Microscopy Research and Technique, Volume 88, Issue 8, Page 2321-2332, August 2025.This study investigated the effects of biosynthesized silver nanoparticles (AgNPs) derived from Hypericum perforatum on the cell morphology of Gram‐positive Staphylococcus aureus bacterial cells, with FE‐SEM analysis showing distinct morphological changes in AgNP‐treated S. aureus cells compared to the control group.
Canan Sevinc‐Sasmaz +3 more
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Mitochondria as Regulators of Nonapoptotic Cell Death in Cancer
MedComm, Volume 6, Issue 8, August 2025.Mitochondrial fission and fusion are key processes in maintaining cellular health. Fission is driven by proteins like, Fis‐1, which recruits DRP‐1, to facilitate the division of mitochondria. Fusion, however, is mediated by mitofusion 1(MFN1), mitofusion 2(MFN2), and optic atrophy 1 (OPA1), which work together to merge mitochondria, allowing functional
Saloni Malla +8 more
wiley +1 more source
Environmentally persistent free radicals lead to selective inhibition of CYP1 monooxygenase activities, and increased production of reactive oxygen species by reaction uncoupling. [PDF]
Front Public HealthConnick JP +4 more
europepmc +1 more source
Potential Kidney Risks Associated With Clinical Doses of Omeprazole: In Vivo and In Vitro Studies
Clinical and Experimental Pharmacology and Physiology, Volume 52, Issue 8, August 2025.Omeprazole decreases cell proliferation and viability by disrupting gene expression; thus, the long‐term use of omeprazole may increase inflammation and environmental susceptibility. These findings provide valuable insights for the clinical use of omeprazole, highlighting the need for careful consideration of its effects in the kidney.
Zibo Xiong +7 more
wiley +1 more source
Commiphora myrrha resin extract-modulated cytochrome P-450 2C9 enzyme expression in cultured Hep G2 cells is associated with resin extract-derived metabolites binding to Pregnane X receptor. [PDF]
BMC Complement Med TherAlsharidah A +11 more
europepmc +1 more source
Acta Physiologica, Volume 241, Issue 8, August 2025.ABSTRACT Aim Podocytes, highly specialized epithelial cells located in the glomerulus of the kidney, are essential to the filtration barrier that ensures separation of blood and urine. These cells exhibit a unique architecture, characterized by an intricate network of foot processes interconnected by slit diaphragms, which serve as a critical selective
Desiree Loreth +2 more
wiley +1 more source
Development and Characterization of pFluor50, a Fluorogenic-Based Kinetic Assay System for High-Throughput Inhibition Screening and Characterization of Time-Dependent Inhibition and Inhibition Type for Six Human CYPs. [PDF]
MoleculesShriwas P +8 more
europepmc +1 more source
Coronary Microvascular Dysfunction in Ischaemic Heart Disease: Lessons From Large Animal Models
Basic &Clinical Pharmacology &Toxicology, Volume 137, Issue 2, August 2025.ABSTRACT The coronary microvasculature is principally responsible for matching coronary blood flow to myocardial demand of oxygen and nutrients. Short‐term control of coronary blood flow is achieved via alterations in coronary microvascular tone, whereas long‐term control of coronary flow also involves remodelling of the coronary microvasculature ...
Oana Sorop +3 more
wiley +1 more source
A new naphthalene-based fluorogenic substrate for cytochrome P450 4A11. [PDF]
Biochem JDavydov DR +4 more
europepmc +1 more source
Drug Exposure in Chronic Kidney Disease: It Is Not Just About the Glomerular Filtration Rate
Fundamental &Clinical Pharmacology, Volume 39, Issue 4, August 2025.ABSTRACT Chronic kidney disease (CKD) affects over 10% of the world's population and is associated with high morbidity and mortality rates. The management of CKD is complex; CKD alters drug pharmacokinetics and pharmacodynamics and further complicates therapeutic strategies regimens.
Sophie Liabeuf +6 more
wiley +1 more source