Methods for determining Cytochrome P450 reductase in biological fluids of animals [PDF]
BIO Web of ConferencesThe study provides a literature review of modern methods for determining Cytochrome P450 reductase. The importance of the enzyme in the body is established.
Ponamarev Vladimir
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Cloning and Expression of Multiple Cytochrome P450 Genes: Induction by Fipronil in Workers of the Red Imported Fire Ant (Solenopsis invicta Buren). [PDF]
PLoS ONE, 2016 Both exogenous and endogenous compounds can induce the expression of cytochrome P450 genes. The insect cytochrome P450 genes related to insecticide resistance are likely to be expressed as the "first line of defense" when challenged with insecticides. In
Baizhong Zhang +4 more
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Characterization of porcine hepatic and intestinal drug metabolizing CYP450 : comparison with human orthologues from a quantitative, activity and selectivity perspective [PDF]
, 2019 Over the past two decades, the pig has gained attention as a potential model for human drug metabolism. Cytochrome P450 enzymes (CYP450), a superfamily of biotransformation enzymes, are pivotal in drug metabolism.
Croubels, Siska +7 more
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The Use of Isomeric Testosterone Dimers to Explore Allosteric Effects in Substrate Binding to Cytochrome P450 CYP3A4 [PDF]
, 2016 : Cytochrome P450 CYP3A4 is the main drug-metabolizing enzyme in the human liver, being responsible for oxidation of 50% of all pharmaceuticals metabolized by human P450 enzymes.
Bastien, Dominic +6 more
core +2 more sources
Cytochromes P450 in Nanodiscs [PDF]
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2011 Nanodiscs have proven to be a versatile tool for the study all types of membrane proteins, including receptors, transporters, enzymes and viral antigens. The self-assembled Nanodisc system provides a robust and common means for rendering these targets soluble in aqueous media while providing a native like bilayer environment that maintains functional ...
Stephen G. Sligar, Ilia G. Denisov
openaire +3 more sources
Cytochrome P450 oxidoreductase participates in nitric oxide consumption by rat brain [PDF]
, 2009 In low nanomolar concentrations, NO (nitric oxide) functions as a transmitter in brain and other tissues, whereas near-micromolar NO concentrations are associated with toxicity and cell death.
Garthwaite, J., Hall, C.N., Keynes, R.G.
core +3 more sources
Mutations in
mBio, 2020 Candida auris has emerged as a multidrug-resistant pathogen of great clinical concern. Approximately 90% of clinical C. auris isolates are resistant to fluconazole, the most commonly prescribed antifungal agent, and yet it remains unknown what mechanisms
Jeffrey M. Rybak +12 more
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Defective Cytochrome P450-Catalysed Drug Metabolism in Niemann-Pick Type C Disease. [PDF]
PLoS ONE, 2016 Niemann-Pick type C (NPC) disease is a neurodegenerative lysosomal storage disease caused by mutations in either the NPC1 or NPC2 gene. NPC is characterised by storage of multiple lipids in the late endosomal/lysosomal compartment, resulting in cellular ...
Elena-Raluca Nicoli +16 more
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Engineering cytochrome P450 enzyme systems for biomedical and biotechnological applications
Journal of Biological Chemistry, 2019 Cytochrome P450 enzymes (P450s) are broadly distributed among living organisms and play crucial roles in natural product biosynthesis, degradation of xenobiotics, steroid biosynthesis, and drug metabolism.
Zhong Li +5 more
semanticscholar +1 more source
Mechanisms of Cytochrome P450-Catalyzed Oxidations.
ACS Catalysis, 2018 Enzymes are complex biological catalysts and are critical to life. Most oxidations of chemicals are catalyzed by cytochrome P450 (P450, CYP) enzymes, which generally utilize mixed-function oxidase stoichiometry, utilizing pyridine nucleotides as electron
F. Guengerich
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