Results 141 to 150 of about 104,306 (283)

FeDSNP‐Pa Nanoassemblies: A Triple‐Action Therapeutic Strategy Targeting Oxidative Stress, Inflammation, and Pyroptosis for Retinal Ganglion Cell Protection in Glaucoma

Advanced Functional Materials, Volume 36, Issue 11, 5 February 2026.
FeDSNP‐Pa, a metallized nanoparticle loaded with sodium pyruvate (Pa), exerts triple therapeutic effects by scavenging reactive oxygen species (ROS), suppressing inflammatory responses, and inhibiting pyroptosis signaling pathways. This multifunctional neuroprotective strategy protecting retinal ganglion cells (RGCs) from elevated intraocular pressure ...
Yukun Wu, Xue Li, Tong Wu, Dan Ji, Yugang Bai, Xuezhi Zhou   +5 more
wiley   +1 more source

Leucine‐Dependent SLC7A5–PGAM5 Interaction Promotes Advanced Atherosclerosis Through Hindering Mitochondrial Function of Macrophages

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Higher plasma leucine is associated with increased risk of new‐onset myocardial infarction. Leucine deprivation alleviates advanced atherosclerosis in mice. Tumor‐induced leucine deprivation reprograms macrophage metabolism and increases CD5Lhi macrophages in mouse plaques. Mechanistically, leucine deficiency reduced SLC7A5‐PGAM5 binding in macrophages,
Shan Zhong, Xueyu Wang, Qingsong Li, Siqi Wang, Bin Sun, Wenjun Ni, Gengyu Zhou, Fan Wang, Xianwei Xie, Cheng Jin, Gang Xu, Peng Zhao, Xiang Peng, Feiyuan Han, Xiangwen Xi, Yidan Wang, Juan Xu, Yue Wang, Xia Gu, Shuo Li, Jian Zhang, Shuijie Li, Jinwei Tian   +22 more
wiley   +1 more source

Emergence of Staphylococcus aureus Resistance to Antimicrobial Peptides Nisin, NZ2114 and Bacitracin Involves Multiple Phenotypic Changes

Animal Research and One Health, Volume 4, Issue 1, Page 82-93, February 2026.
The AMP‐induced mutant Staphylococcus aureus strain nzR showed increased resistance, five gene mutations, and decreased surface anion levels. AMPs affect the NDH‐2 protein encoded by ndh gene inhibiting the growth of S. aureus. The deletion of the ndh gene promotes the development of AMPs resistance.
Lingyu Xiao, Xingyuan Ma, Ping Tian, Lianbin Li, Zafir Muhammad, Xiaokun Wang, Xuemei Xue, Jinhe Xiao, Liangjun Zheng, F. A. El‐Gohary, Xin Zhao, Junning Pu, Huping Xue   +12 more
wiley   +1 more source

Serotonergic Neuromodulation of Natural Products Isoreserpine and Isoreserpiline in Adult Zebrafish: An in Silico and In Vivo Investigation

Chemistry &Biodiversity, Volume 23, Issue 2, February 2026.
ABSTRACT Anxiety is a multidimensional behavioral disorder widely studied in neuroscience due to the involvement of specific neural circuits. Although benzodiazepines are commonly used, their side effects drive the search for new therapeutic alternatives.
Nádia Aguiar Portela Pinheiro, Ivana Carneiro Romão, Amanda Maria Barros Alves, Sônia Maria Costa Siqueira, Jane Eire Silva Alencar de Menezes, Emmanuel Silva Marinho, Maria Kueirislene Amâncio Ferreira, Márcia Machado Marinho, Herbert de Sousa Magalhães, Andreia Ferreira de Castro Gomes, Otília Deusdênia Loiola Pessoa, Hélcio Silva dos Santos   +11 more
wiley   +1 more source

Chemical Profiling, In Silico and In Vitro Studies to Identify Potential CDK2 and mTOR Inhibitor From Selaginella inaequalifolia (Hook. & Grev.) Spring Ethanolic Extracts

Chemistry &Biodiversity, Volume 23, Issue 2, February 2026.
ABSTRACT The current study is aimed to reveal the phytoprofile of Selaginella inaequalifolia (Hook. & Grev.) Spring using GC–MS and predict the drug properties, toxicity, biological properties of S. inaequalifolia ethanolic extracts (SiEE) using in silico methods and in vitro toxicity assays, namely, MTT and BSLB assay.
Johnson Marimuthu Alias Antonysamy, Sivaraman Arumugam, Robin Charles Antony Arulraj, Anne Wincy Jacob Thomas, Henrique D. M. Coutinho   +4 more
wiley   +1 more source

Biochemical Responses of Anopheles spp. Larvae to a Novel Brazilian BR101 Bacillus thuringiensis var. israelensis Formulation: Oxidative Stress, Detoxification Enzymes, and Safety for Nontarget Notonectidae and Gerridae Aquatic Insects

Chemistry &Biodiversity, Volume 23, Issue 2, February 2026.
Bti BR101 exhibits strong larvicidal activity against Anopheles larvae spp., with dose‐dependent mortality and LC50 of 3.13 µg/mL. Bti increases ROS, lipid and protein oxidation, and activates antioxidant enzymes (SOD, CAT, GPx) and detoxification pathways (MFO and esterases), indicating moderate oxidative stress.
Izabel Cristina de Oliveira Bentes, Dayane Dantas Abensour, Maria Luiza Lima da Costa, Raquel Telles de Moreira Sampaio, Leticia Bernadete da Silva, Francisco Augusto da Silva Ferreira, Cláudia Patrícia da Silva Tavares, Hergen Vieira de Souza, Francisco de Assis Marque, Mário Antonio Navarro da Silva, Eduarda Andrade de Lima, Gislayne Trindade Vilas‐Boas, João Antonio Cyrino Zequi, André Correa de Oliveira, Rosemary Aparecida Roque   +14 more
wiley   +1 more source

Toward a More accurate, Evidence-Based Classification of CYP Inhibitors: A Critical Appraisal of Current Systems. [PDF]

Clin Pharmacol Ther
Backman JT.
europepmc   +1 more source

Biosynthesis of Silver Nanoparticles Using Black Pepper (Piper nigrum) Seed Extract and Evaluation of Their Cytotoxicity

Chemistry &Biodiversity, Volume 23, Issue 2, February 2026.
This study reports the green biosynthesis of piperine‐functionalized silver nanoparticles from Piper nigrum seed extract, followed by comprehensive physicochemical characterization and in vitro cytotoxic evaluation. The results confirm successful nanocomposite formation and demonstrate a marked enhancement of cytotoxic activity against gastric cancer ...
Nylton Ferreira Maciel, Gleice VasconcelosPereira do Lago, Glauce Vasconcelos da Silva Pereira, Ingryd Nayara de Farias Ramos, Aline Costa Bastos, Igor Alexandre Rocha Barreto, Nathiel Sarges Moraes, Marcos NazarenoLauné dos Santos, João Augusto Pereira da Rocha, Alencar Kolinski Machado, Waldomiro Gomes Paschoal Junior, Marcio Marcelo da Silva Pessoa, Maria de Nazaré Maciel Uesugi, André Salim Khayat, Jorddy Neves Cruz, José de ArimatéiaRodrigues do Rêgo, Maria Regina Sarkis Peixoto Joele, Davi do Socorro Barros Brasil   +17 more
wiley   +1 more source

Oxidizable amino acids around cytochrome P450 hemes. [PDF]

J Inorg Biochem
Winkler JR.
europepmc   +1 more source

Biocatalytic Synthesis of Diamondoid Diols by the Brown‐Rot Fungus Wolfiporia cocos

ChemBioChem, Volume 27, Issue 3, February 2026.
Wolfiporia cocos cultures were tested for CH‐oxidative activity using rigid diamondoid substrates. Adamantane derivatives gave typical diols similar to known chemical oxidations, while diamantane‐4‐ol showed unusual selectivity, forming rare 4,9‐ and 1,9‐diols.
Valeriia V. Nikitenkova, Aryna M. Sydorenko, Holger Zorn, Tatyana Zhuk   +3 more
wiley   +1 more source