Results 131 to 140 of about 506,903 (380)

Cytochrome P450 Dynamics [PDF]

, 2014
The unique P450 architecture is designed, in part, to enable the structure to adopt open and closed conformations. These changes are required to provide substrate access to the active site. Some of these motions also appear to be important in proton-coupled electron transfer associated with O2 activation.
openaire   +2 more sources

Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy.

Journal of the American Medical Association (JAMA), 2009
CONTEXT Clopidogrel therapy improves cardiovascular outcomes in patients with acute coronary syndromes and following percutaneous coronary intervention by inhibiting adenosine diphosphate (ADP)-dependent platelet activation. However, nonresponsiveness is
A. Shuldiner, J. O’Connell, K. Bliden, A. Gandhi, K. Ryan, R. Horenstein, C. Damcott, R. Pakyz, U. Tantry, Q. Gibson, T. Pollin, W. Post, A. Parsa, B. Mitchell, N. Faraday, W. Herzog, P. Gurbel   +16 more
semanticscholar   +1 more source

Artificial intelligence modelling of tyrosine kinase inhibitors at risk of malabsorption and bioavailability‐enhancing strategies

British Journal of Clinical Pharmacology, EarlyView.
Aims The study aims to predict and improve the absorption of tyrosine kinase inhibitors (TKIs) in patients with malabsorption issues, particularly those who have undergone bariatric surgery or are using proton‐pump inhibitors. The research involves 2 main components: the development of an artificial intelligence (AI) model to identify TKIs that are ...
Daan W. Huntjens, Olivier J. M. Béquignon, Stefanie D. Krens, Mark Löwenberg, Martine E. D. Chamuleau, Remco J. Molenaar, Anita M. G. Kramers, Marianne A. Kuijvenhoven, Imke H. Bartelink   +8 more
wiley   +1 more source

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Cytochrome P450 2C24: expression, tissue distribution, high-throughput assay, and pharmacological inhibition

Acta Pharmaceutica Sinica B, 2012
Cytochrome P450 (CYP)-mediated epoxidation of arachidonic acid (AA) contributes to important biological functions, including the pain-relieving responses produced by analgesic drugs. However, the relevant epoxygenase(s) remain unidentified. Presently, we
Jun Yang, Melissa A. VanAlstine, James G. Phillips, Mark P. Wentland, Lindsay B. Hough   +4 more
doaj   +1 more source

Effect of Mitochondrial Cytochromes and Haem Content on Cytochrome P450 in Saccharomyces cerevisiae [PDF]

, 1986
Franz Meußdoerffer, A. Fiechter
openalex   +1 more source

A theoretical study on the acid‐catalyzed disproportionation reaction of a Mn(IV)‐oxo porphyrin complex

Bulletin of the Korean Chemical Society, EarlyView.
How do disproportionation reactions occur in high‐valent metal‐oxo species? We aim to describe the reaction mechanism of how a synthetic MnIVO‐porphyrin species disproportionates to a formal MnV and MnIII species, using density functional theory.
Steiny Russelisaac Premakumari, Yunhee Choi, Maggie Ng, Vandana Kardam, Wonwoo Nam, Kyung‐Bin Cho   +5 more
wiley   +1 more source

Comprehensive mRNA and microRNA analysis revealed the effect and response strategy of freshwater fish, grass carp (Ctenopharyngodon idella) under geosmin exposure

Ecotoxicology and Environmental Safety
Geosmin is an environmental pollutant that causes off-flavor in water and aquatic products. The high occurrence of geosmin contamination in aquatic systems and aquaculture raises public awareness, however, few studies have investigated the response ...
Jun-ming Zhang, Huan Han, Yi-chao Li, Bing Fu, Gen Kaneko, Kang Li, Xi-chen Jin, Shuang Ji, Er-meng Yu, Li-ping Liu   +9 more
doaj  

Signals for the incorporation and orientation of cytochrome P450 in the endoplasmic reticulum membrane. [PDF]

, 1988
S. Monier, P Van Luc, Gert Kreibich, David D. Sabatini, Milton Adesnik   +4 more
openalex   +1 more source

Porcine Cytochrome P450 and Metabolism [PDF]

Current Pharmaceutical Design, 2006
The pig and especially the minipig are becoming increasingly used as a test animal both in pharmacological and toxicological testing of new compounds. The minipig is used because of its size, it is easy to handle and less test substrate is required. When using an animal species for testing it is of importance to know if the test animal's posses the ...
openaire   +3 more sources