Results 51 to 60 of about 630,553 (340)

Identifying prognostic targets in metastatic prostate cancer beyond AR

FEBS Open Bio, EarlyView.
Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng, Eric Feng, Tracy Berg, Isabella S. Nguyen, Lilac G. Nguyen, William Chen, Meng Zhang, David Quigley, Marina Sharifi, Haolong Li, Ilsa Coleman, Peter S. Nelson, Martin Sjöström, Shuang G. Zhao   +13 more
wiley   +1 more source

PERFIL DE SENSIBILIDAD DE HEP-G2 COMO MODELO PARA EVALUACIÓN DE ACTIVIDAD CITOTÓXICA DE XENOBIÓTICOS BIOACTIVADOS VIA CYP450 SENSITIVILITY PROFILE HEP-G2 AS A MODEL OF CYTOTOXIC ACTIVITY DETERMINATION OF BIOACTIVATED XENOBIOTICS VIA CYP450

Vitae, 2009
Para establecer la acción anticancerígena se han propuesto numerosas metodologías, principalmente enfocadas en la valoración de la citotoxicidad in vitro sobre líneas celulares neoplásicas derivadas de diferentes tipos de cáncer humano; sin embargo, gran
Stephanie O PRIETO, Fabio A ARISTIZÁBAL G   +1 more
doaj  

How are ‘atypical’ sulfite dehydrogenases linked to cell metabolism? – Interactions between the SorT sulfite deydrogenase and small redox proteins

Frontiers in Microbiology, 2011
Sulfite dehydrogenases are enzymes that catalyze the oxidation of the toxic and mutagenic compound sulfite to sulfate, thereby protecting cells from adverse effects associated with sulfite exposure.
Louie eLow, James Ryan Kilmartin, Paul V Bernhardt, Ulrike eKappler   +3 more
doaj   +1 more source

Earthing effects on mitochondrial function: ATP production and ROS generation

FEBS Open Bio, EarlyView.
In contrast to sham and naive controls, grounded mitochondria not only exhibit significantly enhanced energy production but also demonstrate a remarkable reduction in membrane potential and oxidative stress. This suggests a profound improvement in mitochondrial health, presenting a promising avenue for therapeutic interventions.
Cecilia Giulivi, Richard Kotz
wiley   +1 more source

An efficient strategy for producing RNA‐free Nucleocapsid protein of SARS‐CoV‐2 for biochemical and structural investigations

FEBS Open Bio, EarlyView.
Cleavable N‐terminal Thioredoxin fusion enabled soluble expression and purification of otherwise insoluble SARS‐CoV‐2 Nucleocapsid (N) protein. A four‐step purification strategy yielded highly homogeneous, RNA‐free N protein. Binding assays showed high RNA affinity (Kd ~ 28 nm). The study will facilitate high‐resolution structural studies of N protein,
Shweta Singh, Gagan D. Gupta
wiley   +1 more source

Phylogenetic and functional analysis of cyanobacterial Cytochrome c6-like proteins

Frontiers in Plant Science, 2023
All known photosynthetic cyanobacteria carry a cytochrome c6 protein that acts transferring electrons from cytochrome b6f complex to photosystem I, in photosynthesis, or cytochrome c oxidase, in respiration.
Alejandro Torrado, Macarena Iniesta-Pallarés, Adrián Velázquez-Campoy, Adrián Velázquez-Campoy, Adrián Velázquez-Campoy, Adrián Velázquez-Campoy, Consolación Álvarez, Vicente Mariscal, Fernando P. Molina-Heredia   +8 more
doaj   +1 more source

Interaction of class III cellobiose dehydrogenase with lytic polysaccharide monooxygenase

FEBS Open Bio, EarlyView.
The activity of lytic polysaccharide monooxygenase (LPMO) is supported by its auxiliary enzyme cellobiose dehydrogenase (CDH). The catalytic activity of both enzymes is coupled by electron transfer and a cyclic cascade generating substrates for both enzymes – hydrogen peroxide for LPMO and oxidized and non‐oxidized cellobiose and cello‐oligosaccharide ...
Angela Giorgianni, Florian Csarman, Peicheng Sun, Mirjam Kabel, Roland Ludwig   +4 more
wiley   +1 more source

Co‐overexpression of the caloric restriction‐induced mitochondrial factors PGC‐1α and MIPEP upregulates Phospho1 expression in adipocytes

FEBS Open Bio, EarlyView.
Caloric restriction that extends lifespan induces the expression of PGC‐1α and MIPEP in white adipose tissue. In this study, co‐overexpression of Pgc‐1α and Mipep upregulated the gene expression of PHOSPHO1. These findings provide new insights into mitochondria‐related mechanisms underlying the effects of caloric restriction in adipocytes.
Mamiko Ishimatsu, Kanari Taki, Asuka Hayami, Komachi Kato, Yuka Nozaki, Yuhei Mizunoe, Takumi Narita, Ryoichi Mori, Yoshikazu Higami, Masaki Kobayashi   +9 more
wiley   +1 more source

Lack of salidroside impact on selected cytochromes encoding genes transcription in the liver of ethanol induced rats

Herba Polonica, 2021
Introduction: The molecular basis of in vivo metabolism of selected representatives of phenylethanoids in the presence of ethanol has not been fully elucidated.
Kujawski Radosław, Szulc Michał, Toboła Maria, Graczyk Marcin, Czora-Poczwardowska Kamila, Baraniak Justyna, Kania-Dobrowolska Małgorzata, Słyńko-Krzyżostaniak Julia, Krajewska-Patan Anna, Mikołajczak Przemysław Ł.   +9 more
doaj   +1 more source

Cytochrome c as a Potentially Clinical Useful Marker of Mitochondrial and Cellular Damage

Frontiers in Immunology, 2016
Mitochondria are evolutionary endosymbionts derived from bacteria. Thus, they bear molecules, such as mitochondrial DNA (mtDNA) that contains CpG DNA repeats and N-formyl peptides (FPs), found in bacteria. Upon cell necrosis or apoptosis, these molecules
T. Eleftheriadis, G. Pissas, V. Liakopoulos, I. Stefanidis   +3 more
semanticscholar   +1 more source