Results 31 to 40 of about 24,208,296 (151)

Wild Daucus carota Subsp. maximus: Phytochemicals, Bioactivities, and Pharmacokinetic Insights for Future Food and Therapeutic Applications

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
Wild Daucus carota subsp. Maximus: chemical investigation and biological assessment. ABSTRACT Daucus carota subsp. maximus, a biennial plant from the Apiaceae family, is valued for its aromatic properties. It is the largest wild carrot subspecies found in Algeria, characterized by its tall stem, triangular leaves, and large umbels.
Maroua Hadji, Khadidja Dehimi, Fethi Farouk Kebaili, Tahar Smaili, Toka Hadji, Larbi Derbak, Ilyas Yildiz, Fehmi Boufahja, Hamdi Bendif, Tarek H. Taha, Walid Elfalleh, Stefania Garzoli   +11 more
wiley   +1 more source

Breaking tolerance to the natural human liver autoantigen cytochrome P450 2D6 by virus infection [PDF]

, 2009
Autoimmune hepatitis (AIH) is a chronic liver disease of unknown etiology, characterized by a loss of tolerance against hepatocytes leading to the progressive destruction of hepatic parenchyma and cirrhosis. Clinical signs for AIH are interface hepatitis
Holdener, Martin
core  

Comprehensive Phytochemical Profiling and Multi‐Target Biological Evaluation of Hibiscus sabdariffa L. Calyx Extracts From Libya: A Promising Functional Food Candidate With Antibacterial, Antioxidant, Anti‐Inflammatory, and Cytotoxic Properties: Validation Through In Silico Approaches

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
This study presents a comprehensive evaluation of Hibiscus sabdariffa L. calyx extracts from Libya, integrating phytochemical profiling, multi‐target biological activities, and in silico validation. Aqueous and ethanolic extracts were prepared and assessed for antibacterial activity against multidrug‐resistant clinical isolates (MIC: 6.25–25 mg/mL; MBC/
Ahmed Saeed Kabbashi, Zuhir S. Mussa Akrim, Mohammed B. Suliman, Sanadelaslam S. A. El‐Hddad, Ahmed Ali Mustafa, Maryam Mohammed Ibrahim, Esraa Radwan Ibrahim, Mona Rafea Mosa, Rama Burhan Hasan   +8 more
wiley   +1 more source

Multimodal Multiorgan‐on‐a‐Chip Platform for Probing Liver‐Tumor Interactions and Advancing Prodrug Screening

Advanced Science, Volume 13, Issue 34, 19 June 2026.
This work introduces a multimodal multi‐OoC platform that overcomes current limitations in liver‐tumor interaction studies and prodrug screening. By integrating dynamic microfluidic circuits, electrochemical sensing, and mass analysis, this platform enables non‐invasive, longitudinal monitoring of drug metabolism and hepatotoxicity, offering a ...
Dan Wang, Yisong Huang, Weijian Zhao, Tian Chen, Siyu Bai, Denghui Guo, Mengying Wang, Yaoyao Zhao, Liang Zhao, Guangsheng Guo, Xiayan Wang   +10 more
wiley   +1 more source

One-electron reduction of mitomycin c by rat liver: role of cytochrome P-450 and NADPH-cytochrome P-450 reductase

, 1990
1. The role of cytochrome P-450 in the one-electron reduction of mitomycin c was studied in rat hepatic microsomal systems and in reconstituted systems of purified cytochrome P-450.
Vromans, R M, Van de Straat, R, Groeneveld, M., Vermeulen, N P, Vermeulen, N P; id_orcid   +4 more
core   +1 more source

Biological and In Silico Evaluation of Novel Methoxyphenol–1,2,3‐Triazole Hybrids as Multifunctional Anti‐Alzheimer's and Anticancer Agents

Chemical Biology &Drug Design, Volume 107, Issue 6, June 2026.
Novel methoxyphenol‐1,2,3‐triazole hybrids were synthesized as multifunctional leads. Compound 5e exhibited potent PC3 cytotoxicity (IC50: 3.57 μM), while 5c showed superior AChE inhibition (IC50: 1.44 μM) and high selectivity (SI: 6.22). DFT and docking studies confirmed their dual‐targeting potential, providing a robust scaffold for Alzheimer's and ...
Sultan Onur, Mustafa Çeşme, Ferhan Tümer   +2 more
wiley   +1 more source

Cannabinoids and drug–drug pharmacokinetic interactions: Deciphering the risks

British Journal of Clinical Pharmacology, Volume 92, Issue 5, Page 1287-1308, May 2026.
The relationship between cannabinoids and mental health has become a major focus of scientific inquiry and public discourse. Cannabinoids are diverse chemical compounds from the Cannabis species that have been explored for their therapeutic applications in treating chronic pain, psychiatric and neurological conditions, such as depression, schizophrenia,
Paraskevi Papakyriakopoulou, Georgia Valsami, Georgios Ismailos   +2 more
wiley   +1 more source

A Novel Cytochrome P-450 which Catalyze ω-Hydroxylation of Prostaglandins [PDF]

, 1988
P(論文)Two forms of cytochrome P-450, designated as cytochrome P-450p-1 and P-450p-2, were separted and purified from lung microsomes of rabbits treated with progesterone.
41791, 山本, 覚
core  

Modulation of Tau Protein Neurotoxic Hallmarks by Novel σ1R Agonists/HDAC Inhibitor Dual‐Acting Compounds

ChemMedChem, Volume 21, Issue 5, 13 March 2026.
This study explores the development of dual‐acting compounds combining σ1R agonists and histone deacetylase inhibitors (HDACi). Key findings include compound 2d and 3a's high affinity for σ1R and favorable pharmacokinetic profile and an in vivo determined σ1R agonist profile by reversing the effect of the σ1R antagonist BD‐1063.
Antonino N. Fallica, Carla Barbaraci, M. Carmen Ruiz‐Cantero, Arianna Scarlatti, Alessandro Coco, Giorgia Giordano, Alfonsina La Mantia, Orazio Prezzavento, Antonio Di Stefano, Ivana Cacciatore, Giacomo Siano, Antonino Cattaneo, Lorella Pasquinucci, Enrique J. Cobos, Cristina Di Primio, Emanuele Amata, Agostino Marrazzo   +16 more
wiley   +1 more source

Cytochrome P-450 in drug-resistance Mycobacterium tuberculosis [PDF]

, 1999
Methods for the isolation and spectrophotometric determination of cytochrome P-450 in mycobacteria were standardized. Cytochrome P-450 levels were estimated in Mycobacterium tuberculosis organisms sensitive to both isoniazid and rifampicin and resistant ...
Ramachandran, G, Narayanan, P R, Gurumurthy, P, Mahadevan, U   +3 more
core   +2 more sources