Results 51 to 60 of about 6,342 (159)

Pharmacovigilance‐Based Identification and Mechanistic Exploration of Periodontitis‐Related Drugs

Journal of Clinical Periodontology, Volume 53, Issue 1, Page 117-126, January 2026.
ABSTRACT Background Periodontitis is a common chronic inflammatory disease. However, drug‐related risks and underlying molecular mechanisms remain underexplored from large real‐world data. Methods We first mined the US Food and Drug Administration Adverse Event Reporting System (FAERS) database to identify drugs disproportionately associated with ...
Wuda Huoshen, Junkai Xiong, Xunmi Ma, Heng Wang, Panyu Cheng, Xinyu Chen, Ge Shuai, Yi Chen, Xinyue Zhang, Chen Sun, Chunhui Li, Rui Shi   +11 more
wiley   +1 more source

Allelic and phenotypic characterization of CYP2D6 and its encoded P450 cytochrome enzyme in a serie of Spanish type 1 Gaucher disease patients [PDF]

, 2020
Background: Cytochrome p450 is the main drug metabolic pathway. CYP2D6 is a highly polymorphic gene that encodes a cytochrome p450 enzyme with three activity levels: null, reduced and normal.
Irún, P., Giraldo, P., Alfonso, P., López de Frutos, L., Lahoz, C.   +4 more
core   +1 more source

In Silico Investigation of Dual‐Target Quorum Sensing Inhibitors to Eradicate Biofilm Formation in Candida albicans

Cellular Microbiology, Volume 2026, Issue 1, 2026.
Candida albicans (C. albicans) is an opportunistic yeast that forms biofilms, which confer increased resistance to antifungal agents, making infections very difficult to treat. One of the mechanisms regulating this virulence is quorum sensing (QS), which can be defined as a cellular communication mechanism based on the production of autoinducer, namely,
Doha EL Meskini, Fettouma Chraa, Taoufiq Benali, Rachid El Jaoudi, Mouna Ouadghiri, Abdelhakim Bouyahya, Hooi Leng Ser, Bey Hing Goh, Tarik Aanniz, Anirudha Chattopadhyay   +9 more
wiley   +1 more source

Rational Design of Pyrazole–Chalcone Congeners via Enumeration: Insights From Molecular Docking, MM‐GBSA, Pharmacophore Modelling, MD Simulations and DFT Calculations

Journal of Chemistry, Volume 2026, Issue 1, 2026.
Background Monoamine oxidase‐B (MAO‐B) is a pivotal enzyme in the pathophysiology of Parkinson’s disease (PD), where its elevated activity accelerates dopamine catabolism, increases oxidative stress and contributes to the progressive loss of dopaminergic neurons.
Zakiya Fathima C., Jainey P. James, Srinivas Ganjipete, Parasuraman Pavadai, Sindhu T. J., Sohini Basu Roy   +5 more
wiley   +1 more source

Antimicrobial Activities of Crocatin B From Piper crocatum as an Antithroat Infection: In Vitro and In Silico Studies

Journal of Chemistry, Volume 2026, Issue 1, 2026.
Throat infections are primarily caused by pathogenic bacteria such as Streptococcus pyogenes, whereas opportunistic fungi such as Candida albicans can infect the oropharyngeal area in conditions of weakened immune systems. Increasing antimicrobial resistance supports the exploration of alternative antimicrobial agents derived from natural sources ...
Ditta Atsna Nuriya Salsabila, Tati Herlina, Dikdik Kurnia, Munmun Bardhan   +3 more
wiley   +1 more source

Functional co-expression of CYP2D6 and human NADPH-cytochrome P450 reductase in Escherichia coli

, 1998
The polymorphic human CYP2D6 has been co-expressed with human NADPH-cytochrome P450 oxidoreductase in Escherichia coli in order to generate a functional recombinant monooxygenase system for the study of xenobiotic metabolism.
Friedberg, Thomas, Pritchard, Michael P., Blake, Jennifer A R, Gilham, David E., Glancey, Michael J., Burchell, Brian, Wolf, C. Roland   +6 more
core   +1 more source

ASSOCIATION OF POLYMORPHISM IN BIOTRANSFORMATION SYSTEM GENES CYP1A1 AND GST WITH RISK OF RELAPSE IN CHILDHOOD ACUTE LEUKEMIA

Педиатрическая фармакология, 2007
Presence of polymorphism in genes coding biotransformation system may play an important role in formation of primary childhood acute leukemia, and affects the incidence and features of relapse.
O.A. Gra
doaj   +2 more sources

Evaluation of Antioxidant and Enzyme Inhibitory Properties of Cinnamaldehyde: In Vitro and In Silico Investigations

Journal of Chemistry, Volume 2026, Issue 1, 2026.
Cinnamaldehyde, a bioactive compound derived from cinnamon plants, has demonstrated various biological capacities, i.e., antimicrobial, antidiabetic, antiobesity, and anticancer efficiencies. Here, the potential antioxidant, anticholinesterase, anti‐α‐amylase, anti‐α‐glucosidase, and antityrosinase activities of cinnamaldehyde were investigated by ...
Jihane Touhtouh, Mustapha Laghmari, Taoufiq Benali, Tarik Aanniz, Khaoula Habbadi, Gokhan Zengin, Hooi-Leng Ser, Khang Wen Goh, Bey-Hing Goh, Abdelhakim Bouyahya, Khalil Hammani, Sohini Basu Roy   +11 more
wiley   +1 more source

Breaking tolerance to the natural human liver autoantigen cytochrome P450 2D6 by virus infection

, 2009
Autoimmune hepatitis (AIH) is a chronic liver disease of unknown etiology, characterized by a loss of tolerance against hepatocytes leading to the progressive destruction of hepatic parenchyma and cirrhosis. Clinical signs for AIH are interface hepatitis
Holdener, Martin
core  

CYP2D6 genotype dependent oxycodone metabolism in postoperative patients. [PDF]

, 2013
BACKGROUND: The impact of polymorphic cytochrome P450 CYP2D6 enzyme on oxycodone's metabolism and clinical efficacy is currently being discussed. However, there are only spare data from postoperative settings.
Musshoff, Frank, Malte Book, Zhang, Lan, Frank Musshoff, Lan Zhang, Ulrike M Stamer, Lehmann, Lutz E., Book, Malte, Stuber, Frank, Lutz E Lehmann, Frank Stuber, Stamer, Ulrike M.   +11 more
core   +1 more source