Angewandte Chemie International Edition, Volume 61, Issue 51, December 19, 2022., 2022 Corramycin is a novel natural product produced by the myxobacterium Corallococcus coralloides. The structure, extraordinary total synthesis and biosynthesis of the antibiotic is described for the first time. Its promise as an in vivo septicemia model, the absence of cross‐resistance with commonly used antibiotic classes, and the lack of cytotoxicity ...
Cédric Couturier +32 more
wiley +1 more source
Methods for determining Cytochrome P450 reductase in biological fluids of animals [PDF]
BIO Web of ConferencesThe study provides a literature review of modern methods for determining Cytochrome P450 reductase. The importance of the enzyme in the body is established.
Ponamarev Vladimir
doaj +1 more source
Cloning and Expression of Multiple Cytochrome P450 Genes: Induction by Fipronil in Workers of the Red Imported Fire Ant (Solenopsis invicta Buren). [PDF]
PLoS ONE, 2016 Both exogenous and endogenous compounds can induce the expression of cytochrome P450 genes. The insect cytochrome P450 genes related to insecticide resistance are likely to be expressed as the "first line of defense" when challenged with insecticides. In
Baizhong Zhang +4 more
doaj +1 more source
The Role of Cytochrome P450 AbyV in the Final Stages of Abyssomicin C Biosynthesis
Angewandte Chemie International Edition, Volume 62, Issue 3, January 16, 2023., 2023 The cytochrome P450 enzyme AbyV catalyses a key epoxidation in the final stages of the biosynthesis of the spirotetronate antibiotic abyssomicin C. Combining structural and computational data with a 13C labelling strategy was found to be a powerful approach to interrogate the biotransformation and determine the precise function of the enzyme.
Andrew J. Devine +13 more
wiley +1 more source
Mutations in
mBio, 2020 Candida auris has emerged as a multidrug-resistant pathogen of great clinical concern. Approximately 90% of clinical C. auris isolates are resistant to fluconazole, the most commonly prescribed antifungal agent, and yet it remains unknown what mechanisms
Jeffrey M. Rybak +12 more
doaj +1 more source
Defective Cytochrome P450-Catalysed Drug Metabolism in Niemann-Pick Type C Disease. [PDF]
PLoS ONE, 2016 Niemann-Pick type C (NPC) disease is a neurodegenerative lysosomal storage disease caused by mutations in either the NPC1 or NPC2 gene. NPC is characterised by storage of multiple lipids in the late endosomal/lysosomal compartment, resulting in cellular ...
Elena-Raluca Nicoli +16 more
doaj +1 more source
Cj1411c encodes for a cytochrome P450 involved in Campylobacter jejuni 81-176 pathogenicity. [PDF]
PLoS ONE, 2013 Cytochrome P450s are b-heme-containing enzymes that are able to introduce oxygen atoms into a wide variety of organic substrates. They are extremely widespread in nature having diverse functions at both biochemical and physiological level.
Luis A J Alvarez +6 more
doaj +1 more source
Identification and expression profile of the soil moisture and Ralstonia solanacearum response CYPome in ginger (Zingiber officinale) [PDF]
PeerJ, 2021 Background Cytochrome P450s play crucial roles in various biosynthetic reactions. Ginger (Zingiber officinale), which is often threatened by Ralstonia solanacearum, is the most economically important crop in the family Zingiberaceae.
Mengjun Huang +5 more
doaj +2 more sources
Fungal bioremediation of diuron-contaminated waters: evaluation of its degradation and the effect of amendable factors on its removal in a trickle-bed reactor under non-sterile conditions [PDF]
Science of The Total Environment Volume 743, 15 November 2020,
140628, 2020 The occurrence of the extensively used herbicide diuron in the environment poses a severe threat to the ecosystem and human health. Four different ligninolytic fungi were studied as biodegradation candidates for the removal of diuron. Among them, T. versicolor was the most effective species, degrading rapidly not only diuron (83%) but also the major ...
arxiv +1 more source