Results 131 to 140 of about 127,252 (263)

Tuning architectural organization of eukaryotic P450 system to boost bioproduction in Escherichia coli

Nature Communications
Eukaryotic cytochrome P450 enzymes, generally colocalizing with their redox partner cytochrome P450 reductase (CPR) on the cytoplasmic surface of organelle membranes, often perform poorly in prokaryotic cells, whether expressed with CPR as a tandem ...
Yikui Li, Jie Li, Wei-Kang Chen, Yang Li, Sheng Xu, Linwei Li, Bing Xia, Ren Wang   +7 more
doaj   +1 more source

Characterization of the Cubamyces menziesii terpenome

ChemBioChem, Accepted Article.
Long‐lasting polypore fungi are significant producers of terpene cyclases of high interest for medicinal or biotechnological applications. Following the 1,000 Fungal Genomes initiative launched by the Joint Genome Institute, we explored the genome of Cubamyces (C.) menziesii and identified eighteen genes encoding sesquiterpene cyclases. In a search for
Gilles Iacazio, Létitia Leydet, Julie Couillaud, Agnès Amouric, Elise Courvoisier-Dezort, Carole Avesque, Thierry Giardina, Mireille Attolini, Pierre Rousselot-Paillet, Katia Duquesne, Marie-Noelle Rosso   +10 more
wiley   +1 more source

Defining the Biologically Plausible Taxonomic Domain of Applicability of an Adverse Outcome Pathway: A Case Study Linking Nicotinic Acetylcholine Receptor Activation to Colony Death

Environmental Toxicology and Chemistry, Volume 42, Issue 1, Page 71-87, January 2023., 2023
Abstract For the majority of developed adverse outcome pathways (AOPs), the taxonomic domain of applicability (tDOA) is typically narrowly defined with a single or a handful of species. Defining the tDOA of an AOP is critical for use in regulatory decision‐making, particularly when considering protection of untested species.
Marissa A. Jensen, Donovan J. Blatz, Carlie A. LaLone   +2 more
wiley   +1 more source

Designing Enzymatic Reactivity with an Expanded Palette

ChemBioChem, EarlyView.
Innovation in biocatalysis is rapidly increasingly the diversity of catalytic reactivity that can be mediated by enzymes, addressing a key bottleneck for their widespread adoption in industrial chemical synthesis. A key approach to this is building enzymes with unnatural catalytic components that provide an expanded palette with new possibilities for ...
Reuben B. Leveson‐Gower
wiley   +1 more source

Pioneering Women Shaping the Field of Biocatalysis

ChemCatChem, EarlyView.
Groundbreaking works of women scientists in biocatalysis are highlighted in this article. Their innovative contributions are categorized in four interrelated research areas, collectively driving advancements in enzymatic biotransformations. Abstract In this perspective article, we celebrate the accomplishments of female‐led research groups in ...
Ana I. Benítez‐Mateos, Caroline E. Paul, Sandy Schmidt, Martina Letizia Contente   +3 more
wiley   +1 more source

Investigating electron conductivity regimes in the bacterial cytochrome wire OmcS [PDF]

arXiv
The anaerobic bacterium \textit{Geobacter sulfurreducens} produces extracellular, electronically conductive cytochrome polymer wires that are conductive over micron length scales. Structure models from cryo-electron microscopy data show OmcS wires form a linear chain of hemes along the protein wire axis, which is proposed as the structural basis ...
arxiv  

Translational Medicine in Alzheimer's Disease: The Journey of Donanemab From Discovery to Clinical Application

Chronic Diseases and Translational Medicine, EarlyView.
Donanemab, approved by the U.S. FDA in July 2024, targets amyloid plaques in the brain to treat Alzheimer's disease in patients with mild cognitive impairment or mild dementia. ABSTRACT Substantial research has been conducted to identify an efficient treatment for Alzheimer's disease (AD).
Nandhini Jayaprakash, Karthikeyan Elumalai   +1 more
wiley   +1 more source

Contemporary Perspectives on Chronic Renal Disorders

Chronic Diseases and Translational Medicine, EarlyView.
ABSTRACT The prevalence of renal diseases and its associated burden on healthcare have tremendously risen in the past few years. From simple markers assessing kidney function, current renal research delves into understanding the diseases at the cellular and molecular levels and not just at treating, but at improving quality of life, arresting ...
Deenadhayalan Ashok, Poornima Ajay Manjrekar, Bhushan C. Shetty, Sujina S. S, Rukmini Mysore Srikantiah, Sowndarya Kollampare   +5 more
wiley   +1 more source

Pharmaceutical removal from wastewater by introducing cytochrome P450s into microalgae

Microbial Biotechnology
Pharmaceuticals are of increasing environmental concern as they emerge and accumulate in surface‐ and groundwater systems around the world, endangering the overall health of aquatic ecosystems.
Thamali Kariyawasam, Christian Helvig, Martin Petkovich, Bas Vriens   +3 more
doaj   +1 more source

Faster quantum chemistry simulations on a quantum computer with improved tensor factorization and active volume compilation [PDF]

arXiv
Electronic structure calculations of molecular systems are among the most promising applications for fault-tolerant quantum computing (FTQC) in quantum chemistry and drug design. However, while recent algorithmic advancements such as qubitization and Tensor Hypercontraction (THC) have significantly reduced the complexity of such calculations, they do ...
arxiv