Results 41 to 50 of about 127,252 (263)
Molecules, 2023 Osteoarthritis is one of the leading conditions that promote the consumption of these dietary supplements. Chondroitin sulfate, glucosamine, and methylsulfonylmethane are among the prominent alternative treatments for osteoarthritis. In this study, these
Su Min Kim +5 more
doaj +1 more source
Pharmacogenetics and Genomics, 2009 The cytochrome P450 2D6 (CYP2D6) is an enzyme of great historical importance for pharmacogenetics and is now thought to be involved in the metabolism of up to 25% of the drugs that are in common use in the clinic [1]. Several years before the gene was cloned, researchers observed that Caucasian population responded in a bimodal pattern to certain drugs
Russ B. Altman +3 more
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Cytochrome P450 2S1 is Reduced by NADPH-Cytochrome P450 Reductase [PDF]
Drug Metabolism and Disposition, 2011 Cytochrome P450 (P450) 2S1 is one of the orphan P450s without a clear physiological function. Controversy has arisen as to whether it can interact with NADPH-P450 reductase and accept electrons. The reduction of 1,4-bis{[2-(dimethylamino-N-oxide)ethyl]amino}-5,8-dihydroxyanthracene-9,10-dione (AQ4N) by P450 2S1 was confirmed, and the NADPH consumption ...
F. Peter Guengerich +2 more
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Gene family amplification facilitates adaptation in freshwater Unionid bivalve Megalonaias nervosa [PDF]
, 2020 As organisms are faced with intense rapidly changing selective pressures, new genetic material is required to facilitate adaptation. Among sources of genetic novelty, gene duplications and transposable elements (TEs) offer new genes or new regulatory patterns that can facilitate evolutionary change.
arxiv +1 more source
Annals of Clinical Microbiology and Antimicrobials, 2008 Introduction People infected with human immunodeficiency virus are frequently treated with medications that can induce or inhibit cytochrome P450 enzymes.
Horne Anne M +3 more
doaj +1 more source
Cytochrome P450 flexibility [PDF]
Proceedings of the National Academy of Sciences, 2003 Cytochrome P450 refers to a group of enzymes that catalyze the monooxygenation of various organic molecules in the following reaction: \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \setlength{\oddsidemargin}{-69pt} \begin{document} \begin ...
openaire +3 more sources
Molecular Oncology, EarlyView.Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley +1 more source
Microbial Cell Factories, 2020 Background Caffeic acid is industrially recognized for its antioxidant activity and therefore its potential to be used as an anti-inflammatory, anticancer, antiviral, antidiabetic and antidepressive agent.
Kristina Haslinger +1 more
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Journal of Plant Interactions, 2021 Cytochrome P450 genes are involved in the catalysis of various reactions, including growth, development and secondary metabolite biosynthetic pathways.
Shu Zhang +4 more
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Mediation with External Summary Statistic Information (MESSI) [PDF]
arXiv, 2023 Environmental health studies are increasingly measuring endogenous omics data ($\boldsymbol{M}$) to study intermediary biological pathways by which an exogenous exposure ($\boldsymbol{A}$) affects a health outcome ($\boldsymbol{Y}$), given confounders ($\boldsymbol{C}$). Mediation analysis is frequently carried out to understand such mechanisms.
arxiv