Mutant CHCHD10 disrupts cytochrome c oxidation and activates mitochondrial retrograde signaling. [PDF]
Campos-Ribeiro MA +13 more
europepmc +1 more source
Objective Cerebral ischemic stroke causes neuronal oxygen/energy deprivation, disrupting mitochondrial function including reduced membrane potential and bioenergetics, exacerbating neuronal injury. Mitochondrial defects are, therefore, a central neuropathological node and potential therapeutic target.
Ning Bian +9 more
wiley +1 more source
The role and application potential of cytochrome c in breast cancer therapy. [PDF]
Yue H, Fu Y, Fan X, Zhou F, Liu S.
europepmc +1 more source
Polyphenol‐Based Biomaterials Against Cancer Radio/Chemotherapy‐Induced Intestinal Toxicity
Radiotherapy/chemotherapy often causes intestinal toxicity, impairing cancer patients’ quality of life and treatment efficacy. Polyphenols protect against this injury via multiple mechanisms, but face oral use limitations. This review outlines their protective mechanisms and delivery challenges, highlighting recent oral delivery advances and future ...
Jixu Lu +4 more
wiley +1 more source
The tumor suppressor LACTB remodels mitochondria to promote cytochrome c release and apoptosis. [PDF]
Kamerkar SC +4 more
europepmc +1 more source
Proton-linked effects on the axial coordination in ferric and ferrous horse heart cytochrome c. [PDF]
Sebastiani F +8 more
europepmc +1 more source
Proton-Coupled Electron Transfer in Cytochrome c Oxidase: Heme a Controls the Protonation Dynamics of E286. [PDF]
Baserga F +5 more
europepmc +1 more source
Genome‐Guided Discovery of Antimalarial 4‐Amino‐2,4‐Pentadienoate‐Containing Cyclolipodepsipeptides
Halogenated and glycosylated 4‐amino‐2,4‐pentadienoate‐containing cyclolipodepsipeptides (APD‐CLDs) exhibit potent antiplasmodial activity (IC50 = 25–161 nM) against drug‐sensitive and resistant Plasmodium falciparum strains. ABSTRACT 4‐Amino‐2,4‐pentadienoate‐containing cyclolipodepsipeptides (APD‐CLDs) represent a structurally distinctive family of ...
Hartono Candra +10 more
wiley +1 more source
SLC25A39 identified as a key regulator of hepatocellular carcinoma progression through the mitochondrial ROS-cytochrome c-caspase signaling axis. [PDF]
Yuan M +7 more
europepmc +1 more source

