Defective Cytochrome P450-Catalysed Drug Metabolism in Niemann-Pick Type C Disease. [PDF]
PLoS ONE, 2016 Niemann-Pick type C (NPC) disease is a neurodegenerative lysosomal storage disease caused by mutations in either the NPC1 or NPC2 gene. NPC is characterised by storage of multiple lipids in the late endosomal/lysosomal compartment, resulting in cellular ...
Elena-Raluca Nicoli +16 more
doaj +1 more source
Structure-Guided Recombination Creates an Artificial Family of Cytochromes P450 [PDF]
, 2006 Creating artificial protein families affords new opportunities to explore the determinants of structure and biological function free from many of the constraints of natural selection.
Arnold, Frances H. +5 more
core +1 more source
Resonance Raman Spectroscopy Reveals that Substrate Structure Selectively Impacts the Heme-Bound Diatomic Ligands of CYP17 [PDF]
, 2013 An important function of steroidogenic cytochromes P450 is the transformation of cholesterol to produce androgens, estrogens, and the corticosteroids.
Gregory, Michael C. +3 more
core +2 more sources
CYTOCHROME P450 ENZYMES AND PSYCHOTROPIC DRUGS
Psychiatry and Clinical Psychopharmacology, 2021 The discovery of the importance of cytochrome P450 enzymes in drug metabolism has been very recently.The information about the diversity,specificity and interindividual variation o f cytochrome P450 enzymes is increasing rapidly.
Nesrin Karamustafalıoğlu +2 more
doaj
Cytochrome P450 flexibility [PDF]
Proceedings of the National Academy of Sciences, 2003 Cytochrome P450 refers to a group of enzymes that catalyze the monooxygenation of various organic molecules in the following reaction: \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \setlength{\oddsidemargin}{-69pt} \begin{document} \begin ...
openaire +2 more sources
P450BM3-Catalyzed Oxidations Employing Dual Functional Small Molecules [PDF]
, 2019 A set of dual functional small molecules (DFSMs) containing different amino acids has been synthesized and employed together with three different variants of the cytochrome P450 monooxygenase P450BM3 from Bacillus megaterium in H2O2-dependent oxidation
Girhard, Marco +5 more
core +1 more source
Cj1411c encodes for a cytochrome P450 involved in Campylobacter jejuni 81-176 pathogenicity. [PDF]
PLoS ONE, 2013 Cytochrome P450s are b-heme-containing enzymes that are able to introduce oxygen atoms into a wide variety of organic substrates. They are extremely widespread in nature having diverse functions at both biochemical and physiological level.
Luis A J Alvarez +6 more
doaj +1 more source
The role of nicotinamide-β-adenine dinucleotide phosphate-H-cytochrome P450 oxidoreductase in the activation of cytochromes [PDF]
BIO Web of ConferencesThe aim of this theoretical study is to investigate the mechanisms of action of these enzymes in the context of metabolism in highly productive animals.
Popova Olga +3 more
doaj +1 more source
Journal of Lipid Research, 2000 The demonstration of in vivo arachidonic acid epoxidation and ω-hydroxylation established the cytochrome P450 epoxygenase and ω/ω–1 hydroxylase as formal metabolic pathways and as members of the arachidonate metabolic cascade. The characterization of the
Jorge H. Capdevila +2 more
doaj +1 more source
Identification and expression profile of the soil moisture and Ralstonia solanacearum response CYPome in ginger (Zingiber officinale) [PDF]
PeerJ, 2021 Background Cytochrome P450s play crucial roles in various biosynthetic reactions. Ginger (Zingiber officinale), which is often threatened by Ralstonia solanacearum, is the most economically important crop in the family Zingiberaceae.
Mengjun Huang +5 more
doaj +2 more sources