Food Science &Nutrition, Volume 13, Issue 8, August 2025.Atriplex halimus extracts exhibited significant antidiabetic activity, notably inhibiting α‐amylase and hemoglobin glycation. UHPLC‐MS/MS analysis identified 21 phytochemicals, with trans‐cinnamic acid being the most abundant. Molecular docking revealed catechin and epigallocatechin as key bioactive compounds with strong binding affinities, surpassing ...
Mohammed Roubi +10 more
wiley +1 more source
Drug Exposure in Chronic Kidney Disease: It Is Not Just About the Glomerular Filtration Rate
Fundamental &Clinical Pharmacology, Volume 39, Issue 4, Page 1-10, August 2025.ABSTRACT Chronic kidney disease (CKD) affects over 10% of the world's population and is associated with high morbidity and mortality rates. The management of CKD is complex; CKD alters drug pharmacokinetics and pharmacodynamics and further complicates therapeutic strategies regimens.
Sophie Liabeuf +6 more
wiley +1 more source
Cancer Innovation, Volume 4, Issue 3, June 2025.ABSTRACT Background The phosphoinositide 3‐kinase (PI3K)/protein kinase B (PKB or AKT)/mammalian target of rapamycin (mTOR) signaling pathway (PAM pathway) plays a critical role in breast cancer pathogenesis and progression, and is closely linked with resistance to endocrine therapy in advanced breast cancer.
The Breast Cancer Expert Committee of the National Quality Control Center for Cancer +3 more
wiley +1 more source
CYP2D6 Genotype and Tamoxifen Response in Postmenopausal Women with Endocrine-Responsive Breast Cancer: The Breast International Group 1-98 Trial [PDF]
, 2017 Background Adjuvant tamoxifen therapy is effective for postmenopausal women with endocrine-responsive breast cancer. Cytochrome P450 2D6 (CYP2D6) enzyme metabolizes tamoxifen to clinically active metabolites, and CYP2D6 polymorphisms may adversely affect
Biasi, Maria Olivia +19 more
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Clinical Pharmacology &Therapeutics, Volume 117, Issue 6, Page 1784-1792, June 2025.Psychedelics, such as psilocybin and lysergic acid diethylamide (LSD), are being investigated for the treatment of depressive and anxiety disorders, for which concomitant treatment with selective serotonin reuptake inhibitors (SSRIs) is prevalent.
Anna M. Becker +12 more
wiley +1 more source
Cytochrome P450 enzyme mediated herbal drug interactions (Part 2) [PDF]
, 2014 To date, a number of significant herbal drug interactions have their origins in the alteration of cytochrome P450 (CYP) activity by various phytochemicals. Among the most noteworthy are those involving St.
Phopin, Kamonrat +2 more
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A service improvement project to review prescribing information provided by general practitioners for new referrals to a UK National Health Service hospital pain clinic: potential implications of CYP2D6 enzyme inhibition. [PDF]
, 2016 INTRODUCTION: Chronic pain is often managed using co-prescription of analgesics and adjuvants, with concomitant medication prescribed for comorbidities.
Fitzgerald, P +3 more
core +1 more source
Itraconazole-induced Torsade de Pointes in a patient receiving methadone substitution therapy [PDF]
, 2009 Issues. Methadone, a pharmacological agent used to treat heroin dependence is relatively safe, but may cause cardiac arrhythmias in the concurrent presence of other risk factors. Approach and Key Findings.
Narayanan, S. +2 more
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Current evidence for a modulation of low back pain by human genetic variants [PDF]
, 2009 The manifestation of chronic back pain depends on structural, psychosocial, occupational and genetic influences. Heritability estimates for back pain range from 30% to 45%. Genetic influences are caused by genes affecting intervertebral disc degeneration
Aberle +200 more
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Effect of the inhibition of CYP3A4 or CYP2D6 on the pharmacokinetics and pharmacodynamics of oxycodone [PDF]
, 2018 Purpose: The main metabolic pathways of oxycodone, a potent opioid analgetic, are N-demethylation (CYP3A4) to inactive noroxycodone and O-demethylation (CYP2D6) to active oxymorphone.
Drewe, Jürgen +5 more
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