Results 131 to 140 of about 2,499,952 (347)

Effect of Ticagrelor Versus Clopidogrel After Off‐Pump Coronary Artery Bypass Grafting on Postoperative Atrial Fibrillation: A Cohort Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background This study aimed to explore the effect of a P2Y12 inhibitor regimen on the occurrence of postoperative atrial fibrillation (POAF) after off‐pump coronary artery bypass graft surgery in carriers with the cytochrome P450 family 2 subfamily C ...
Qin Jiang, Keli Huang, Lixue Yin, Hong Kong, Zhenglin Yang, Shengshou Hu   +5 more
doaj   +1 more source

Precision Diagnostics in Sports‐Related Traumatic Brain Injury: Pathophysiology, Biomarker Development and Emerging Technologies

Advanced Sensor Research, EarlyView.
Sports‐related traumatic brain injuries (TBIs) remain underdiagnosed, within amateur athletic cohorts. This review critically synthesises recent advancements in AI‐assisted neuroimaging, blood‐based biomarker profiling, wearable biosensing platforms for early detection, injury stratification, and longitudinal surveillance of TBIs.
Daniel Nicol, Mohamed T. Patel, Debarati Bhowmik, Pola Goldberg Oppenheimer   +3 more
wiley   +1 more source

Chemical Approaches for Array Based Detection of Amyloids

Advanced Sensor Research, EarlyView.
Amyloids are protein aggregates with both pathological and functional roles. Their detection is challenged by structural polymorphism, isoform diversity, and dynamic aggregation behavior. This review presents chemical array‐based sensing strategies that address these complexities, emphasizing fluorescence and colorimetric methods, alongside ...
Paulo M. Simon, Yijia Xu, Amandeep Kaur
wiley   +1 more source

Sulfite: Cytochrome \u3cem\u3ec\u3c/em\u3e Oxidoreductase from \u3cem\u3eThiobacillus novellus\u3c/em\u3e [PDF]

, 2000
Direct oxidation of sulfite to sulfate occurs in various photo- and chemotrophic sulfur oxidizing microorganisms as the final step in the oxidation of reduced sulfur compounds and is catalyzed by sulfite:cytochrome c oxidoreductase (EC1.8.2.1).
Bennett, Brian, Dahl, Christiane, Deutzmann, Rainer, Kappler, Ulrike, McEwan, Alistair G., Rethmeier, Jörg, Schwarz, Günter   +6 more
core   +1 more source

Bio‐Inspired Polymer Nanoreactor: Integrating Hemin Coordination and Micellar Confinement for Catalysis in Water

Advanced Sustainable Systems, EarlyView.
This study develops an amphiphilic copolymer nanocarrier (P(His‐r‐Sty)‐b‐PDMAA) for aqueous hemin catalysis, enabling efficient styrene cyclopropanation (94.4% yield, 0.3 mol% hemin) with excellent recyclability (>90% activity after 4 cycles), overcoming solubility and microenvironment challenges.
Lulu Chen, Xiankun Wu, Vasco Figueiredo Batista, Mathias Dimde, Changzhu Wu   +4 more
wiley   +1 more source

Branched‐Chain α Keto‐Acid Dehydrogenase Kinase‐Mediated AKT Phosphorylation Promotes RCC Tumorigenesis and Drug Resistance

Advanced Science, EarlyView.
This study identifies a novel oncogenic role and a previously unrecognized phosphorylation substrate of BCKDK in RCC, wherein it promotes tumor progression and drug resistance through AKT phosphorylation at both Thr308 and Ser473 sites and activation of AKT/mTOR and AKT/ABCB1 signaling pathways, offering a promising prognostic marker and therapeutic ...
Qin Tian, Jinxiang Wang, Qiji Li, Yangruiyu Liu, Yanping Chen, Jiacheng Feng, Zi‐Ning Lei, Harsh Patel, Chao‐Yun Cai, Yuzhi Xu, Chuntao Quan, Lingyan Fei, Zexiu Xiao, Shuo Fang, Tianxin Lin, Zhe‐Sheng Chen, Yuchen Liu, Leli Zeng, Yihang Pan   +18 more
wiley   +1 more source

Role of SLC16A10 in Psoriasis Through the Regulation of Arachidonic Acid Metabolism in Keratinocytes

Advanced Science, EarlyView.
This study demonstrates that SLC16A10 plays a crucial role in psoriasis pathogenesis through arachidonic acid metabolism regulation in keratinocytes. Using multi‐omics analysis and experimental validation, researchers identify SLC16A10 as both a diagnostic biomarker and therapeutic target.
Jingyuan Yang, Yixuan Chen, Bowei Li, Shuang Wu, Hang Liang, Xingyue Yang, Xiaozhen Li, Ping Sun, Guangjin Guo, Ting Li, Yuying Jia, Haijiao Li, Mengqi Bai, Jie Xu, Zhijie Liu, Wei Liu, Xiangkang Jiang, Hong Cai   +17 more
wiley   +1 more source

Integrative Omics Reveals Glutamine Catabolism‐Driven Apoptotic Suppression in Monocytes upon Mechanical Unloading

Advanced Science, EarlyView.
This research integrated multi‐omics analysis of bone tissue from HLU and control mice revealed that mechanical unloading suppresses intrinsic apoptosis and augments glutamine (Gln) catabolism in osteoclast lineage cells. The findings highlight pivotal roles for SLC1A5‐mediated Gln metabolism and XIAP/Diablo axis‐mediated apoptosis suppression.
Yi Ding, Fan Tong, Mingqiu Liu, Pin Yang, Jing Zeng, Yinghua Wei, Chunlin Li, Dong Li, Cheng Chang, Yangjun Zhang, Shaoqiong Yi, Fan Hu, Wenjie Shu, Lingqiang Zhang, Chun‐Ping Cui   +14 more
wiley   +1 more source

Analysis of mitochondrial-targeted antioxidant SkQ1 effectiveness on myocardial ischemia-reperfusion injury in a rat model: Focus on morphological and ultrastructural tissue study

Фармация и фармакология (Пятигорск)
Mitochondrial-targeted antioxidant SkQ1 demonstrates a high efficiency in animal models and potentially can be used for minimizing postoperative complications in an on-pump open-heart surgery.The aim of study was to the assessment of preservation degree ...
E. A. Senokosova, E. A. Velikanova, R. A. Mukhamadiyarov, O. D. Sidorova, E. O. Krivkina, L. V. Antonova, E. V. Grigoriev   +6 more
doaj   +1 more source

Melatonin Modulates Glucose Metabolism Reprogramming via Targeting G6PD to Alleviate Lead‐Induced Hepatocytes Pyroptosis in Common Carp (Cyprinus carpio L.)

Advanced Science, EarlyView.
This study reveals that Lead reprograms glucose metabolism to enhance H3K18la, driving DRP1‐dependent mitochondrial DNA leakage and cGAS‐STING‐mediated pyroptosis. Melatonin targets G6PD to suppress glycolysis‐driven H3K18la and restore mitochondrial homeostasis, thereby alleviating Lead‐induced liver injury in common carp through disruption of the ...
Zhiying Miao, Xiaofeng Ji, Lai Wei, Zhiruo Miao, Shiwen Xu   +4 more
wiley   +1 more source