Results 21 to 30 of about 138,479 (226)

Multiple Mutations in the Non-Ordered Red Ω-Loop Enhance the Membrane-Permeabilizing and Peroxidase-like Activity of Cytochrome c

Biomolecules, 2022
A key event in the cytochrome c-dependent apoptotic pathway is the permeabilization of the outer mitochondrial membrane, resulting in the release of various apoptogenic factors, including cytochrome c, into the cytosol.
Rita V. Chertkova, Alexander M. Firsov, Nadezda A. Brazhe, Evelina I. Nikelshparg, Zhanna V. Bochkova, Tatyana V. Bryantseva, Marina A. Semenova, Adil A. Baizhumanov, Elena A. Kotova, Mikhail P. Kirpichnikov, Georgy V. Maksimov, Yuriy N. Antonenko, Dmitry A. Dolgikh   +12 more
doaj   +1 more source

Molecular Basis and Consequences of the Cytochrome c-tRNA Interaction. [PDF]

, 2016
The intrinsic apoptosis pathway occurs through the release of mitochondrial cytochrome c to the cytosol, where it promotes activation of the caspase family of proteases.
Christian, Thomas, Hou, Ya-Ming, Liu, Cuiping, Stonestrom, Aaron J, Takase, Ryuichi, Yang, Xiaolu, Yong, Jeongsik   +6 more
core   +2 more sources

The Met80Ala and Tyr67His/Met80Ala mutants of human cytochrome cshed light on the reciprocal role of Met80 and Tyr67 in regulating ligand access into the heme pocket. [PDF]

, 2017
The spectroscopic and functional properties of the single Met80Ala and double Tyr67His/Met80Ala mutants of human cytochrome c have been investigated in their ferric and ferrous forms, and in the presence of different ligands, in order to clarify the ...
Battista, T, Cervelli, M, Ciaccio, C, Coletta, M, Fiorucci, L, Howes, B, Mariottini, P, Santucci, R, Smulevich, G, Tognaccini, L   +9 more
core   +1 more source

Manganese oxidation counteracts the deleterious effect of low temperatures on biofilm formation in Pseudomonas sp. MOB-449

Frontiers in Molecular Biosciences, 2022
Mn removal from groundwater by biological sand filter technology is negatively impacted by low temperatures in winter periods. Therefore, the need to study Mn(II)-oxidizing bacteria (MOB) having the potential to oxidize Mn(II) and form biofilms at low ...
Lucila Ciancio Casalini, Ainelen Piazza, Fiorella Masotti, Betiana S. Garavaglia, Jorgelina Ottado, Natalia Gottig   +5 more
doaj   +1 more source

Structural and functional characterization of phosphomimetic mutants of cytochrome c at threonine 28 and serine 47 [PDF]

, 2016
Protein function is frequently modulated by post-translational modifications of specific residues. Cytochrome c, in particular, is phosphorylated in vivo at threonine 28 and serine 47.
Díaz-Moreno, Irene, Díaz-Quintana, Antonio, Guerra-Castellano, Alejandra, Rosa, Miguel A. de la, Velázquez-Campoy, Adrián   +4 more
core   +1 more source

Use of in-gel peroxidase assay for cytochrome c to visualize mitochondrial complexes III and IV

Biology Open, 2020
The in-gel activity assay (IGA) is a powerful technique that uses enzymatic activity and compares intensities of detected bands in mitochondrial respiratory chain supercomplexes, and it is applicable to eukaryotic organisms.
Tsukasa Hara, Yuma Shibata, Ryosuke Amagai, Ayako Okado-Matsumoto   +3 more
doaj   +1 more source

Cytochrome c signalosome in mitochondria [PDF]

, 2011
Cytochrome c delicately tilts the balance between cell life (respiration) and cell death (apoptosis). Whereas cell life is governed by transient electron transfer interactions of cytochrome c inside the mitochondria, the cytoplasmic adducts of cytochrome
Díaz Moreno, Irene, Díaz Quintana, Antonio Jesús, García Heredia, José Manuel, Rosa Acosta, Miguel Ángel de la   +3 more
core   +1 more source

Dually Cross-Linked Core-Shell Structure Nanohydrogel with Redox–Responsive Degradability for Intracellular Delivery

Pharmaceutics, 2021
A redox-responsive nanocarrier is a promising strategy for the intracellular drug release because it protects the payload, prevents its undesirable leakage during extracellular transport, and favors site-specific drug delivery.
Siyuan Deng, Maria Rosa Gigliobianco, Emin Mijit, Marco Minicucci, Manuela Cortese, Barbara Campisi, Dario Voinovich, Michela Battistelli, Sara Salucci, Pietro Gobbi, Giulio Lupidi, Giorgia Zambito, Laura Mezzanotte, Roberta Censi, Piera Di Martino   +14 more
doaj   +1 more source

Role of lysines in cytochrome c – cardiolipin interaction [PDF]

, 2013
Cytochrome c undergoes structural variations during the apoptotic process; such changes have been related with modifications occurring in the protein when it forms a complex with cardiolipin, one of the phospholipids constituting the mitochondrial ...
Coletta, M, Di Pierro, D, Droghetti, E, Fiorucci, L, Howes, B, Piro, MC, Polticelli, F, Santucci, R, Sinibaldi, F, Smulevich, G   +9 more
core   +1 more source

Effects of Laser Radiation on Mitochondria and Mitochondrial Proteins Subjected to Nitric Oxide

Frontiers in Medicine, 2018
The biological roles of heme and nonheme nitrosyl complexes in physiological and pathophysiological conditions as metabolic key players are considered in this study. Two main physiological functions of protein nitrosyl complexes are discussed—(1) a depot
Anatoly N. Osipov, Tatiana V. Machneva, Evgeny A. Buravlev, Evgeny A. Buravlev, Yury A. Vladimirov, Yury A. Vladimirov   +5 more
doaj   +1 more source