Results 41 to 50 of about 5,525 (123)

Pharmacokinetic and pharmacodynamic characteristics of aripiprazole

Psychiatry and Clinical Psychopharmacology, 2021
Efforts have continued to introduce new antipsychotics with different mechanisms of action following the clinical use of typical antipsychotics for the last fifty years. Among all atypical antipsychotics, aripiprazole has attracted attention since it is
Haldun Soygür
doaj  

Photophysical and DNA‐Binding Properties of Phenoxazine‐Based Push–Pull Type Organic Chromophores: Insights From DFT, Molecular Docking, and Optical Studies

ChemistryOpen, Volume 15, Issue 1, January 2026.
This study investigates the interaction of phenoxazine‐based organic dyads (PO1, PO2, PO4, and PO5) with calf thymus DNA using UV–visible spectroscopy, theoretical HOMO–LUMO analysis, and molecular docking techniques. The results reveal strong DNA‐binding interactions of these dyads, particularly PO5, highlighting their potential in biochemical and ...
Praveen Naik, T Aravinda, Kuruvalli Gouthami, Vaddi Damodara Reddy, B Vinay Kumar, Neela H. Yennawar, Kavya S. Keremane   +6 more
wiley   +1 more source

Toward Integrative Predictive Toxicology: Advanced Methods for Drug Toxicity and Safety Prediction

WIREs Computational Molecular Science, Volume 16, Issue 1, January/February 2026.
This figure summarizes the different methods in integrative predictive toxicology reviewed in this work, ranging from exploration of molecular mechanisms to in silico pharmacokinetic modeling and construction of adverse outcome pathway (AOP) networks based on key events (KEs) and key event relationships (KERs). Further integration with multi‐omics data
Eleonora Gianquinto, Matteo Bersani, Lucrezia Armando, Lara Davani, Clara Cena, Angela De Simone, Francesca Spyrakis   +6 more
wiley   +1 more source

Hyperfiltration and Metabolism Before and After a Low‐Calorie, Pre‐Gastric Bypass Surgery Diet: Significance for Concentrations of Hydrophilic and Lipophilic Drugs

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 1, January 2026.
ABSTRACT Psychotropic drug concentrations increase/decrease with hydrophilicity/lipophilicity after a low‐calorie pre‐bariatric surgery diet. To investigate underlying mechanisms, body weight and serum creatinine/cystatin C changes over the diet period were characterized and suggested to reflect changes in glomerular filtration and metabolic capacity ...
Magnus A. B. Axelsson, Susanna M. Wallerstedt   +1 more
wiley   +1 more source

Managing the Complex Intersection Between Substance Use Disorders and Infectious Diseases

JACCP: JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY, Volume 9, Issue 3, March 2026.
Karissa Chow, Amanda Binkley, Jessica Meisner, Samantha Huo, Matthew Hinton   +4 more
wiley   +1 more source

Pharmacovigilance‐Based Identification and Mechanistic Exploration of Periodontitis‐Related Drugs

Journal of Clinical Periodontology, Volume 53, Issue 1, Page 117-126, January 2026.
ABSTRACT Background Periodontitis is a common chronic inflammatory disease. However, drug‐related risks and underlying molecular mechanisms remain underexplored from large real‐world data. Methods We first mined the US Food and Drug Administration Adverse Event Reporting System (FAERS) database to identify drugs disproportionately associated with ...
Wuda Huoshen, Junkai Xiong, Xunmi Ma, Heng Wang, Panyu Cheng, Xinyu Chen, Ge Shuai, Yi Chen, Xinyue Zhang, Chen Sun, Chunhui Li, Rui Shi   +11 more
wiley   +1 more source

In Silico Investigation of Dual‐Target Quorum Sensing Inhibitors to Eradicate Biofilm Formation in Candida albicans

Cellular Microbiology, Volume 2026, Issue 1, 2026.
Candida albicans (C. albicans) is an opportunistic yeast that forms biofilms, which confer increased resistance to antifungal agents, making infections very difficult to treat. One of the mechanisms regulating this virulence is quorum sensing (QS), which can be defined as a cellular communication mechanism based on the production of autoinducer, namely,
Doha EL Meskini, Fettouma Chraa, Taoufiq Benali, Rachid El Jaoudi, Mouna Ouadghiri, Abdelhakim Bouyahya, Hooi Leng Ser, Bey Hing Goh, Tarik Aanniz, Anirudha Chattopadhyay   +9 more
wiley   +1 more source

ASSOCIATION OF POLYMORPHISM IN BIOTRANSFORMATION SYSTEM GENES CYP1A1 AND GST WITH RISK OF RELAPSE IN CHILDHOOD ACUTE LEUKEMIA

Педиатрическая фармакология, 2007
Presence of polymorphism in genes coding biotransformation system may play an important role in formation of primary childhood acute leukemia, and affects the incidence and features of relapse.
O.A. Gra
doaj   +2 more sources

Rational Design of Pyrazole–Chalcone Congeners via Enumeration: Insights From Molecular Docking, MM‐GBSA, Pharmacophore Modelling, MD Simulations and DFT Calculations

Journal of Chemistry, Volume 2026, Issue 1, 2026.
Background Monoamine oxidase‐B (MAO‐B) is a pivotal enzyme in the pathophysiology of Parkinson’s disease (PD), where its elevated activity accelerates dopamine catabolism, increases oxidative stress and contributes to the progressive loss of dopaminergic neurons.
Zakiya Fathima C., Jainey P. James, Srinivas Ganjipete, Parasuraman Pavadai, Sindhu T. J., Sohini Basu Roy   +5 more
wiley   +1 more source

Antimicrobial Activities of Crocatin B From Piper crocatum as an Antithroat Infection: In Vitro and In Silico Studies

Journal of Chemistry, Volume 2026, Issue 1, 2026.
Throat infections are primarily caused by pathogenic bacteria such as Streptococcus pyogenes, whereas opportunistic fungi such as Candida albicans can infect the oropharyngeal area in conditions of weakened immune systems. Increasing antimicrobial resistance supports the exploration of alternative antimicrobial agents derived from natural sources ...
Ditta Atsna Nuriya Salsabila, Tati Herlina, Dikdik Kurnia, Munmun Bardhan   +3 more
wiley   +1 more source