Results 131 to 140 of about 604,858 (259)

Deficiency of DEK proto‐oncogene alleviates allergic rhinitis by inhibiting RhoA/Ezrin‐mediated mitochondrial fission

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Schematic diagram of the mechanism of DEK regulating RhoA activation Ezrin. Upon house dust mite (HDM) stimulation, HDM‐specific immunoglobulin E (IgE) and inflammatory factors such as interleukin 4 (IL‐4), IL‐5, IL‐13, and eosinophils increased in the nasal mucosa.
Longzhu Dai   +8 more
wiley   +1 more source

Targeting signaling pathways in neurodegenerative diseases: Quercetin's cellular and molecular mechanisms for neuroprotection

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Quercetin regulates signaling pathways in neurodegenerative diseases, including NF‐κB, sirtuins, and PI3K/Akt. Studies show quercetin improves symptoms and pathology in neurodegenerative models. The study aims to incorporate laboratory research into practical medical treatment, focusing on quercetin's neuroprotective effects and optimal dosage ...
Md. Rezaul Islam   +13 more
wiley   +1 more source

Bio‐Inspired Self‐Assembly of Enzyme‐Micelle Systems for Semi‐Artificial Photosynthesis

open access: yesAngewandte Chemie, EarlyView.
This study introduces a bio‐hybrid assembly inspired by lipid‐protein interactions in nature by utilizing photosensitized surfactants that self‐assemble into light‐absorbing micellar scaffolds capable of interfacing with hydrogenases and formate dehydrogenases. This semi‐artificial approach enabled benchmark turnover numbers for solar H2 production and
Yongpeng Liu   +14 more
wiley   +2 more sources

A digital instrument simulator to optimize the development of hyperspectral systems: application for intraoperative functional brain mapping [PDF]

open access: yesarXiv
Intraoperative optical imaging is a localization technique for the functional areas of the human brain cortex during neurosurgical procedures. These areas can be assessed by monitoring cerebral hemodynamics and metabolism. A robust quantification of these biomarkers is complicated to perform during neurosurgery due to the critical context of the ...
arxiv  

Preparation of Cytochrome c with the Aid of Paper Electrophoresis. [PDF]

open access: bronze, 1952
Sven Paléus   +5 more
openalex   +1 more source

Identifying the optimal dose of cannabidiol by intrabuccal administration in Kramnik (C3HeB/FeJ) mice

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Cannabidiol (CBD) has numerous therapeutic properties, and is used to treat neurological conditions, such as neuroinflammation. However, the optimal dose of CBD to penetrate the brain requires further investigation. The primary aim of this study was to use a mouse model and the intrabuccal route for CBD administration to determine the optimal dose at ...
Oluwadara Pelumi Omotayo   +4 more
wiley   +1 more source

How germline genes promote malignancy in cancer cells

open access: yesBioEssays, Volume 45, Issue 1, January 2023., 2023
We hypothesize that activation of a “germline program” promotes oncogenesis. Expression of otherwise germline specific genes may result in pseudomeiotic activity, thereby promoting oncogenesis through genomic instability. Other processes that are differentially regulated in the germline, such as migration and epigenetic – and metabolic plasticity, may ...
Jan Willem Bruggeman   +4 more
wiley   +1 more source

Identifying Key Properties That Drive Redox Mediator Activity in Lactiplantibacillus Plantarum

open access: yesAngewandte Chemie, EarlyView.
Synthesis and isolation of structurally diverse quinones led to defining key physicochemical properties and biochemical interactions that drive type‐II NADH dehydrogenase (Ndh2)‐dependent extracellular electron transfer activity in Lactiplantibacillus plantarum.
Benjamin T. Blackburn   +7 more
wiley   +2 more sources

Demonstration of cytochrome reductases in rat liver peroxisomes: biochemical and immunochemical analyses.

open access: yesJournal of Lipid Research, 1988
In this study we utilized the analytical cell fractionation approach in combination with immunoblotting techniques and immunoelectron microscopy to test for the presence of NADPH cytochrome P-450 reductase and NADH cytochrome c (b5) reductase in rat ...
C Gutierrez, R Okita, S Krisans
doaj  

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