Results 61 to 70 of about 102,281 (237)
Cell Journal, 2015 Objective: Cytochrome P450 is one of the major drug metabolizing enzyme families and its role in metabolism of cancer drugs cannot be less emphasized. The association between single nucleotide polymorphisms (SNPs) in CYP1A1 and pathogenesis of chronic
Samyuktha Lakkireddy +5 more
doaj
PLoS ONE, 2017 High acrylamide (ACR) content in heat-processed carbohydrate-rich foods, as well as roasted products such as coffee, almonds etc., has been found to be as a risk factor for carcinogenicity and genotoxicity by The World Health Organization.
Duru Aras +4 more
doaj +1 more source
Enzyme Mimic Displaying Oscillatory Behavior. Oscillating Reduction of Manganese(III) Porphyrin in a Membrane-Bound Cytochrome P-450 Model System [PDF]
Journal of the American Chemical Society, 1995 Contains fulltext : 10134.pdf (Publisher’s version ) (Open Access)
Schenning, A.P.H.J +5 more
openaire +2 more sources
Advanced Science, EarlyView.This work introduces a multimodal multi‐OoC platform that overcomes current limitations in liver‐tumor interaction studies and prodrug screening. By integrating dynamic microfluidic circuits, electrochemical sensing, and mass analysis, this platform enables non‐invasive, longitudinal monitoring of drug metabolism and hepatotoxicity, offering a ...
Dan Wang +10 more
wiley +1 more source
Evidence That Cytochrome \u3cem\u3eb\u3csub\u3e5\u3c/sub\u3e\u3c/em\u3e Acts as a Redox Donor in CYP17A1 Mediated Androgen Synthesis [PDF]
, 2016 Cytochrome P450 17A1 (CYP17A1) is an important drug target for castration resistant prostate cancer. It is a bi-functional enzyme, catalyzing production of glucocorticoid precursors by hydroxylation of pregnene-nucleus, and androgen biosynthesis by a ...
Denisov, Ilia G. +5 more
core +1 more source
Annals of Neurology, EarlyView.Objective Cerebral ischemic stroke causes neuronal oxygen/energy deprivation, disrupting mitochondrial function including reduced membrane potential and bioenergetics, exacerbating neuronal injury. Mitochondrial defects are, therefore, a central neuropathological node and potential therapeutic target.
Ning Bian +9 more
wiley +1 more source
Model System Studies of Axial Ligation in the Oxidized Reaction States of Cytochrome P-450 Enzymes
, 1976 Cytochrome P-450 enzymes have been isolated from bacteria, microsomes, and mitochondria and catalyze the insertion of one atom of dioxygen into substrate while the other is reduced to water. The biological and many of the physical properties of these enzymes are summarized elsewhere (Hill et al., 1970a; Ullrich, 1972; Gunsalus et al., 1973; Tomaszewski
Holm, R. H. +6 more
openaire +3 more sources
Integrated Assessment of Lipid Oxidation and Off‐Flavor Formation in Plant Protein Powders
Journal of the American Oil Chemists' Society, EarlyView.Impact of residual lipids on oxylipin and off‐flavor formation in commercial plant proteins: A detailed analysis of precursor‐product relationships by GC‐FID, LC‐MS/MS, and GC‐MS. ABSTRACT The widespread adoption of plant proteins is hindered by their inherent off‐flavors, often linked to lipid oxidation products.
Fernanda Furlan Goncalves Dias +3 more
wiley +1 more source
Flavonoids and Furanocoumarins Involved in Drug Interactions
MoleculesDrug interactions can have significant consequences for public health, especially given the growing importance of readily available dietary supplements.
Sabine Berteina-Raboin
doaj +1 more source
Developmental toxicity of combined ethylbenzene and methylethylketone administered by inhalation to rats [PDF]
, 2006 Pregnant Sprague–Dawley rats were exposed to ethylbenzene (EB; 0, 250, or 1000 ppm) and methylethylketone (MEK; 0, 1000, or 3000 ppm), alone and in combination, by inhalation, for 6 h/day, during days 6–20 of gestation.
Bourges-Abella, Nathalie +6 more
core +1 more source