Pharmacokinetic Evaluation of Clozapine in Concomitant Use of Radix Rehmanniae, Fructus Schisandrae, Radix Bupleuri, or Fructus Gardeniae in Rats [PDF]
, 2016 : Radix Rehmanniae, Fructus Schisandrae, Radix Bupleuri, and Fructus Gardeniae are often used alongside with clozapine (CLZ) for schizophrenia patients in order to reduce side effects and enhance therapeutic efficacy.
Sze, CWS +4 more
core +1 more source
Drug Design, Development and Therapy, 2018 Dmitrij A Sychev,1 Ghulam Md Ashraf,2 Andrey A Svistunov,3 Maksim L Maksimov,4 Vadim V Tarasov,3 Vladimir N Chubarev,3 Vitalij A Otdelenov,1 Natal’ja P Denisenko,1 George E Barreto,5,6 Gjumrakch Aliev7–9 1Russian Medical Academy of ...
Sychev DA +9 more
doaj
An Extensively Humanized Mouse Model to Predict Pathways of Drug Disposition and Drug/Drug Interactions, and to Facilitate Design of Clinical Trials [PDF]
, 2019 Species differences in drug metabolism and disposition can confound the extrapolation of in vivo pharmacokinetic data to man, and also profoundly compromise drug efficacy studies due to differences in pharmacokinetics, in metabolites produced (which are ...
A. Rode +21 more
core +3 more sources
Arg296 to Cys296 polymorphism in exon 6 of cytochrome P-450-2D6 (CYP2D6) is not associated with multiple system atrophy. [PDF]
Journal of Neurology, Neurosurgery & Psychiatry, 1995 O, Bandmann +3 more
openaire +2 more sources
Genetic polymorphism and drug interactions: their importance in the treatment of pain [PDF]
, 2018 Résumé: Objectif: Evaluer ľimpact de certains polymorphismes génétiques sur la variabilité de réponse aux analgésiques. Sources: Revue systématique par recherche informatisée structurée dans la base Medline (1966-2004), mots clés : pharmacogénétique ...
Dayer, Pierre +3 more
core
Influence of tobacco smoke on the pharmacokinetics of citalopram and its enantiomers [PDF]
, 2012 The purpose of this study was to evaluate the influence of tobacco smoke on the pharmacokinetics of citalopram (CIT) and desmethylcitalopram (DCIT) and its enantiomers on an animal model.
Florek, Ewa +5 more
core
Клинические аспекты функционирования системы цитохрома Р-450 микросом печени [PDF]
, 2005 В настоящем обзоре обобщены современные представления о системе цитохрома Р-450, роли в организме его важнейших изоформ, обсуждается вызванная лекарственными соединениями индукция либо ингибирование этой системы, приведены важные для клиники ...
Падалко, В.И. +1 more
core
Pharmacological interactions of anti-inflammatory-analgesics in odontology [PDF]
, 2009 In this second article we describe the more interesting pharmacological interactions in dental practice based on the prescription of analgesic narcotics, paracetamol and non-selective non-steroid anti-inflammatory drugs (NSAI) (which inhibit ...
Calvo Guirado, José Luis +3 more
core
Duloksetins betydning for serumkonsentrasjonen av psykofarmaka som omsettes via CYP2D6 [PDF]
, 2009 Bakgrunn: Duloksetin er et relativt nytt antidepressivum som hemmer reopptak av serotonin og noradrenalin intersynaptisk. Det metaboliseres via Cytokrom P450 2D6 (CYP2D6) og CYP1A2, men antas også å være en svak/moderat hemmer av CYP2D6.
Enoksen, Torill Bakko
core