Results 21 to 30 of about 35,768 (229)

Current Trends in Treatment for Acid-Dependent Diseases: Clinical Efficacy and Safety of Rabeprazole

open access: yesРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии, 2021
Aim. A comparative review of the rabeprazole properties vs. other PPIs, its efficacy and safety in treatment for aciddependent diseases.Key points. Rabeprazole provides a rapid proton pump blockade in parietal cells due to its high dissociation constant (
O. D. Lopina   +2 more
doaj   +1 more source

The effect of variation of dose, time toward cauli flower (Brassica oleracea var BotrytisL.) On hepatic cytochrome P-450 level rats given theophylline

open access: yesIndonesian Journal of Pharmacy, 2011
Cytochrome P-450 as a major component enzyme system in drug metabolism. Activity enzyme of cytochrome P-450 was influenced by internal and external factors.
Endang Sri Sunarsih   +3 more
doaj   +1 more source

Effects of Epoxyeicosatrienoic Acid-Enhancing Therapy on the Course of Congestive Heart Failure in Angiotensin II-Dependent Rat Hypertension: From mRNA Analysis towards Functional In Vivo Evaluation

open access: yesBiomedicines, 2021
This study evaluates the effects of chronic treatment with EET-A, an orally active epoxyeicosatrienoic acid (EETs) analog, on the course of aorto-caval fistula (ACF)-induced heart failure (HF) in Ren-2 transgenic rats (TGR), a model characterized by ...
Petr Kala   +16 more
doaj   +1 more source

Comparison of clinical pharmacology of voriconazole and posaconazole

open access: yesContemporary Oncology, 2016
Despite greater knowledge and possibilities in pharmacotherapy, fungal infections remain a challenge for clinicians. As the population of immunocompromised patients and those treated for their hematologic ailments increases, the number of fungal ...
Beata M. Sienkiewicz   +2 more
doaj   +1 more source

Antioxidant Activity of New Aramide Nanoparticles Containing Redox-Active <em>N</em>-phthaloyl Valine Moieties in the Hepatic Cytochrome P<sub>450</sub> System in Male Rats

open access: yesMolecules, 2012
We report the synthesis of aramide nanoparticles containing a chiral <em>N</em>-phthaloyl valine moiety and their antioxidant activities on hepatic contents of cytochrome P<sub>450</sub>, amidopyrene <em>N</em> ...
Hammed H. A. M. Hassan   +3 more
doaj   +1 more source

Pharmacokinetics of Caffeine: A Systematic Analysis of Reported Data for Application in Metabolic Phenotyping and Liver Function Testing

open access: yesFrontiers in Pharmacology, 2022
Caffeine is by far the most ubiquitous psychostimulant worldwide found in tea, coffee, cocoa, energy drinks, and many other beverages and food. Caffeine is almost exclusively metabolized in the liver by the cytochrome P-450 enzyme system to the main ...
Jan Grzegorzewski   +3 more
doaj   +1 more source

Medicinal importance of grapefruit juice and its interaction with various drugs

open access: yesNutrition Journal, 2007
Grapefruit juice is consumed widely in today's health conscious world as a protector against cardiovascular diseases and cancers. It has however, been found to be an inhibitor of the intestinal cytochrome P – 450 3A4 system, which is responsible for the ...
Imam Sardar Z, Kiani Jawad
doaj   +1 more source

Drug-induced liver toxicity and prevention by herbal antioxidants: an overview

open access: yesFrontiers in Physiology, 2016
The liver is the center for drug and xenobiotic metabolism, which is influenced most with medication/xenobiotic-mediated toxic activity. Drug-induced hepatotoxicity is common and its actual frequency is hard to determine due to underreporting ...
Divya eSingh   +2 more
doaj   +1 more source

Cellular development associated with induced mycotoxin synthesis in the filamentous fungus Fusarium graminearum. [PDF]

open access: yesPLoS ONE, 2013
Several species of the filamentous fungus Fusarium colonize plants and produce toxic small molecules that contaminate agricultural products, rendering them unsuitable for consumption. Among the most destructive of these species is F.
Jon Menke   +3 more
doaj   +1 more source

Adrenal mitochondria and steroidogenesis: from individual proteins to functional protein assemblies

open access: yesFrontiers in Endocrinology, 2016
The adrenal cortex is critical for physiological function as the central site of glucocorticoid and mineralocorticoid synthesis. It possesses a great degree of specialized compartmentalization at multiple hierarchical levels, ranging from the tissue down
Andrew Midzak, Vassilios Papadopoulos
doaj   +1 more source

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