Kinetic studies of the N-demethylation of ethylmorphine by a cytochrome P-450-dependent enzyme system in human liver microsomes [PDF]
Biochemical Journal, 1971 S S Thorgeirsson, D. S. Davies
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Fatal poisoning case involving drug interaction due to the inhibition of cytochrome P450 [PDF]
Vojnosanitetski Pregled, 2021 Introduction. Cytochrome P450 (CYP) enzymes are responsible for the metabolism of various drugs and chemicals. The forensic pathologist should consider not only pharmacodynamic interactions by multiple drugs but also the pharmacokinetic drug interactions
Kinoshita Hiroshi +6 more
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A child with Kawasaki disease and genetic warfarin sensitivity from CYP2C9 and VKORC1 gene variants [PDF]
Pediatric Emergency Medicine Journal, 2020 Kawasaki disease (KD) is a common febrile disease in East Asia. Because KD with coronary artery aneurysm (CAA) may predispose to thrombosis, children with KD-associated CAA may need anticoagulation in addition to aspirin.
Myeongseob Lee, Lucy Youngmin Eun
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CHANGE IN INTESTINAL FLORA AND ITS ASSOCIATION WITH LIVER CYP2E1 IN MICE WITH LIVER INJURY INDUCED BY HIGH-INTENSITY ATORVASTATIN [PDF]
精准医学杂志, 2023 Objective To investigate the change in intestinal flora and its association with liver CYP2E1 in mice with li-ver injury caused by high-intensity atorvastatin (ATO).
SONG Bingxue, SONG Yuqing, LIU Xin, YU Haichu, XIN Hui, LIANG Hui
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The Blind Spot of Pharmacology: A Scoping Review of Drug Metabolism in Prematurely Born Children
Frontiers in Pharmacology, 2022 The limit for possible survival after extremely preterm birth has steadily improved and consequently, more premature neonates with increasingly lower gestational age at birth now require care. This specialized care often include intensive pharmacological
Mette Louise Mørk +3 more
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Journal of Photochemistry and Photobiology, 2021 The conjugation of photosensitizer with a molecule specific to receptors over-expressed on cancer cells is a promising approach for improving tumor selectivity in photodynamic therapy (PDT).
Arpana Parihar, PhD +2 more
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Frontiers in Pharmacology, 2022 Paclitaxel is a prescribed anticancer drug used to treat various cancers. It is a substrate of cytochrome P-450 (CYP-450) enzymes. Despite its efficacy, paclitaxel has severe side effects.
Alinafe Magret Kapelemera +13 more
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Current Trends in Treatment for Acid-Dependent Diseases: Clinical Efficacy and Safety of Rabeprazole
Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2021 Aim. A comparative review of the rabeprazole properties vs. other PPIs, its efficacy and safety in treatment for aciddependent diseases.Key points. Rabeprazole provides a rapid proton pump blockade in parietal cells due to its high dissociation constant (
O. D. Lopina +2 more
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The role of biotransformation processes in mediating interactions between psychotropic drugs and natural products [PDF]
, 2020 Many patients are not aware that natural products such as fruit juices or plant infusions can cause significant interactions with several drugs, some of which can be dangerous, especially when the medical treatment is for neurological or psychiatric ...
Bacinschi, Nicolae +6 more
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