Results 41 to 50 of about 506,903 (380)

Resonance Raman Spectroscopy Reveals that Substrate Structure Selectively Impacts the Heme-Bound Diatomic Ligands of CYP17 [PDF]

, 2013
An important function of steroidogenic cytochromes P450 is the transformation of cholesterol to produce androgens, estrogens, and the corticosteroids.
Gregory, Michael C., Kincaid, James R., Mak, Piotr J., Sligar, Stephen G.   +3 more
core   +2 more sources

Cytochrome P450 research and The Journal of Biological Chemistry

Journal of Biological Chemistry, 2019
In honor of the 100th birthday of Dr. Herbert Tabor, JBC's Editor-in-Chief for 40 years, I will review here JBC's extensive coverage of the field of cytochrome P450 (P450) research.
X. F. P. Guengerich, R. Banerjee
semanticscholar   +1 more source

Impaired hepatic drug and steroid metabolism in congenital adrenal hyperplasia due to P450 oxidoreductase deficiency [PDF]

, 2010
Objective: Patients with congenital adrenal hyperplasia due to P450 oxidoreductase (POR) deficiency(ORD) present with disordered sex development and glucocorticoid deficiency.
Arlt, Bebia, Chang, de Morais, Dominique Maiter, Dorota Tomalik-Scharte, Fl  ck, Fuhr, Gomes, Hannah E Ivison, Henderson, Jetter, Julia Kirchheiner, Kelley, Kirchheiner, Kranendonk, Nebert, Nicolo, Parkinson, Porter, Ribes, Sachse, Tantcheva-Po  r, Tomalik-Scharte, Uwe Fuhr, Wiebke Arlt   +25 more
core   +2 more sources

On the occurrence of cytochrome P450 in viruses

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Cytochrome P450 monooxygenase enzymes metabolize drugs, carcinogens, and endogenous molecules in the Eukarya, the Bacteria, and the Archaea.
D. Lamb, A. Follmer, J. Goldstone, D. Nelson, A. Warrilow, Claire L Price, Marie Y True, S. Kelly, T. Poulos, J. Stegeman   +9 more
semanticscholar   +1 more source

The Pharmacogene Variation (PharmVar) Consortium: Incorporation of the Human Cytochrome P450 (CYP) Allele Nomenclature Database

Clinical pharmacology and therapy, 2017
The Human Cytochrome P450 (CYP) Allele Nomenclature Database, a critical resource for the pharmacogenetics and genomics communities, has transitioned to the Pharmacogene Variation (PharmVar) Consortium.
A. Gaedigk, M. Ingelman-Sundberg, Neil A. Miller, J. Leeder, Michelle Whirl‐Carrillo, T. Klein   +5 more
semanticscholar   +1 more source

The Role of procollagen type 1 amino-terminal propertied (P1NP) Cytochrome P450 (CYPs) and Osteoprotegerin (OPG) as Potential Bone function markers in Prostate Cancer Bone Metastasis

Romanian Journal of Laboratory Medicine, 2023
Background: Procollagen type I amino-terminal propeptide (PINP) is often present during osteoblast development and could be a biomarker of early bone development. Osteoprotegerin (OPG) may protect tumor cells from apoptosis.
Yousif Pshtiwan A., Ismail Parween Abdulsamad   +1 more
doaj   +1 more source

Functional characterization of the cytochrome P450 monooxygenase CYP71AU87 indicates a role in marrubiin biosynthesis in the medicinal plant Marrubium vulgare. [PDF]

, 2019
BackgroundHorehound (Marrubium vulgare) is a medicinal plant whose signature bioactive compounds, marrubiin and related furanoid diterpenoid lactones, have potential applications for the treatment of cardiovascular diseases and type II diabetes.
Addison, J Bennett, Dhanota, Puja, Fiehn, Oliver, Karunanithi, Prema S, Tong, Shen, Zerbe, Philipp   +5 more
core   +6 more sources

Association of Impaired Cytochrome P450 2D6 Activity Genotype and Phenotype With Therapeutic Efficacy of Primaquine Treatment for Latent Plasmodium vivax Malaria

JAMA Network Open, 2018
Key Points Question How is natural variation in cytochrome P450 2D6 activity associated with therapeutic efficacy of primaquine phosphate against latent Plasmodium vivax malaria?
J. Baird, M. Louisa, Rintis Noviyanti, L. Ekawati, I. Elyazar, Decy Subekti, Krisin Chand, Anggi Gayatri, Instiaty, S. Soebianto, Chelzie Crenna-Darusallam, D. Djoko, Bambang Dwi Hasto, Dubel Meriyenes, D. Wesche, E. Nelwan, I. Sutanto, H. Sudoyo, R. Setiabudy   +18 more
semanticscholar   +1 more source

Expression of steroidogenic enzymes and metabolism of steroids in COS-7 cells known as non-steroidogenic cells

Scientific Reports, 2018
The COS-7 (CV-1 in Origin with SV40 genes) cells are known as non-steroidogenic cells because they are derived from kidney cells and the kidney is defined as a non-steroidogenic organ.
Mitsuki Nozaki, Shogo Haraguchi, Takuro Miyazaki, Daichi Shigeta, Noriko Kano, Xiao-Feng Lei, Joo-ri Kim-Kaneyama, Hiroyuki Minakata, Akira Miyazaki, Kazuyoshi Tsutsui   +9 more
doaj   +1 more source

HETEROLOGOUS EXPRESSION OF RECOMBINANT MOUSE CYTOCHROME P450 2E1 IN ESCHERICHIA COLI

Mìkrobìologìâ ì Bìotehnologìâ. Мікробіологія і біотехнологія, 2012
Aim. The cloning of the mouse cytochrome P450 2E1 cDNA and obtaining of expression of cloned cDNA in E. coli. Methods. Polymerase chain reaction, cloning techniques, electrophoresis, Western blot. Results.
В. Н. Заец, В. О. Китам, В. В. Рущак, О. В. Максимчук, Н. А. Чащин   +4 more
doaj   +1 more source