Microsomal cytochrome P-450: substrate binding, membrane interactions, and topology.
, 1989 The microsomal monoxygenase system is of paramount importance for the metabolism of endogenous substrates and xenobiotics. It is capable of detoxifying many compounds, but also activates procarcinogens to carcinogens.
Richter C, Winterhalter KH, Vergères G
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Characterization of a phenobarbital-inducible cytochrome P-450, NADPH-cytochrome P-450 reductase and reconstituted cytochrome P-450 mono-oxygenase system from rat brain. Evidence for constitutive presence in rat and human brain [PDF]
, 1992 Cytochrome P-450 was purified to apparent homogeneity from the brain microsomes of phenobarbital-treated rats. The specific content of the purified P-450 was 12.7 nmol/mg of protein.
Boyd, M. R. +2 more
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Alcohol metabolism and toxicity: Role of cytochrome P-450 [PDF]
, 1984 A new isozyme of cytochrome P-450, designated form 3a on the basis of its relative electrophoretic mobility, has been purified to homogeneity from liver microsomes of rabbits treated chronically with ethanol.
Koop, Dennis R. +3 more
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Severe combined adrenal and gonadal deficiency caused by novel mutations in the cholesterol side chain cleavage enzyme, P450scc [PDF]
, 2008 Context: Mitochondrial cytochrome P450scc converts cholesterol to pregnenolone in all steroidogenic tissues. Although progesterone production from the fetally-derived placenta is necessary to maintain pregnancy to term, four patients with mutations in ...
Huang, NW +6 more
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British Journal of Clinical Pharmacology, EarlyView.While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis +5 more
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A study of cytochrome P-450 from Saccharomyces cerevisiae.
, 1979 Yeast (Saccharomyces cerevisiae NCYC No. 240) will synthesise a cytochrome P-450, with the characteristic spectral peak at 450 nm, in reduced form in complex with carbon monoxide.
Gondal, Javed Anwar.
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An investigation of Cytochrome P450 function in human cell Lines for potential use in a bioartificial liver device [PDF]
, 2010 Bioartificial Liver Devices (BAL) could provide hepatic function in patients with liver failure awaiting transplantation or liver regeneration. Certain BALs use human hepatoblastoma-derived HepG2 cells that can perform many hepatocyte specific ...
Thomas, A.
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British Journal of Clinical Pharmacology, EarlyView.Introduction Warfarin therapy is the mainstay of anticoagulation treatment in South Africa and requires frequent INR monitoring due to interindividual patient variability. Time in therapeutic range (TTR) reflects the proportion of total treatment time during which INR values are within therapeutic range.
Masudah Paleker +3 more
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A biochemical and immunochemical study of ovine adrenal cytochrome P-450 reductase [PDF]
, 1992 Thesis (MSc)--Stellenbosch University, 1992.ENGLISH ABSTRACT: This study describes: (a) the isolation · of ovine adrenal cytochrome P-450 reductase, (b) the preparation of , antibodies against this enzyme and (c) comparitive immunochemical studies ...
Petersen, Carmen J.
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BMEMat, EarlyView.A near‐infrared (NIR) light‐activated “lock‐key” nanodevice is reported for spatiotemporally resolved detection of intratumoral L‐lactate. The system stays silent until deep‐penetrating NIR light remotely unlocks its function, allowing for precise sensing within tumors.
Siyu Pan +8 more
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