Results 21 to 30 of about 6,342 (159)

Molecular simulations on proteins of biomedical interest : A. Ligand-protein hydration B. Cytochrome P450 2D6 and 2C9 C. Myelin associated glycoprotein (MAG) [PDF]

, 2011
TOPIC 1: Water molecules mediating polar interactions in ligand–protein complexes contribute to both binding affinity and specificity. To account for such water molecules in computer-aided drug discovery, we performed an extensive search in the Cambridge
Rossato, Gianluca
core   +1 more source

Genetic risk factors of cytolysis syndrome in the treatment of recrudescence of chronic cardiovascular diseases

Российский кардиологический журнал, 2018
Aim. To assess the clinical, biochemical, and genetic risk factors for the development of hepatocyte cytolysis syndrome in patients with a combination of fatty liver disease and recrudescence of chronic cardiovascular pathology.Material and methods.
N. V. Kokh, E. N. Voronina, T. V. Efremova, G. S. Soldatova, G. I. Lifshits   +4 more
doaj   +1 more source

Effect of hesperetin on the pharmacokinetics of metoprolol succinate in rats

Future Journal of Pharmaceutical Sciences, 2023
Background Metoprolol is a substrate of CYP3A4, 2B6, CYP2D6, CYP2C9, and p-glycoprotein (p-gp). Hesperetin was reported as an inhibitor of cytochrome P-450 (CYP) enzymes and p-gp. The objective of this study was to investigate the effect of hesperetin on
Ravindra Babu Pingili, Sridhar Vemulapalli, Surya Sandeep Mullapudi, Vijaya R. Dirisala, Harsha Sai Chanumolu, Naveen Babu Kilaru   +5 more
doaj   +1 more source

A Single Site Population Study to Investigate CYP2D6 Phenotype of Patients with Persistent Non-Malignant Pain

Medicina, 2019
Background and Objectives: Codeine requires biotransformation by the CYP2D6 enzyme, encoded by the polymorphic CYP2D6 gene, to morphine for therapeutic efficacy. CYP2D6 phenotypes of poor, intermediate, and ultra-rapid metabolisers are at risk of codeine
Helen Radford, Karen H. Simpson, Suzanne Rogerson, Mark I. Johnson   +3 more
doaj   +1 more source

Metabolism of six CYP probe substrates in fetal hepatocytes

ADMET and DMPK, 2016
Cytochrome P-450 (CYP) are the most common drug metabolizing enzymes and are abundantly expressed in liver apart from kidney, lungs, intestine, brain etc. Their expression levels change with physiological conditions and disease states.
Abdul Naveed Shaik, Sandeep Kumar Vishwakarma, Aleem A Khan   +2 more
doaj   +1 more source

Role of CYP2D6 Gene Variants and Family History in Personalized Antidepressant Treatments for Depression

Korean Journal of Clinical Laboratory Science
Depression is a globally prevalent mental health disorder characterized by significant variability in the treatment responses owing to genetic, environmental, and familial factors.
Minji KO, Yumin KIM, Hanbyeol CHOI, Ho-Keun CHOI   +3 more
doaj   +1 more source

The CYP2D6 animal model: how to induce autoimmune hepatitis in mice

, 2012
Autoimmune hepatitis is a rare but life threatening autoimmune disease of the liver of unknown etiology1,2. In the past many attempts have been made to generate an animal model that reflects the characteristics of the human disease 3-5.
Christen, Urs, Hintermann, Edith, Ehser, Janine   +2 more
core   +1 more source

Primaquine ineligibility in anti-relapse therapy of Plasmodium vivax malaria: the problem of G6PD deficiency and cytochrome P-450 2D6 polymorphisms

Malaria Journal, 2018
The hypnozoite reservoir of Plasmodium vivax represents both the greatest obstacle and opportunity for ultimately eradicating this species. It is silent and cannot be diagnosed until it awakens and provokes a clinical attack with attendant morbidity ...
J. Kevin Baird, Katherine E. Battle, Rosalind E. Howes   +2 more
doaj   +1 more source

Effects of and its Bioactive Phytochemical Constituent Lupeol on Hepatic Phase I Drug Metabolism

Natural Product Communications, 2017
There are many possible complications associated with the concomitant use of herbs and medications, but limited information is available on herb-herb or herb-drug interactions. Paederia foetida Linn.
Sourabh Dubey, Kuntal Mitra, Bijoy Kumar De, Arijit Mondal, Anupam Bishayee   +4 more
doaj   +1 more source

Cannabinoids and drug–drug pharmacokinetic interactions: Deciphering the risks

British Journal of Clinical Pharmacology, Volume 92, Issue 5, Page 1287-1308, May 2026.
The relationship between cannabinoids and mental health has become a major focus of scientific inquiry and public discourse. Cannabinoids are diverse chemical compounds from the Cannabis species that have been explored for their therapeutic applications in treating chronic pain, psychiatric and neurological conditions, such as depression, schizophrenia,
Paraskevi Papakyriakopoulou, Georgia Valsami, Georgios Ismailos   +2 more
wiley   +1 more source