Results 71 to 80 of about 6,342 (159)

In vitro interactions between medicinal drugs and herbs on Cytochrome P-450 metabolism and P-glycoprotein transport [PDF]

, 2007
Omsetningen av naturlegemidler og kosttilskudd har økt dramatisk de siste årene, og en økende aksept for urtebruk tilsier at forbruket fortsatt vil øke. Samtidig bruk av naturlegemidler/urter og legemidler forekommer ofte.
Hellum, Bent Håvard
core  

The Effects of Pharmacogenetics on Pharmacokinetics\ud of Artemisinin-Based Combinations in Malaria Patients [PDF]

, 2009
Malaria is a vector-borne infectious disease caused by protozoan parasites of the genus Plasmodium. If not treated appropriately, human P. falciparum malaria can quickly become life-threatening, leading to an estimated 900’000 annual deaths globally. Key
Hodel, Eva Maria
core  

Cytochrome P-450 2d6*10 C188t Polymorphism Is Associated with Antipsychotic-Induced Persistent Tardive Dyskinesia in Chinese Schizophrenic Patients

, 2009
Typical antipsychotic treatment had been postulated to be a risk factor for the susceptibility to tardive dyskinesia (TD ). The cytochrome P-450 debrisoquine/sparteine hydroxylase ( CYP2D6) metabolizes a majority of antipsychotics and exhibits various ...
BAI, YA-MEI;LIN, CHAO-CHENG, 白雅美;林朝誠   +1 more
core  

Pharmacogenetics of African populations : variation in major drug metabolising enzyme genes and potential impact on personalised medicine.

, 2009
Includes bibliographical references (leaves 167 ...
Matimba, Alice
core  

Обзор существующих методик оценки активности CYP2D6 с применением экзогенных и эндогенных маркеров

, 2014
Peculiarities of functioning and polymorphism of cytochrome P450 isoenzyme CYP2D6. Existing methods for determining its activity using endogenous markers.
Г. Н. Гильдеева, Рустем Хамзиевич Абдрашитов, G. N. Gildeeva, A. D. Abdrashitov, V. V. Smirnov, Г. В. Раменская, В. В. Смирнов, G. V. Ramenskaya   +7 more
core  

Влияние изофермента CYP2D6 на метаболизм лекарственных препаратов и методы определения его активности

, 2018
The article presents relevant information on the features of cytochrome P450 isoenzyme CYP2D6 functioning. 20-25% of drugs are metabolized by the action of CYP2D6.
R. A. Permyakov, E. A. Egorenkov, R. H. Abdrashitov, Рустем Хамзиевич Абдрашитов, G. N. Gildeeva, Гэлия Нязыфовна Гильдеева, Галина Владиславовна Раменская, V. V. Smirnov, Валерий Валерьевич Смирнов, Роман Александрович Пермяков, Евгений Андреевич Егоренков, G. V. Ramenskaya   +11 more
core  

Functionally active duplications of the CYP2D6 gene are more prevalent among larynx and lung cancer patients

, 2001
The cytochrome P450 CYP2D6 is a polymorphic drug-metabolizing enzyme that is involved in the metabolism of several drugs and xenobiotics. Several independent studies indicate that the CYP2D6 metabolic status is a secondary factor in the risk of ...
Lozano, Luis, Ledesma, María C., Rodriguez-Lescure, Alvaro, Pontes, José C., Benítez, Julio, Iglesias Moreno, María Cruz, Gallardo, Lourdes, Agúndez, JA, Poch Broto, Joaquín, Ladero, José M.   +9 more
core   +1 more source

Identification of the primary gene defect at the cytochrome P₄₅₀ CYP2D locus

, 1990
THE mammalian cytochrome P450-dependent monooxygenase system is involved in the metabolism of drugs and chemical carcinogens1-5. The role of these enzymes in toxicological response is exemplified by an autosomal recessive polymorphism at the cytochrome ...
Spurr, Nigel K., C. Roland Wolf, Eichelbaum, Michel, Gaedigk, Andrea, Nigel K. Spurr, Andrea Gaedigk, Moss, Julie E., Julie E. Moss, Michel Eichelbaum, Miles, John S., John S. Miles, Gough, Alan C., Wolf, C. Roland, Alan C. Gough   +13 more
core   +1 more source

Impact of the CYP2D6 utrarapid metabolizer genotype on mirtazapine pharmacokinetics and adverse events in healthy volunteers

, 2004
Introduction: In vitro studies showed that biotransformation of the antidepressant drug mirtazapine is mediated by cytochrome P-450 enzymes CYP1A2, CYP2D6, and CYP3A4 with CYP2D6 contributing about 35% to total mirtazapine biotransformation.
Henckel, H. B., Brockmoller, A., Kirchheiner, Julia, Roots, Ivar, Meineke, Ingolf   +4 more
core   +1 more source

Functional characterization of wild-type and 24 CYP2D6 allelic variants on gefitinib metabolism in vitro

, 2017
Ping Fang,1 Xiang Zheng,1 Jiayang He,1 Honglei Ge,1 Pengfei Tang,1 Jianping Cai,2 Guoxin Hu1 1Department of Pharmacology, School of Pharmacy, Wenzhou Medical University, Wenzhou, Zhejiang, 2The Ministry of Health (MOH) Key Laboratory of Geriatrics ...
Ge HL, Cai JP, Zheng X, He JY, Hu GX, Fang P, Tang PF   +6 more
core