Results 21 to 30 of about 242,283 (275)

Knockdown of prohibitin 2 promotes apoptosis in non-small cell lung cancer cell line A549 [PDF]

open access: yesJichu yixue yu linchuang, 2023
Objective To explore mechanism of prohibitin 2(PHB2) inhibition on the apoptosis of non-small cell lung cancer cell line A549. Methods For stable knockdown of PHB2, A549 strain was infected with lentiviruses. A549 cells with PHB2 depletion were
ZHANG Jing, YANG Zigeng, WEI Hongmei, NING Haihong, XUE Xixi, JIN Ling, WU Bin
doaj   +1 more source

Neat1 decreases neuronal apoptosis after oxygen and glucose deprivation

open access: yesNeural Regeneration Research, 2022
Studies have shown that downregulation of nuclear-enriched autosomal transcript 1 (Neat1) may adversely affect the recovery of nerve function and the increased loss of hippocampal neurons in mice.
Wei-Na Chai   +10 more
doaj   +1 more source

Human chorionic gonadotropin attenuates amyloid-β plaques induced by streptozotocin in the rat brain by affecting cytochrome c-ir neuron density [PDF]

open access: yesIranian Journal of Basic Medical Sciences, 2019
Objective(s): Amyloid β plaques, in Alzheimer’s disease, are deposits in different areas of the brain such as prefrontal cortex, molecular layer of the cerebellum, and the hippocampal formation.
Emsehgol Nikmahzar   +5 more
doaj   +1 more source

Functional state of cardiomyocyte mitochondria in malignant process in presence of comorbid pathology in experiment

open access: yesЮжно-Российский онкологический журнал, 2021
Purpose of the study. An analysis of indices of free radical oxidation and respiration of mitochondria of heart cells in a malignant process in presence of diabetes mellitus and chronic neurogenic pain in experimental animals.Materials and methods.
E. M. Frantsiyants   +12 more
doaj   +1 more source

Heme–Protein Interactions and Functional Relevant Heme Deformations: The Cytochrome c Case

open access: yesMolecules, 2022
Heme proteins are known to perform a plethora of biologically important functions. This article reviews work that has been conducted on various class I cytochrome c proteins over a period of nearly 50 years.
Reinhard Schweitzer-Stenner
doaj   +1 more source

An engineered thermally tolerant apo-cytochrome scaffold for metal-less incorporation of heme derivative.

open access: yesPLoS ONE, 2023
Cytochrome c552 from Thermus thermophilus is one of the hot topics for creating smart biomaterials as it possesses remarkable stability, is tolerant to multiple mutations and has therefore been recently reported for a number of functionalizations upon ...
Sami Ben Aoun, Sheikh Muhammad Ibrahim
doaj   +1 more source

Decoding the role of cytochrome c in metabolism of human spermatozoa by Raman imaging

open access: yesFrontiers in Cell and Developmental Biology, 2022
The normal functioning of sperm cells requires cytochrome c in the redox balanced forms: reduced and oxidized. The oxidized form of cytochrome c is localized in the mitochondrial intermembrane space and is a part of the electron transport chain.
Halina Abramczyk   +4 more
doaj   +1 more source

NMR Study on the Mechanism of Cytochrome c Methionine Oxidation

open access: yesChinese Journal of Magnetic Resonance, 2023
Mitochondria generate reactive oxygen species (ROS) during respiration. Low levels of ROS are conducive to signal transduction, whereas excessive accumulation of ROS can lead to protein oxidative modification.
ZHAO Beibei   +5 more
doaj   +1 more source

Hypericin Enhances Paclitaxel-Induced B16-F10 Cell Apoptosis by Activating a Cytochrome c Release–Dependent Pathway

open access: yesFrontiers in Pharmacology, 2021
The enhanced inhibitory effect of paclitaxel (PTX) combined with hypericin (HY) on B16-F10 cells may be realized through the ROS-related cytochrome c release pathway.
Liyun Sun   +3 more
doaj   +1 more source

CYCLOPHOSPHAMIDE HEPATOTOXICITY: THE ROLE OF 4-HYDROXYNONENAL AND CYTOCHROME C OXIDASE AND THE POSSIBLE PROTECTIVE EFFECT OF GANODERMA LUCIDUM EXTRACT

open access: yesSlovenian Veterinary Research, 2019
Cyclophosphamide (CPA) is a widely used anti-neoplastic drug, but its usage is associated with several side effects including hepatotoxicity. This study was designed to evaluate the ameliorative effect of Ganoderma lucidium (GL) extract as a natural ...
Dina R Gad El-Karim, Gamal El-Amrawi
doaj   +1 more source

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