Results 161 to 170 of about 28,229,161 (299)

Targeting Mitochondrial Redox Signaling Promotes Neuroregeneration and Functional Recovery in a Multiple Sclerosis Model

Advanced Science, EarlyView.
Modulation of mitochondrial redox signaling by furapyrrodole activates CYB5R3 and suppresses Notch signaling, unlocking the regenerative potential of endogenous neural progenitor cells. This approach promotes neurogenesis, oligodendrogenesis, and remyelination, thereby improving neuronal function in a mouse model of multiple sclerosis and identifying ...
Yuki Narushima, Joshua Saylor, Shun Saito, Jinyan Zhou, Haruka Kawano, Shehata Anwar, Haruki Oba, Rachel Huezo, Miyu Okano, Haruki Matsuda, Makoto Kawatani, Kaori Honda, Hiroyuki Osada, Yuta Kikuchi, Masahito Ohue, Masami Ishibashi, Takayoshi Arai, Makoto Inoue, Midori A. Arai   +18 more
wiley   +1 more source

Intermolecular Carbon–Carbon Naphthalene Coupling Involves a Radical Mechanism Driven by Cytochrome P450 in Alternaria alternata

Angewandte Chemie, EarlyView.
1,8‐DHN is an important intermediate to form complex aromatic ring systems. Phenol‐coupling reactions are important for the dimerization of two molecules. Here, we show that a fungal cytochrome P450 enzyme catalyzes specific C─C bonds. ABSTRACT Dihydroxynaphthalene (DHN) derivatives are precursors of biologically important molecules, including melanin ...
Jia Gao, Leyao Chen, Karin Steffen, Henrik Schweder, Birgit Schreckenberger, Shu‐Ming Li, Ben Auxier, Antonis Rokas, Reinhard Fischer   +8 more
wiley   +2 more sources

Chelidonic acid attenuates 7,12-dimethylbenz[a]anthracene-induced oral carcinogenesis by modulating oxidative stress and detoxification pathways in Golden Syrian hamsters. [PDF]

J Oral Biol Craniofac Res
Krishnan H, Sivasankaran SM, Balasubramaniyan V, Radhakrishnan MN, Manoharan S.   +4 more
europepmc   +1 more source

Living Electronics: Microbial Metabolism as Batteries, Resistors, and Capacitors

Advanced Electronic Materials, EarlyView.
Three microorganisms are assigned the three elementary roles of a circuit on one sheet of paper. Dormant Bacillus subtilis spores germinate to switch the power source on; a photosynthetic Synechocystis biofilm sets resistance by the color and intensity of light; and a respiring Shewanella oneidensis biofilm stores charge. Together they form a printable
Botian Wang, Ruohan Zhang, Seokheun Choi
wiley   +1 more source

A 3D Multitask Graph Neural Network Framework for Ames Mutagenicity Prediction

Advanced Intelligent Discovery, EarlyView.
Our proposed multitask graph neural network model has a high predictive accuracy for Ames mutagenicity. By operating directly on molecular graph representations instead of traditional molecular descriptors, and predicting strain‐specific results, the model outperforms most existing benchmarks.
Abigail E. Teitgen, Eugenia Ulzurrun, Nuria E. Campillo, Eduardo R. Hernández   +3 more
wiley   +1 more source

Photoactivated Platinum Complexes: Targeting Membrane Proteins and Organelles for Precision Cancer Therapy

Angewandte Chemie, EarlyView.
This review highlights an emerging anticancer approach integrating platinum agents into photodynamic therapy (PDT) and photoactivated chemotherapy (PACT) systems, further augmented by cancer cell membrane‐ and organelle‐targeting. By directing photoactivated platinum complexes from nontargeted distribution to cancer cells or defined subcellular sites ...
Shu Chen, Qiyuan Zhou, Jiaqian Xu, Guangyu Zhu   +3 more
wiley   +2 more sources

Patient‐Derived Fibroblasts as a Clinically Relevant Model of Kearns–Sayre Syndrome

Annals of Neurology, EarlyView.
Objective Kearns–Sayre syndrome (KSS) is characterized by single large‐scale mitochondrial DNA deletions and by severe early‐onset clinical manifestations with neurological involvement. Reliable disease models, as well as validated biomarkers or effective treatments, are lacking.
Laura Valls‐Roca, Adrià Vilaseca‐Capel, Judith Cantó‐Santos, Ester Tobías, Félix Andújar‐Sánchez, Laia Farré‐Tarrats, Frederic Tort, Carles Rentero, Carlos Enrich, Virginia López, Juan R. Tejedor, Anna Esteve‐Codina, Cristina Núñez de Arenas, Pedro J. Moreno‐Lozano, José C. Milisenda, Mar O'Callaghan, Teresa García‐Silva, Montserrat Morales‐Conejo, Mario F. Fraga, Rafael Artuch, Miguel Á. Martín, José M. Cuezva, Ana Matas, Glòria Garrabou, Mariona Guitart‐Mampel   +24 more
wiley   +1 more source

Characterization of a Fungal Modular Polyketide Synthase System Reveals an Unusual Strategy for Polyketide Chain Initiation

Angewandte Chemie, EarlyView.
Fungal modular polyketide synthases (PKSs) remain largely unexplored. Functional characterization of the LasC/LasD assembly line established its role in strasseriolide C biosynthesis and suggested an unexpected strategy for chain initiation, in which a malonyl unit is transferred from the module 2 acyl carrier protein (ACP) domains to the loading ACP ...
Qiaolin Ji, Chao Peng, Shuhan He, Bin‐Tao Peng, Wei‐Guang Wang, Yudai Matsuda   +5 more
wiley   +2 more sources

Inhibition of Tropomyosin Receptor Kinase B Signaling Alters Hepatic Mitochondrial Enzyme Activity and Oxidative Stress in Mice With Sucrose-Induced Insulin Resistance. [PDF]

J Biochem Mol Toxicol
Bodur A, Zihni HÇ, Korkmaz K, Bodur S, Alver A.   +4 more
europepmc   +1 more source

S11.11 FTIR detection of carboxyl groups in bovine heart cytochrome c oxidase

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2008
Amandine, Maréchal, Rich, Peter R.
openaire   +1 more source