Results 11 to 20 of about 69,108 (276)

Engineering ascorbate peroxidase activity into cytochrome c peroxidase. [PDF]

Biochemistry, 2008
Cytochrome c peroxidase (CCP) and ascorbate peroxidase (APX) have very similar structures, and yet neither CCP nor APX exhibits each other's activities with respect to reducing substrates. APX has a unique substrate binding site near the heme propionates where ascorbate H-bonds with a surface Arg and one heme propionate (Sharp et al. (2003) Nat. Struct.
Meharenna YT, Oertel P, Bhaskar B, Poulos TL.   +3 more
europepmc   +4 more sources

Tyrosine 67 Phosphorylation Controls Respiration and Limits the Apoptotic Functions of Cytochrome c [PDF]

Cells
Cytochrome c (Cytc) is a multifunctional protein, essential for respiration and intrinsic apoptosis. Post-translational modifications of Cytc have been linked to physiological and pathophysiologic conditions, including cancer. Cytc tyrosine 67 (Y67) is a
Junmei Wan, Paul T. Morse, Matthew P. Zurek, Alice A. Turner, Asmita Vaishnav, Arthur R. Salomon, Brian F. P. Edwards, Tasnim Arroum, Maik Hüttemann   +8 more
doaj   +2 more sources

Oxidative markers and SOD variant: predictors of autism severity and susceptibility [PDF]

Future Science OA
Background This study examines the relationship between oxidative stress, anti-oxidative markers, and the Ala16Val SOD2 polymorphism in children with autism spectrum disorder (ASD) to better understand ASD severity and susceptibility.Material and methods
Abdullah Abubaker Shareef, Azad Hasan Kheder, Niaz Albarzinji, Karim Jalal Karim, Shukur Wasman Smail, Abubakr Abdalla Mahmood, Kawa Amin   +6 more
doaj   +2 more sources

The role and mechanism of the cGAS–STING pathway-mediated ROS in apoptosis and ferroptosis induced by manganese exposure [PDF]

Redox Biology
Environmental exposure to elevated manganese (Mn) levels is significantly associated with neurocognitive deficits, attracting widespread attention, yet its underlying mechanisms remain incompletely defined.
Zhimin Zhang, Jirui Yang, Qiongli Zhou, Shiyin Zhong, Jinghao Luo, Xueting Chai, Jingjing Liu, Xin Zhang, Xuhong Chang, Hui Wang   +9 more
doaj   +2 more sources

The effect of cardiolipin side chain composition on cytochrome c protein conformation and peroxidase activity

Physiological Reports, 2021
Skeletal muscle, a highly active tissue, makes up 40% of the total body weight. This tissue relies on mitochondria for ATP production, calcium homeostasis, and programed cell death.
Jennifer A. Wilkinson, Sebastian Silvera, Paul J. LeBlanc   +2 more
doaj   +1 more source

Multiple Mutations in the Non-Ordered Red Ω-Loop Enhance the Membrane-Permeabilizing and Peroxidase-like Activity of Cytochrome c

Biomolecules, 2022
A key event in the cytochrome c-dependent apoptotic pathway is the permeabilization of the outer mitochondrial membrane, resulting in the release of various apoptogenic factors, including cytochrome c, into the cytosol.
Rita V. Chertkova, Alexander M. Firsov, Nadezda A. Brazhe, Evelina I. Nikelshparg, Zhanna V. Bochkova, Tatyana V. Bryantseva, Marina A. Semenova, Adil A. Baizhumanov, Elena A. Kotova, Mikhail P. Kirpichnikov, Georgy V. Maksimov, Yuriy N. Antonenko, Dmitry A. Dolgikh   +12 more
doaj   +1 more source

Manganese oxidation counteracts the deleterious effect of low temperatures on biofilm formation in Pseudomonas sp. MOB-449

Frontiers in Molecular Biosciences, 2022
Mn removal from groundwater by biological sand filter technology is negatively impacted by low temperatures in winter periods. Therefore, the need to study Mn(II)-oxidizing bacteria (MOB) having the potential to oxidize Mn(II) and form biofilms at low ...
Lucila Ciancio Casalini, Ainelen Piazza, Fiorella Masotti, Betiana S. Garavaglia, Jorgelina Ottado, Natalia Gottig   +5 more
doaj   +1 more source

Peroxidase Activity of Cytochrome c [PDF]

Bulletin of the Korean Chemical Society, 2004
, deferoxamine (DFX)and ethylenediamine tetraacetic acid (EDTA) were pur-chased from Sigma. The diammonium salt of 2,2'-azinobis-(3-ethylbenzthiazoline-6-sulfonate) (ABTS) was obtainedfrom Boehringer Mannheim. Chelex 100 resin (sodiumform) was obtained from Bio-Rad. All materials weretreated with Chelex 100 resin.
Moon Sik Jeong, Soo Young Choi, Jung Hoon Kang, Namhoon Kim   +3 more
openaire   +2 more sources

Dually Cross-Linked Core-Shell Structure Nanohydrogel with Redox–Responsive Degradability for Intracellular Delivery

Pharmaceutics, 2021
A redox-responsive nanocarrier is a promising strategy for the intracellular drug release because it protects the payload, prevents its undesirable leakage during extracellular transport, and favors site-specific drug delivery.
Siyuan Deng, Maria Rosa Gigliobianco, Emin Mijit, Marco Minicucci, Manuela Cortese, Barbara Campisi, Dario Voinovich, Michela Battistelli, Sara Salucci, Pietro Gobbi, Giulio Lupidi, Giorgia Zambito, Laura Mezzanotte, Roberta Censi, Piera Di Martino   +14 more
doaj   +1 more source

Use of in-gel peroxidase assay for cytochrome c to visualize mitochondrial complexes III and IV

Biology Open, 2020
The in-gel activity assay (IGA) is a powerful technique that uses enzymatic activity and compares intensities of detected bands in mitochondrial respiratory chain supercomplexes, and it is applicable to eukaryotic organisms.
Tsukasa Hara, Yuma Shibata, Ryosuke Amagai, Ayako Okado-Matsumoto   +3 more
doaj   +1 more source