Results 81 to 90 of about 6,342 (159)

A role for Cyp2d6 in nicotine metabolism?

, 2001
Nicotine is known to be metabolised to its major metabolite cotinine by members of the cytochrome P450 monooxygenase superfamily. Although CYP2A6 has now been identified as the principal enzyme which catalyses this biotransformation, CYP2D6 is also an ...
Smith, Gillian; id_orcid, Sachse, Christoph   +1 more
core   +1 more source

Acute dystonic reaction to metoclopramide in patients carrying homozygous cytochrome P-450 2D6 genetic polymorphisms [PDF]

, 2006
Background: Extrapyramidal syndromes (EPS) are clinically relevant side effects of metoclopramide which are often not anticipated.Patients and methods: Two patients who received metoclopramide developed an acute dystonic reaction.Symptoms disappeared ...
Sonneveld, P., van der Padt, Annemieke, van Schaik, Ron   +2 more
core  

Role of cytochrome P450 genotype in the steps toward personalized drug therapy

, 2011
Larisa H Cavallari1,2, Hyunyoung Jeong1,2, Adam Bress11Department of Pharmacy Practice, 2Department of Biopharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USAAbstract: Genetic polymorphism for cytochrome 450 ...
Jeong H, Cavallari LH, Bress A
core  

An observational study of Venlafaxine and CYP2D6 in clinical practice.

, 2014
Background: Venlafaxine (V) is a serotonin-norepinephrine selective reuptake inhibitor, mainly metabolized by cytochrome P4502D6 (CYP2D6). CYP2D6 polymorphisms result in a variety of phenotypes: poor (PMs), intermediate (IMs), extensive (EMs), and ...
ROLLA, Roberta, Prosperini P, VIDALI, Matteo, Pollarolo P, BELLOMO, Giorgio, ZEPPEGNO, Patrizia, Meola S, Gramaglia C, Ressico F, Dalò V, Torre E   +10 more
core  

Effects of CYP2D6 and CYP3A5 polymorphisms on tamoxifen and its metabolites in Thai breast cancer patients

, 2017
Wanaporn Charoenchokthavee,1 Nutthada Areepium,2 Duangchit Panomvana,2 Virote Sriuranpong2 1Department of Pharmacy Practice, Faculty of Pharmaceutical Science, Chulalongkorn University, 2Medical Oncology Unit, Department of Medicine, Faculty of Medicine,
Charoenchokthavee W, Areepium N, Panomvana D, Sriuranpong V   +3 more
core  

CYP2D6 polymorphisms and the safety and gametocytocidal activity of single dose primaquine for P. falciparum

, 2019
Single dose primaquine (PQ) clears mature gametocytes and reduces transmission of Plasmodium falciparum after artemisinin combination therapy. Genetic variation in CYP2D6, the gene producing the drug metabolizing enzyme cytochrome P450 2D6 (CYP2D6 ...
Alassane Dicko (22536), Teun Bousema (79969), Joseph Okebe (265299), Chris Drakeley (79962), Anna-Liina Mustaniemi (16275716), Umberto D'Alessandro (80990), Helmi Pett (3537080), Bronner P Gonçalves (14778985), Will Stone (317660), John Bradley (484108), Mikko Neuvonen (15170003), Mikko Niemi (4759761), Kjerstin Lanke (264378), Chi Eziefula (4467568), Alfred B Tiono (16272455), Ingrid Chen (846287), Roly Gosling (79963)   +16 more
core  

Evaluation of the cytochrome P450-mediated drug interaction profile of olorofim. [PDF]

Antimicrob Agents Chemother
Cornelissen K, Rex JH, Zinzi D, Law D, Upcott Gill R, Jones HM, Maertens J, Chen SC-A, Brüggemann R.   +8 more
europepmc   +1 more source

Associations of CYP2B6, CYP2C19, and CYP2D6 isoforms and phenoconversion with sertraline pharmacokinetics. [PDF]

PLoS One
Tapia-Alzuguren B, Canga-Espina C, Molero P, Aldaz A.   +3 more
europepmc   +1 more source

Integrating Genetic Variants and Expression Profiles of Pharmacogenes to Investigate Resistance to Antidepressant Treatment. [PDF]

Medicina (Kaunas)
Pisanu C, Squassina A, Perera-Bel J, Silva RC, Buson L, Sires AM, Bortolomasi M, Menesello V, Perusi G, Carpiniello B, Ferensztajn-Rochowiak E, Rybakowski F, Sanz F, Manchia M, Potier MC, Dierssen M, Prompt Study Group, Baune BT, Gennarelli M, Minelli A.   +19 more
europepmc   +1 more source

Cardiovascular prescriber attitudes to pharmacogenomics: a survey by the ESC working group on cardiovascular pharmacotherapy. [PDF]

Pharmacogenomics J
Magavern EF, Dan GA, Savarese G, Borghi C, Dobrev D, Tamargo J, Ferdinandy P, McDermott JH, Newman WG, Pirmohamed M, Caulfield MJ, Kaski JC.   +11 more
europepmc   +1 more source