Results 141 to 150 of about 6,342 (159)

Functional High Level Expression of Cytochrome P450 CYP2D6 Using Baculoviral Expression Systems

Archives of Biochemistry and Biophysics, 1996
Cytochrome P-450 CYP2D6 plays a central role in the metabolism of many widely used therapeutic drugs including β-adrenergic antagonists, antiarrhythmics, and tricyclic antidepressants.
Mark J I Paine, Gordon C K Roberts, C R Wolf   +2 more
exaly   +2 more sources

Cytochrome P-450 activities in human and rat brain microsomes

Brain Research, 2000
The role of cytochrome P450 in the metabolism of dextromethorphan, amitriptyline, midazolam, S-mephenytoin, citalopram, fluoxetine and sertraline was investigated in rat and human brain microsomes. Depending on the parameters, the limit of quantification
Marianne J Reymond, Constantin Bouras, Henry W Strobel   +2 more
exaly   +2 more sources

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Correlation between cytochrome P-450 CYP2D6 (CYP2D6) genotype and phenotype.

Zhongguo yao li xue bao = Acta pharmacologica Sinica, 2000
To study the correlation between CYP2D6 genotype and its phenotype.CYP2D6 genotyping was made by detecting CYP2D6*3, *4, *6, and *7 alleles with an allele-specific polymerase chain reaction procedure.The CYP2D6 genotypes were well correlated with its phenotypes in all 125 extensive metabolizers and in 43 poor metabolizers. Extensive metabolizers had at
S Q, Chen, P J, Wedlund
openaire   +1 more source

Parkinson disease and cytochrome P-450 CYP2D6 genetic polymorphism

2000
We investigated the association of inactive CYP2D6 alleles *3, *4, *6, *7 and *8 with Parkinson disease (PD). Genotyping of the 41 patients and 145 healthy volunteers was performed by multiplex-allele specific PCR. Patient's phenotype was predicted from genotypes: extensive metabolizer (EM, two wild-type alleles), poor metabolizer (PM, two deficiency ...
Relja, Maja, Štefanović, Mario, Topić, Elizabeta, KORŠIĆ, MARTA   +3 more
openaire   +2 more sources

Susceptibility to astrocytoma and meningioma: influence of allelism at glutathione S-transferase (GSTT1 and GSTM1) and cytochrome P-450 (CYP2D6) loci.

Cancer research, 1995
We describe a case-control study to identify associations between polymorphism at the cytochrome P-450 (CYP2D6) and glutathione S-transferase (GSTT1 and GSTM1) loci and susceptibility to astrocytoma and meningioma. Accordingly, genotype frequencies in 112 astrocytoma and 50 meningioma patients were compared with frequencies in 577 controls.
J, Elexpuru-Camiruaga, N, Buxton, V, Kandula, P S, Dias, D, Campbell, J, McIntosh, J, Broome, P, Jones, A, Inskip, J, Alldersea   +9 more
openaire   +1 more source

[Anti-cytochrome P 450 2D6 antibody(CYP2D6 antibody)].

Nihon rinsho. Japanese journal of clinical medicine, 2010
Nobuyuki, Amino, Mako, Fujiwara
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[Immunological tests: Anti-cytochrome P 450 2D6 antibody (CYP2D6 antibody)].

Nihon rinsho. Japanese journal of clinical medicine, 2005
Nobuyuki, Amino, Sumihisa, Kubota
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Impacts of Cytochrome P450 2D6 (CYP2D6) Genetic Polymorphism in Tamoxifen Therapy for Breast Cancer

Revista Brasileira De Ginecologia E Obstetricia, 2018
Lucas Soares Bezerra, Marcelo Antonio Oliveira Santos-Veloso   +1 more
exaly  

Influence of amino acid residue 374 of cytochrome P-450 2D6 (CYP2D6) on the regio- and enantio-selective metabolism of metoprolol

Biochemical Journal, 1996
S Wynne Ellis, M J Ackland, Eleni Rekka
exaly  

Competition Between Cytochrome P-450 Isozymes for NADPH-Cytochrome P-450 Oxidoreductase Affects Drug Metabolism

Journal of Pharmacology and Experimental Therapeutics, 1999
Michael P Pritchard, Brian Burchell, Thomas Friedberg   +2 more
exaly