Reliably assessing the electronic structure of cytochrome P450 on today's classical computers and tomorrow's quantum computers [PDF]
, 2022 An accurate assessment of how quantum computers can be used for chemical simulation, especially their potential computational advantages, provides important context on how to deploy these future devices. In order to perform this assessment reliably, quantum resource estimates must be coupled with classical simulations attempting to answer relevant ...
arxiv +1 more source
Canadine synthase from Thalictrum tuberosum cell cultures catalyses the formation of the methylenedioxy bridge in berberine synthesis [PDF]
, 1994 An enzyme system catalysing the formation of the methylenedioxy bridge at ring A of (S)-canadine [ = (S)-tetrahydroberberine] from (S)-tetrahydrocolumbamine has been detected in microsomal preparations from different Ranunculaceae and Berberidaceae cell ...
Rüffer, Martina, Zenk, Meinhart H.
core +2 more sources
Recombinant mouse cytochromes P1-450 and P3-450: enzymatic characterization of the hemoprotein expressed in human cells infected with recombinant vaccinia virus. [PDF]
, 1993 We expressed mouse cytochrome P1-450 and P3-450 using recombinant vaccinia virus gene expression system in HeLa cells that were devoid of significant basal levels of P-450.
Battula, Narayama +4 more
core +1 more source
A Comparative Study of the Effects of Sesbania Drummondii on the Hepatic Cytochrome P-450 Monooxygenase Systems of Chickens and Rats. [PDF]
, 1990 The effect of an extract of Sesbania drummondii on the hepatic cytochrome P-450 monooxygenase system was evaluated in two experimental models, the White Leghorn chicken and the Sprague-Dawley rat.
Banton, Marcy Iva
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Kinetics of proton pumping in cytochrome c oxidase [PDF]
J. Chem. Phys. 130, 235105 (2009), 2008 We propose a simple model of cytochrome c oxidase, including four redox centers and four protonable sites, to study the time evolution of electrostatically coupled electron and proton transfers initiated by the injection of a single electron into the enzyme.
arxiv +1 more source
Hydroxylation of benzphetamine and other drugs by a solubilized form of cytochrome P-450 from liver microsomes: Lipid requirement for drug demethylation [PDF]
, 1969 A solubilized hepatic microsomal enzyme system previously shown to catalyze the [omega]-hydroxylation of fatty acids also catalyzes the hydroxylation of drugs. Benzphetamine, aminopyrine, ethylmorphine, hexobarbital, norcodeine, and -nitroanisole undergo
Coon, Minor J. +2 more
core +1 more source
Presence of cytochrome P-450-dependent monooxygenase in intimal cells of the hog aorta [PDF]
, 1985 Cytochrome P-450-dependent mixed function oxidase activity is present in vascular tissue; however, as far as we could determine, the distribution of monooxygenase activity across the blood vessel wall has not previously been assessed.
Abraham NG +4 more
core +1 more source
Radiometric assay for cytochrome P-450-catalyzed progesterone 16[alpha]-hydroxylation and determination of an apparent isotope effect [PDF]
, 1987 In the course of studies on the oxygenation of steroids by purified P-450 cytochromes, particularly rabbit liver microsomal cytochrome P-450 form 3b, a rapid and reliable radiometric assay has been devised for progesterone 16[alpha]-hydroxylation.
Bradlow +27 more
core +1 more source
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
, 2022 Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source
Bio‐Inspired Self‐Assembly of Enzyme‐Micelle Systems for Semi‐Artificial Photosynthesis
Angewandte Chemie, EarlyView.This study introduces a bio‐hybrid assembly inspired by lipid‐protein interactions in nature by utilizing photosensitized surfactants that self‐assemble into light‐absorbing micellar scaffolds capable of interfacing with hydrogenases and formate dehydrogenases. This semi‐artificial approach enabled benchmark turnover numbers for solar H2 production and
Yongpeng Liu +14 more
wiley +2 more sources