Results 21 to 30 of about 4,757 (93)

Integrated Anatomical, Chemical, Biological and Computational Studies Approach of Myrcia sylvatica (G. Mey) DC. A Multifaceted Insight Into a Promising Amazonian Species

Flavour and Fragrance Journal, Volume 41, Issue 2, Page 270-293, March 2026.
This study presents an integrated anatomical, chemical, biological, and computational analysis of Myrcia sylvatica, revealing key bioactive compounds with antioxidant and toxicological potential, and identifying spathulenol and globulol as promising acetylcholinesterase inhibitors with favourable pharmacokinetic properties. ABSTRACT Myrcia sylvatica (G.
Eliza de Jesus Barros dos Santos, Zelina Ataíde Correia, Ely Simone Cajueiro Gurgel, Leonardo Souza da Costa, Mabrouk Horchani, Hayet Edziri, Ravendra Kumar, Anderson de Santana Botelho, Karyme do Socorro de Souza Vilhena, Eloisa Helena de Aguiar Andrade, Mozaniel Santana de Oliveira   +10 more
wiley   +1 more source

An Evaluation of the Drug Interaction Potential of Encorafenib in Combination With Binimetinib Using the Inje Cocktail in Patients With Cancer

Clinical Pharmacology &Therapeutics, Volume 119, Issue 2, Page 375-380, February 2026.
A clinical drug–drug interaction (DDI) study was designed to evaluate the effect of single and multiple oral doses of encorafenib on the single oral dose pharmacokinetics (PK) of the cytochrome P450 (CYP) enzyme probe substrates, losartan (CYP2C9), midazolam (CYP3A4), caffeine (CYP1A2), omeprazole (CYP2C19), and dextromethorphan (CYP2D6) administered ...
Joseph Piscitelli, Micaela B. Reddy, Lance Wollenberg, Laurence Del Frari, Jason Gong, Kyle Matschke, Jason H. Williams   +6 more
wiley   +1 more source

Influence of CYP450 Enzymes and ABCB1 Polymorphisms on Clopidogrel Response in Moroccan Patients with Acute Coronary Syndromes

Pharmacogenomics and Personalized Medicine, 2023
Ismail Mouhrach,1,2 Laila Bouguenouch,2,3 Adil Kamal,3,4 Abbassi Meriame,2 Nada El Khorb,3,4 Mohammed El Azami El Idrissi,3 Hafid Akoudad,3,4 Hicham Bekkari1 1Laboratory of Biotechnology, Environment, Agrifood, and Health, Faculty of Sciences Dhar El ...
Mouhrach I, Bouguenouch L, Kamal A, Meriame A, El Khorb N, El Azami El Idrissi M, Akoudad H, Bekkari H   +7 more
doaj  

Deconvoluting Gut Versus Liver Cytochrome P450 3A4 Function: Drug Probes, Biomarkers, and Tissue Biopsy

The Journal of Clinical Pharmacology, Volume 66, Issue 2, February 2026.
Abstract Cytochrome P450 3A4 (CYP3A4) is an important drug‐metabolizing enzyme, whose function is impacted by age, sex, body weight, pregnancy, and disease. It is also the site of major drug interactions involving inhibition and induction. Because CYP3A4 is expressed in the intestine and liver, investigators have sought to study its function in both ...
David Rodrigues
wiley   +1 more source

Economic Impact of the Application of a Precision Medicine Model (5SPM) on Psychotic Patients

Pharmacogenomics and Personalized Medicine, 2021
Lorena Carrascal-Laso,1 Manuel Ángel Franco-Martín,1 Elena Marcos-Vadillo,2 Ignacio Ramos-Gallego,3 Belén García-Berrocal,2 Eduardo Mayor-Toranzo,1 Santiago Sánchez-Iglesias,4 Carolina Lorenzo,4 Alfonso Sevillano-Jiménez,1 Almudena Sánchez-Martín,5 María
Carrascal-Laso L, Franco-Martín M, Marcos-Vadillo E, Ramos-Gallego I, García-Berrocal B, Mayor-Toranzo E, Sánchez-Iglesias S, Lorenzo C, Sevillano-Jiménez A, Sánchez-Martín A, García-Salgado MJ, Isidoro-García M   +11 more
doaj  

Coumarin‐Augmented Thiazole Hybrids as Dual Anticancer and Antibacterial Agents

Chemical Biology &Drug Design, Volume 107, Issue 2, February 2026.
Compound 13, a coumarin‐thiazole hybrid, is shown engaging the ATP‐binding site of S. aureus GyrB through a novel hydrogen bond with residue SER129. The molecule exhibits dual antibacterial and anticancer activity, supporting its potential as a dual‐target topoisomerase inhibitor.
Islam K. Matar, Magdi E. A. Zaki, Zeinab A. Muhammad, Dahlia A. Awwad, Sami A. Al‐Hussain, Chérif F. Matta, Refaie M. Kassab   +6 more
wiley   +1 more source

9‐Deoxymuzigadial, a Sesquiterpene Isolated From Drimys brasiliensis (Winteraceae), Displays Reduced Cytotoxicity In Vitro and Modulates Leukocyte Activity and Fibrogenesis In Vivo

Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.
ABSTRACT The aims of this study were to investigate in vitro cytotoxic potential and the effects of daily administration during the inflammatory response induced by sponge implants in mice of the sesquiterpene 9‐deoxymuzigadial (9‐DOM), isolated from Drimys brasiliensis (Winteraceae).
Bruno Antonio Ferreira, Isabella Silva Cassimiro, Francyelle Borges Rosa de Moura, Tais de Campos Lima, Danielle Reis Napolitano, Eric Umehara, João Henrique Ghilardi Lago, Fernanda de Assis Araújo   +7 more
wiley   +1 more source

ASSOCIATION OF POLYMORPHISM IN BIOTRANSFORMATION SYSTEM GENES CYP1A1 AND GST WITH RISK OF RELAPSE IN CHILDHOOD ACUTE LEUKEMIA

Педиатрическая фармакология, 2007
Presence of polymorphism in genes coding biotransformation system may play an important role in formation of primary childhood acute leukemia, and affects the incidence and features of relapse.
O.A. Gra
doaj   +2 more sources

Photophysical and DNA‐Binding Properties of Phenoxazine‐Based Push–Pull Type Organic Chromophores: Insights From DFT, Molecular Docking, and Optical Studies

ChemistryOpen, Volume 15, Issue 1, January 2026.
This study investigates the interaction of phenoxazine‐based organic dyads (PO1, PO2, PO4, and PO5) with calf thymus DNA using UV–visible spectroscopy, theoretical HOMO–LUMO analysis, and molecular docking techniques. The results reveal strong DNA‐binding interactions of these dyads, particularly PO5, highlighting their potential in biochemical and ...
Praveen Naik, T Aravinda, Kuruvalli Gouthami, Vaddi Damodara Reddy, B Vinay Kumar, Neela H. Yennawar, Kavya S. Keremane   +6 more
wiley   +1 more source

Toward Integrative Predictive Toxicology: Advanced Methods for Drug Toxicity and Safety Prediction

WIREs Computational Molecular Science, Volume 16, Issue 1, January/February 2026.
This figure summarizes the different methods in integrative predictive toxicology reviewed in this work, ranging from exploration of molecular mechanisms to in silico pharmacokinetic modeling and construction of adverse outcome pathway (AOP) networks based on key events (KEs) and key event relationships (KERs). Further integration with multi‐omics data
Eleonora Gianquinto, Matteo Bersani, Lucrezia Armando, Lara Davani, Clara Cena, Angela De Simone, Francesca Spyrakis   +6 more
wiley   +1 more source