Results 1 to 10 of about 4,757 (93)
Association of polymorphism of CYP2D6 and CYP2C9 genes encoding P-450 proteins of cytochrome with arterial hypertension [PDF]
Саратовский научно-медицинский журнал, 2012 Gene polymorphisms of cytochrome P-450 CYP2 encoding proteins of cytochrome P-450 are essential forantihy-pertensive drugs metabolism. Purpose: We study the associations of functionally defective allele variants of CYP2D6 gene and CYP2C9 gene with the ...
Saratsev A.V. +7 more
doaj +1 more source
Differential effects of 2C9*3 and 2C9*2 variants of cytochrome P-450 CYP2C9 on sensitivity to acenocoumarol [PDF]
Blood, 2002 The 2C9*3 and 2C9*2 polymorphisms of cytochrome P-450 CYP2C9 are associated with hypersensitivity to warfarin and bleeding. The effect of these polymorphisms on sensitivity to acenocoumarol is unknown. Three groups of patients, with low, medium, or high acenocoumarol-dose requirements, were studied. Age influenced the acenocoumarol sensitivity. Bearing
Rocha, E. (Eduardo) +6 more
+6 more sources
Possible algorithms for determining adverse reactions caused by food supplements in Romania
One Health & Risk Management, 2021 Introduction. The advertising of food supplements on various media channels or in specialty stores with natural products and other places, as well as the lack of informative and educational programs for the population upon side effects and the ...
Irina Mihaela MATRAN +4 more
doaj +3 more sources
Медицинский совет, 2021 Non-steroidal anti-inflammatory drugs (NSAIDs) are the most common drugs in clinical practice and account for 5–10% of all drugs prescribed each year.
K. M. Muratov +3 more
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Неотложная медицинская помощь, 2020 Relevance. One of the key components of the accelerated recovery protocols (ARP), in addition to minimizing the surgical approach, is an adequate postoperative analgesia.
A. A. Muradyan +7 more
doaj +1 more source
The interactions between COVID-19 drugs and psychotropic agents
European Psychiatry, 2021 Coronavirus disease (COVID-19) is a systemic infection targeting multiple organs. Interstitial pneumonia is the landmark feature of this condition. Severe acute respiratory symptoms requiring intensive care support arises for about one out of twenty ...
C. Hiemke
doaj +1 more source
Effect of hesperetin on the pharmacokinetics of metoprolol succinate in rats
Future Journal of Pharmaceutical Sciences, 2023 Background Metoprolol is a substrate of CYP3A4, 2B6, CYP2D6, CYP2C9, and p-glycoprotein (p-gp). Hesperetin was reported as an inhibitor of cytochrome P-450 (CYP) enzymes and p-gp. The objective of this study was to investigate the effect of hesperetin on
Ravindra Babu Pingili +5 more
doaj +1 more source
Российский кардиологический журнал, 2018 Aim. To assess the clinical, biochemical, and genetic risk factors for the development of hepatocyte cytolysis syndrome in patients with a combination of fatty liver disease and recrudescence of chronic cardiovascular pathology.Material and methods.
N. V. Kokh +4 more
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Pharmacology Research & Perspectives, 2020 Very little is known to which extent severe underweight could affect cytochrome P‐450 (CYP) enzyme activity. In this study, 24 patients with anorexia nervosa at two occasions ingested single oral doses of five test drugs known to be metabolized by CYP1A2,
Pål Sandvik +3 more
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Research in Pharmaceutical Sciences, 2018 Polymorphism in the genes encoding CYP2C9 enzyme and VKORC1 reductase significantly influence warfarin dose requirement since patients with CYP2C9*2, CYP2C9*3 and VKORC1 mutant alleles require lower warfarin maintenance doses.
Zohreh Hosseinkhani +7 more
doaj +1 more source