Results 91 to 100 of about 300,993 (238)
mBio, 2016 Ergosterol is a major and specific component of the fungal plasma membrane, and thus, the cytochrome P450 enzymes (Erg proteins) that catalyze ergosterol synthesis have been selected as valuable targets of azole antifungals.
Jinxing Song +7 more
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Acta Pharmaceutica Sinica B, 2012 Cytochrome P450 (CYP)-mediated epoxidation of arachidonic acid (AA) contributes to important biological functions, including the pain-relieving responses produced by analgesic drugs. However, the relevant epoxygenase(s) remain unidentified. Presently, we
Jun Yang +4 more
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Cytochrome P450-Activated Prodrugs [PDF]
Future Medicinal Chemistry, 2013 A prodrug is a compound that has negligible, or lower, activity against a specified pharmacological target than one of its major metabolites. Prodrugs can be used to improve drug delivery or pharmacokinetics, to decrease toxicity, or to target the drug to specific cells or tissues.
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Cytochrome P450 Dynamics [PDF]
, 2014 The unique P450 architecture is designed, in part, to enable the structure to adopt open and closed conformations. These changes are required to provide substrate access to the active site. Some of these motions also appear to be important in proton-coupled electron transfer associated with O2 activation.
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Signals for the incorporation and orientation of cytochrome P450 in the endoplasmic reticulum membrane. [PDF]
, 1988 S. Monier +4 more
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Porcine Cytochrome P450 and Metabolism [PDF]
Current Pharmaceutical Design, 2006 The pig and especially the minipig are becoming increasingly used as a test animal both in pharmacological and toxicological testing of new compounds. The minipig is used because of its size, it is easy to handle and less test substrate is required. When using an animal species for testing it is of importance to know if the test animal's posses the ...
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Effect of Mitochondrial Cytochromes and Haem Content on Cytochrome P450 in Saccharomyces cerevisiae [PDF]
, 1986 Franz Meußdoerffer, A. Fiechter
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Cytochromes P450: a success story.
Genome biology, 2000 Cytochrome P450 proteins, named for the absorption band at 450 nm of their carbon-monoxide-bound form, are one of the largest superfamilies of enzyme proteins. The P450 genes (also called CYP) are found in the genomes of virtually all organisms, but their number has exploded in plants.
Werck-Reichhart, D., Feyereisen, René
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Effect of hemochromatosis on hepatic cytochrome P450 and antipyrine metabolism in humans. [PDF]
, 1984 Herbert L. Bonkovsky +2 more
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The Effects of Phenobarbital or Cholic Acid on Hepatic Microsomal Cytochrome P450 and Hydroxylation of 2-AAF in Cholestatic Rats [PDF]
, 1981 B.H. Kim, Ye-Seon Hong, N.E. Sung
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