Results 11 to 20 of about 541,087 (354)
Multiple Mechanisms Regulate Eukaryotic Cytochrome C Oxidase
Cells, 2021 Cytochrome c oxidase (COX), the rate-limiting enzyme of mitochondrial respiration, is regulated by various mechanisms. Its regulation by ATP (adenosine triphosphate) appears of particular importance, since it evolved early during evolution and is still ...
Rabia Ramzan +2 more
doaj +1 more source
Actinorhodin Biosynthesis Terminates with an Unprecedented Biaryl Coupling Reaction
Angewandte Chemie, Volume 135, Issue 5, January 26, 2023., 2023 The last dimerization step of actinorhodin (ACT) biosynthesis was established through biochemical studies. ActVA‐ORF4 is a unique NAD(P)H‐dependent enzyme that catalyzes the biaryl‐coupling reaction using 8‐hydroxydihydrokalafungin (DHK‐OH) as the sole substrate. ActVA‐ORF3 is a quinone‐forming enzyme that forms DHK‐OH and ACT.
Makoto Hashimoto +6 more
wiley +2 more sources
Clinical heterogeneity in a family with flail arm syndrome and review of hnRNPA1‐related spectrum
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1910-1917, December 2022., 2022 Abstract Objective Flail arm syndrome (FAS) is one of the atypical subtypes of amyotrophic lateral sclerosis (ALS). Mutations in hnRNPA1 encoding heterogeneous nuclear ribonucleoprotein (hnRNP) A1 are a rare genetic cause of ALS. Herein, marked clinical heterogeneity of FAS in a pedigree with a known hnRNPA1 variant was described to raise early ...
Xiaochen Han +5 more
wiley +1 more source
Angewandte Chemie, Volume 135, Issue 5, January 26, 2023., 2023 A lyophilized preparation of an unspecific peroxygenase variant from Agrocybe aegerita (rAaeUPO‐PaDa‐I‐H) is a highly effective catalyst for the oxygenation of a diverse range of N‐heterocyclic compounds. Scalable, high yielding and enantioselective biocatalytic oxygenations have been developed, including 27 preparative examples (ca.
Balázs Pogrányi +5 more
wiley +2 more sources
Nature Communications, 2021 Cytochrome c oxidase is a fundamental enzyme of life and its mechanism is not fully understood yet. Here, the authors present four cryo-EM structures of different intermediate states, which suggest an alternative cytochrome c oxidase reaction cycle.
F. Kolbe +5 more
doaj +1 more source
Cytochrome c Oxidase Deficiency [PDF]
Pediatric Research, 1990 Cytochrome c oxidase (COX) is a complex enzyme composed of 13 subunits, three of which are encoded by the mitochondrial DNA (mtDNA). The other 10 subunits are encoded by the nuclear DNA, synthesized in the cytoplasm, and transported into the mitochondria.
Dlmauro S. +9 more
openaire +3 more sources
Rcf1 Modulates Cytochrome c Oxidase Activity Especially Under Energy-Demanding Conditions
Frontiers in Physiology, 2020 The mitochondrial respiratory chain is assembled into supercomplexes. Previously, two respiratory supercomplex-associated proteins, Rcf1 and Rcf2, were identified in Saccharomyces cerevisiae, which were initially suggested to mediate supercomplex ...
Hannah Dawitz +5 more
doaj +1 more source
Multilayered polyelectrolyte microcapsules: interaction with the enzyme cytochrome C oxidase. [PDF]
PLoS ONE, 2014 Cell-sized polyelectrolyte capsules functionalized with a redox-driven proton pump protein were assembled for the first time. The interaction of polyelectrolyte microcapsules, fabricated by electrostatic layer-by-layer assembly, with cytochrome c oxidase
Laura Pastorino +9 more
doaj +1 more source
Activity of respiratory chain cytochrome complexes and cytochromes content in the rat kidney mitochondria under different nutrients content in a diet [PDF]
The Ukrainian Biochemical Journal, 2023 An important role in ensuring the functioning of the respiratory chain belongs to the cytochrome part, which includes complexes III (ubiquinol-cytochrome c oxidoreductase) and IV (cytochrome c oxidase). The key components of these enzymatic complexes are
H. P. Kopylchuk, O. M. Voloshchuk
doaj +1 more source
A biochemical approach to study the role of the terminal oxidases in aerobic respiration in Shewanella oneidensis MR-1. [PDF]
PLoS ONE, 2014 The genome of the facultative anaerobic γ-proteobacterium Shewanella oneidensis MR-1 encodes for three terminal oxidases: a bd-type quinol oxidase and two heme-copper oxidases, a A-type cytochrome c oxidase and a cbb 3-type oxidase.
Sébastien Le Laz +5 more
doaj +1 more source