Results 151 to 160 of about 32,368 (172)

Genetic variants in tamoxifen metabolism and early treatment discontinuation among premenopausal breast cancer patients. [PDF]

Breast Cancer Res Treat
Woolpert KM, Ahern TP, Baurley JW, Maliniak ML, Damkier P, Kjærsgaard A, Collin LJ, Hamilton-Dutoit S, Tramm T, Ejlertsen B, Sørensen HT, Lash TL, Cronin-Fenton DP.   +12 more
europepmc   +1 more source

Effect of Antipsychotic Drugs on Human Liver Cytochrome P-450 (CYP) Isoforms In Vitro: Preferential Inhibition of CYP2D6

Drug Metabolism and Disposition, 1999
The ability of antipsychotic drugs to inhibit the catalytic activity of five cytochrome P-450 (CYP) isoforms was compared using in vitro human liver microsomal preparations to evaluate the relative potential of these drugs to inhibit drug metabolism. The apparent kinetic parameters for enzyme inhibition were determined by nonlinear regression analysis ...
J G, Shin, N, Soukhova, D A, Flockhart
semanticscholar   +4 more sources

Involvement of CYP2D6, CYP3A4, and other cytochrome P-450 isozymes in N-dealkylation reactions

Journal of Pharmacological and Toxicological Methods, 1994
Metabolic N-dealkylation is a commonly observed biotransformation with tertiary and secondary amine drugs and related N-alkylated amides, but surprisingly little is known about the cytochrome P-450 isozymes involved in these dealkylation reactions.
R T, Coutts, P, Su, G B, Baker
semanticscholar   +4 more sources

Azelastine N-Demethylation by Cytochrome P-450 (CYP)3A4, CYP2D6, and CYP1A2 in Human Liver Microsomes: Evaluation of Approach to Predict the Contribution of Multiple CYPs

Drug Metabolism and Disposition, 1999
Azelastine, an antiallergy and antiasthmatic drug, has been reported to be mainly N-demethylated to desmethylazelastine in humans. In the present study, Eadie-Hofstee plots of azelastine N-demethylation in human liver microsomes were biphasic. In microsomes from human B-lymphoblast cells, recombinant cytochrome P-450 (CYP)2D6 and CYP1A1 exhibited ...
M, Nakajima, S, Nakamura, S, Tokudome, N, Shimada, H, Yamazaki, T, Yokoi   +5 more
semanticscholar   +4 more sources

Capillary electrophoretic investigation of the enantioselective metabolism of propafenone by human cytochrome P‐450 SUPERSOMES: Evidence for atypical kinetics by CYP2D6 and CYP3A4

ELECTROPHORESIS, 2006
AbstractAn enantioselective CE method was used to identify the ability of CYP450 enzymes and their stereoselectivity in catalyzing the transformation of propafenone (PPF) to 5‐hydroxy‐propafenone (5OH‐PPF) and N‐despropyl‐propafenone (NOR‐PPF). Using in vitro incubations with single CYP450 enzymes (SUPERSOMES), 5OH‐PPF is shown to be selectively ...
Minoo, Afshar, Wolfgang, Thormann
semanticscholar   +4 more sources

Susceptibility to astrocytoma and meningioma: influence of allelism at glutathione S-transferase (GSTT1 and GSTM1) and cytochrome P-450 (CYP2D6) loci.

Cancer research, 1995
We describe a case-control study to identify associations between polymorphism at the cytochrome P-450 (CYP2D6) and glutathione S-transferase (GSTT1 and GSTM1) loci and susceptibility to astrocytoma and meningioma. Accordingly, genotype frequencies in 112 astrocytoma and 50 meningioma patients were compared with frequencies in 577 controls.
J, Elexpuru-Camiruaga, N, Buxton, V, Kandula, P S, Dias, D, Campbell, J, McIntosh, J, Broome, P, Jones, A, Inskip, J, Alldersea   +9 more
openaire   +2 more sources

[Anti-cytochrome P 450 2D6 antibody(CYP2D6 antibody)].

Nihon rinsho. Japanese journal of clinical medicine, 2010
Nobuyuki, Amino, Mako, Fujiwara
openaire   +2 more sources

[Immunological tests: Anti-cytochrome P 450 2D6 antibody (CYP2D6 antibody)].

Nihon rinsho. Japanese journal of clinical medicine, 2005
Nobuyuki, Amino, Sumihisa, Kubota
openaire   +2 more sources

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Role and pharmacologic significance of cytochrome P‐450 2D6 in oxidative metabolism of toremifene and tamoxifen

International Journal of Cancer, 2013
We investigated the in vitro metabolism and estrogenic and antiestrogenic activity of toremifene (TOR), tamoxifen (TAM) and their metabolites to better understand the potential effects of cytochrome P‐450 2D6 (CYP2D6) status on the activity of these ...
Juhyun Kim, C. Coss, C. Barrett, Michael L Mohler, Casey E. Bohl, Chien-Ming Li, Yali He, K. Veverka, J. Dalton   +8 more
semanticscholar   +1 more source

: pharmacogenetics; drug toxicity; cytochrome P-450 enzyme system; TPMT; genetic testing

Paediatria Croatica, 2013
Varijabilnosti u učinku lijeka mogu se djelomično objasniti genetičkim razlikama. Postoje interindividualne razlike u metaboličkom itransportnom kapacitetu i detoksikaciji lijekova i drugih ksenobiotika.
Nada Božina, L. Pejnović
semanticscholar   +1 more source