Results 71 to 80 of about 396,597 (394)

Rcf1 and Rcf2, Members of the Hypoxia-induced Gene 1 Protein Family, Are Critical Components of the Mitochondrial Cytochrome bc1-cytochrome Oxidase Supercomplex [PDF]

, 2012
We report that Rcf1 (formerly Aim31), a member of the conserved hypoxia-induced gene 1 (Hig1) protein family, represents a novel component of the yeast cytochrome bc1-cytochrome c oxidase (COX) supercomplex.
Furness, Andrew, Garlich, Joshua, Robb-McGrath, Micaela, Strogolova, Vera, Stuart, Rosemary A.   +4 more
core   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

The use of mtCOI gene sequences in identifying Butis species in the Southwest of Vietnam

Heliyon, 2023
Butis genus is characterised by their small body size and morphological variability, allowing them to adapt to different habitats. This paper analyses the mitochondrial cytochrome C oxidase subunit I gene sequences and morphology of Butis for ...
Tran Thi Huyen Lam, Quang Minh Dinh, Van Thi Bich Truong, Ngon Trong Truong, Nam Sy Tran, Ton Huu Duc Nguyen   +5 more
doaj   +1 more source

Reductive activation of potential antitumor bis(aziridinyl)benzoquinones by xanthine oxidase: Competition between oxygen reduction and quinone reduction [PDF]

, 1990
The reduction of a series of 2,5-bis(1-aziridinyl)-1,4-benzoquinone (BABQ) derivatives with various 3,6 substituents by the enzyme xanthine oxidase has been studied.
Janssen, L.H.M., Lusthof, K.J., Mol, N.J. de, Reinhoudt, D.N., Richter, W., Verboom, W.   +5 more
core   +3 more sources

Short‐term actions of epigalocatechin‐3‐gallate in the liver: a mechanistic insight into hypoglycemic and potential toxic effects

FEBS Open Bio, EarlyView.
Epigallocatechin‐3‐gallate (EGCG) acutely inhibited gluconeogenesis and enhanced glycolysis, glycogenolysis, and fatty acid oxidation in perfused rat livers. Mechanistic assays revealed mitochondrial uncoupling, inhibition of pyruvate carboxylation and glucose‐6‐phosphatase, shift of NADH/NAD+ ratios toward oxidation, and loss of membrane integrity ...
Carla Indianara Bonetti, Bruna Lopes Correia, Francielle Cristina Nakamura Manicardi, Nairana Mithieli de Queiroz Eskuarek Melo, Vanesa de Oliveira Pateis, Jurandir Fernando Comar, Anacharis Babeto de Sá‐Nakanishi, Adelar Bracht, Lívia Bracht   +8 more
wiley   +1 more source

Expression and copper binding characteristics of Plasmodium falciparum cytochrome c oxidase assembly factor 11, Cox11

Malaria Journal, 2022
Background Copper is an essential metal for living organisms as a catalytic co-factor for important enzymes, like cytochrome c oxidase the final enzyme in the electron transport chain.
Abdulmalik Abdullahi Salman, J. P. Dean Goldring   +1 more
doaj   +1 more source

A biosynthetic model of cytochrome c oxidase as an electrocatalyst for oxygen reduction

Nature Communications, 2015
Creating an artificial functional mimic of the mitochondrial enzyme cytochrome c oxidase (CcO) has been a long-term goal of the scientific community as such a mimic will not only add to our fundamental understanding of how CcO works but may also pave the
S. Mukherjee, A. Mukherjee, Ambika Bhagi-Damodaran, M. Mukherjee, Yi Lu, A. Dey   +5 more
semanticscholar   +1 more source

Precursors of Cytochrome Oxidase in Cytochrome-Oxidase-Deficient Cells of Neurospora crassa [PDF]

, 1974
Three different cell types of Neurospora crassa deficient in cytochrome oxidase were studied: the nuclear mutant cni-1, the cytoplasmic mutant mi-1 and copper-depleted wild-type cells. * 1.
Ebner E., Ebner E., Edwards D. L., Kiese M., Lansman R., Mason T. L., Mason T. L., Mitchell M. B., Paul K. G., Rifkin M. R., Rubin M. S., Rubin M. S., Schwab A. J., Sebald W., Sebald W., Sebald W., Shakespeare P. G., Warburg O., Weiss H., Werner S., Wohlrab H.   +20 more
core   +1 more source

The Diverse Neuromuscular Spectrum of VPS13A Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective VPS13A disease (chorea‐acanthocytosis) is a rare neurodegenerative disorder caused by biallelic variants in VPS13A, typically presenting with hyperkinetic movement disorders, while neuromuscular signs are often mild. The aim of the project was to investigate the frequency and severity of neuromuscular impairment in VPS13A disease ...
Anne Buchberger, Evamaria Riedel, Marie Hackenberg, Alexander Mensch, Stefanie Beck‐Woedl, Joohyun Park, Tobias B. Haack, Bernhard Haslinger, Jan Kirschke, Holger Prokisch, Andreas Hermann, Christian Mawrin, Adrian Danek, Benedikt Schoser, Kevin Peikert, Marcus Deschauer, Isabell Cordts   +16 more
wiley   +1 more source

DNA barcoding suggested the existence of cryptic species and high biodiversity of South Korean pseudoscorpions (Arachnida, Pseudoscorpiones)

Journal of Asia-Pacific Biodiversity, 2018
Pseudoscorpions are one of the common arthropod in soil mesofauna but are infrequently studied in East Asia. The fauna in South Korea is not adequate enough, and practical faunistic survey of pseudoscorpions have not been conducted in last 20 years.
Hajime Ohira, Koichi Sato, Tadaaki Tsutsumi, Shingo Kaneko, Hyeok-Jae Choi   +4 more
doaj   +1 more source