, イケワキ ノブナオ, オオノ エイジ, ソノダ トオル, ドイ コウタロウ, 園田 徹, 土井 宏太郎, 大野 英治, 池脇 信直   +11 more
core  

Nucleotide-, chemotactic peptide- and phorbol ester-induced exocytosis in HL-60 leukemic cells [PDF]

, 1990
Undifferentiated and differentiated HL-60 leukemic cells possess nucleotide receptors which functionally couple to phospholipase C via pertussis toxin-sensitive guanine nucleotide-binding proteins (G-proteins).
Seifert, Roland, Wenzel-Seifert, Katharina   +1 more
core   +1 more source

Evidence for Drop‐Like Nuclear Deformation in Sheared Endothelial Monolayers

Small, EarlyView.
Physiological shear stress smoothens endothelial monolayers by selectively eliminating less‐spread cells with tall, wrinkled nuclei. Nuclear volume and surface area remain constant, consistent with drop‐like deformation governed by geometric constraints.
Mohammad Mohajeri, Ting‐Ching Wang, Pooja Agarwal, Simran Kaur, Ankit Kumar, Richard B. Dickinson, Abhishek Jain, Tanmay P. Lele   +7 more
wiley   +1 more source

Preparation, In Vivo Administration, Dose-Limiting Toxicities, and Antineoplastic Activity of Cytochalasin B

Translational Oncology, 2015
An effective and inexpensive protocol for producing cytochalasins A and B is being disclosed to propose a viable method by which to examine the in vivo antineoplastic activity of these congeners in preclinical tumor-bearing mammalian models. In addition,
Matthew Trendowski, Joseph N. Zoino, Timothy D. Christen, Christopher Acquafondata, Thomas P. Fondy   +4 more
doaj   +1 more source

Actin polymerization as a key innate immune effector mechanism to control Salmonella infection. [PDF]

, 2014
Salmonellosis is one of the leading causes of food poisoning worldwide. Controlling bacterial burden is essential to surviving infection. Nucleotide-binding oligomerization domain-like receptors (NLRs), such as NLRC4, induce inflammasome effector ...
Achouri, Sarra, Bryant, Clare E, Cammarota, Eugenia, Cicuta, Pietro, Ekpenyong, Andrew, Guck, Jochen R, Hughes, Katherine, Man, Si Ming, Ng, Gilbert, Rizzo, Alessandro, Tourlomousis, Panagiotis, Wright, John A   +11 more
core   +1 more source

Untreated Hair Dye Effluents Enter the Environment: Are They a Threat to Human Health?

Environmental Toxicology, EarlyView.
ABSTRACT The effluents generated during the process of hair dyeing exhibit a complex composition, comprising chemical compounds with varying toxicity levels. While the adverse impact of hair dyes on human health is acknowledged, there is a notable absence of studies addressing the toxicity associated with effluents produced during these activities. The
Letícia Cristina Gonçalves, Matheus Mantuanelli Roberto, Adriana Fabiana Corrêa da Silva, Maria Aparecida Marin‐Morales   +3 more
wiley   +1 more source