Results 41 to 50 of about 541,087 (354)
Electrostatic models of electron-driven proton transfer across a lipid membrane [PDF]
J. Phys.: Condens. Matter 23, 234101 (2011), 2010 We present two models for electron-driven uphill proton transport across lipid membranes, with the electron energy converted to the proton gradient via the electrostatic interaction. In the first model, associated with the cytochrome c oxidase complex in the inner mitochondria membranes, the electrostatic coupling to the site occupied by an electron ...
arxiv +1 more source
Mitochondrial cytochrome c oxidase deficiency.
Clinical science, 2016 As with other mitochondrial respiratory chain components, marked clinical and genetic heterogeneity is observed in patients with a cytochrome c oxidase deficiency.
Malgorzata Rak +7 more
semanticscholar +1 more source
Structure of the intact 14-subunit human cytochrome c oxidase
Cell Research, 2018 Respiration is one of the most basic features of living organisms, and the electron transport chain complexes are probably the most complicated protein system in mitochondria.
Shuai Zong +5 more
semanticscholar +1 more source
Mathematical Model for Chemical Reactions in Electrolyte Applied to Cytochrome $c$ Oxidase: an Electro-osmotic Approach [PDF]
arXiv, 2022 A mathematical model for chemical reactions in electrolytes is developed using an Energy variational method consistent with classical thermodynamics. Electrostatics and chemical reactions are included in properly defined energetic and dissipative functionals.
arxiv
Mitochondrial cytochrome c oxidase: catalysis, coupling and controversies.
Biochemical Society Transactions, 2017 Mitochondrial cytochrome c oxidase is a member of a diverse superfamily of haem-copper oxidases. Its mechanism of oxygen reduction is reviewed in terms of the cycle of catalytic intermediates and their likely chemical structures.
P. Rich
semanticscholar +1 more source
EMBO Journal, 2016 Mitochondrial cytochrome c oxidase (CcO) transfers electrons from cytochrome c (Cyt.c) to O2 to generate H2O, a process coupled to proton pumping. To elucidate the mechanism of electron transfer, we determined the structure of the mammalian Cyt.c–CcO ...
S. Shimada +9 more
semanticscholar +1 more source
Loss of the RNA-binding protein TACO1 causes late-onset mitochondrial dysfunction in mice
Nature Communications, 2016 Mutations in the translational activator of cytochrome c oxidase subunit I (TACO1) causes cytochrome c oxidase deficiency and Leigh Syndrome in patients.
Tara R. Richman +11 more
doaj +1 more source
Alterations of sirtuins in mitochondrial cytochrome c-oxidase deficiency. [PDF]
PLoS ONE, 2017 Sirtuins are NAD+ dependent deacetylases, which regulate mitochondrial energy metabolism as well as cellular response to stress. The NAD/NADH-system plays a crucial role in oxidative phosphorylation linking sirtuins and the mitochondrial respiratory ...
Arne Björn Potthast +3 more
doaj +1 more source
Targeting cytochrome C oxidase in mitochondria with Pt(II)-porphyrins for Photodynamic Therapy [PDF]
, 2010 Mitochondria are the power house of living cells, where the synthesis of the chemical "energy currency" adenosine triphosphate (ATP) occurs. Oxidative phosphorylation by a series of membrane protein complexes I to IV, that is, the electron transport chain, is the source of the electrochemical potential difference or proton motive force (PMF) of protons
arxiv +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2016 Significance Cytochrome c oxidase is the last of the enzymes in the mitochondrial electron transport chain and represents a large integral membrane protein complex coupling conversion of molecular oxygen to water with proton translocation across the ...
I. Liko +5 more
semanticscholar +1 more source