Results 231 to 240 of about 104,306 (283)
Some of the next articles are maybe not open access.
Inhalation of Butanols: Changes in the Cytochrome P-450 Enzyme System
1985After inhalation of different butanol isomers for 3 days (2000 ppm) and 5 days (500 ppm), liver and kidney parameters of the microsomal cytochrome P-450 enzyme system were increased. sec-Butanol caused the highest increase in cytochrome P-450 concentration with a 47% rise in the kidneys (500 ppm for 5 days) and 33% in the liver (2000 ppm for 3 days). A
K, Aarstad, K, Zahlsen, O G, Nilsen
openaire +2 more sources
Analytica Chimica Acta, 1991
Abstract A number of staining techniques on Western blots were compared with respect to sensitivity, background staining and practical applicability. After electrophoresis of a rat microsomal preparation, followed by blotting and incubation of a primary antibody against a purified cytochrome P-450 fraction, enzyme-labelled second antibodies were used
Jansen, EHJM +3 more
openaire +3 more sources
Abstract A number of staining techniques on Western blots were compared with respect to sensitivity, background staining and practical applicability. After electrophoresis of a rat microsomal preparation, followed by blotting and incubation of a primary antibody against a purified cytochrome P-450 fraction, enzyme-labelled second antibodies were used
Jansen, EHJM +3 more
openaire +3 more sources
Journal of Organometallic Chemistry, 1976
Abstract The biological oxidation of several tributyltin derivatives, by a cytochrome P-450 dependent monooxygenase enzyme system with reduced nicotinamideadeninedinucleotidephosphate as the essential cofactor, produced carbon-hydroxylated compounds identified as α-, β-, γ- and δ-hydroxybutyldibutyltin derivatives.
Richard H. Fish +2 more
openaire +1 more source
Abstract The biological oxidation of several tributyltin derivatives, by a cytochrome P-450 dependent monooxygenase enzyme system with reduced nicotinamideadeninedinucleotidephosphate as the essential cofactor, produced carbon-hydroxylated compounds identified as α-, β-, γ- and δ-hydroxybutyldibutyltin derivatives.
Richard H. Fish +2 more
openaire +1 more source
Toxicology Letters, 1982
The N- and ring-hydroxylation of 2-acetylaminofluorene (AAF) are examined with a reconstituted cytochrome P-450 enzyme system from liver microsomal fractions from both control and 3-methylcholanthrene (MC)-pretreated mice. Partial purification of cytochrome P-450 fraction is achieved by bacterial protease treatment of microsomes followed by Triton X ...
P D, Lotlikar, T F, Wang
openaire +2 more sources
The N- and ring-hydroxylation of 2-acetylaminofluorene (AAF) are examined with a reconstituted cytochrome P-450 enzyme system from liver microsomal fractions from both control and 3-methylcholanthrene (MC)-pretreated mice. Partial purification of cytochrome P-450 fraction is achieved by bacterial protease treatment of microsomes followed by Triton X ...
P D, Lotlikar, T F, Wang
openaire +2 more sources
Enzyme, 1982
The rate of oxidative demethylation of ethylmorphine by preparations of microsomes from livers of male rats decreased following whole-body gamma-irradiation, reaching a minimum of 50% of the control value on the 5th or 6th day. The value of apparent Vmax changed markedly after irradiation when the Km value was unaltered. At the same time, the amount of
J M, Zajac, P, Bernard
openaire +2 more sources
The rate of oxidative demethylation of ethylmorphine by preparations of microsomes from livers of male rats decreased following whole-body gamma-irradiation, reaching a minimum of 50% of the control value on the 5th or 6th day. The value of apparent Vmax changed markedly after irradiation when the Km value was unaltered. At the same time, the amount of
J M, Zajac, P, Bernard
openaire +2 more sources
Chemosphere, 1994
Abstract The aim of the present study was to find a suitable wild-rodent to be used as terrestrial bioindicator. The wild mice were trapped at three sites around Vienna and at a fourth location in the countryside. Apodemus flavicollis , the yellow-necked mouse, was the most frequently captured mouse at all four sites.
Amrit Bhatia +4 more
openaire +1 more source
Abstract The aim of the present study was to find a suitable wild-rodent to be used as terrestrial bioindicator. The wild mice were trapped at three sites around Vienna and at a fourth location in the countryside. Apodemus flavicollis , the yellow-necked mouse, was the most frequently captured mouse at all four sites.
Amrit Bhatia +4 more
openaire +1 more source
Journal of Inorganic Biochemistry, 1989
Initial reaction rates of oxygen consumption and hydrogen peroxide formation in a cytochrome P-450 catalyzed reaction are practically independent of the nature of tertiary amines that were used as substrates. From the kinetic studies and the substrate conversion results that the amount of water formed in a side reaction is determined by the substrate ...
O, Ristau +3 more
openaire +2 more sources
Initial reaction rates of oxygen consumption and hydrogen peroxide formation in a cytochrome P-450 catalyzed reaction are practically independent of the nature of tertiary amines that were used as substrates. From the kinetic studies and the substrate conversion results that the amount of water formed in a side reaction is determined by the substrate ...
O, Ristau +3 more
openaire +2 more sources
Cancer research, 1983
The metabolism of the suspected carcinogen trichloroethylene (TCE) was studied in in vitro systems involving purified rat liver cytochrome P-450; rat, human, and mouse liver microsomes; rat lung microsomes; and isolated rat and mouse hepatocytes. The studies support the view that metabolism of TCE proceeds through formation of a complex with oxygenated
R E, Miller, F P, Guengerich
openaire +1 more source
The metabolism of the suspected carcinogen trichloroethylene (TCE) was studied in in vitro systems involving purified rat liver cytochrome P-450; rat, human, and mouse liver microsomes; rat lung microsomes; and isolated rat and mouse hepatocytes. The studies support the view that metabolism of TCE proceeds through formation of a complex with oxygenated
R E, Miller, F P, Guengerich
openaire +1 more source
Bulletin of Environmental Contamination and Toxicology, 1987
DDT, in very first step of its detoxication is either transformed to DDD by reductive dechlorination (Walker i969; Hassal 1973) or DDE by dehydrochlorination (Datta 1970). For further detoxication, these metabolites undergo a series of reactions which result in the elimination of DDA in urine (Peterson and Robison 1964; Datta 1970; Gold and Brunk 1982).
S S, Zaidi, B D, Banerjee
openaire +2 more sources
DDT, in very first step of its detoxication is either transformed to DDD by reductive dechlorination (Walker i969; Hassal 1973) or DDE by dehydrochlorination (Datta 1970). For further detoxication, these metabolites undergo a series of reactions which result in the elimination of DDA in urine (Peterson and Robison 1964; Datta 1970; Gold and Brunk 1982).
S S, Zaidi, B D, Banerjee
openaire +2 more sources
Cytochrome P-450 enzyme system inhibitors/tretinoin interaction
Reactions Weekly, 2022openaire +1 more source