Results 51 to 60 of about 127,252 (263)

TOF-SIMS structural characterization of self-assembly monolayer of cytochrome b5 onto gold substrate [PDF]

Applied Surface Science 255 (2008) 1071-74, 2010
Orientation and three-dimensional structure of immobilized proteins on bio-devices are very important to assure their high performance. Time-of-flight secondary ion mass spectrometry (TOF-SIMS) is able to analyze upper surface of one layer of molecules.
arxiv   +1 more source

Murine Models and Human Cell Line Models to Study Altered Dynamics of Ovarian Follicles in Polycystic Ovary Syndrome

Advanced Biology, EarlyView.
The manuscript examines preclinical murine and human models to study polycystic ovary syndrome (PCOS), delving into the cellular and molecular mechanisms underlying altered ovarian follicular dynamics. It explores the cellular interactions involved in normal and PCOS ovaries and outlines the current and novel strategies in the search for preclinical ...
Arturo Bevilacqua, Cristiano Giuliani, Giovanna Di Emidio, Samuel H Myers, Vittorio Unfer, Carla Tatone   +5 more
wiley   +1 more source

COVID‐19 and myasthenia gravis: A review of neurological implications of the SARS‐COV‐2

Brain and Behavior, Volume 12, Issue 12, December 2022., 2022
Abstract Introduction This review highlights the potential mechanisms of neuromuscular manifestation of COVID‐19, especially myasthenia gravis (MG). Methods An extensive literature search was conducted by two independent investigators using PubMed/MEDLINE and Google Scholar from its inception to December 2020. Results Exacerbations of clinical symptoms
Syed Muhammad Ismail Shah, Farah Yasmin, Roha Saeed Memon, Nadia Nazir Jatoi, Ilma Saleh Savul, Sana Kazmi, Syed Abdullah Monawwer, Muhammad Daim Bin Zafar, Muhammad Sohaib Asghar, Muhammad Junaid Tahir, Ka Yiu Lee   +10 more
wiley   +1 more source

The Regulation of Trace Metal Elements in Cancer Ferroptosis

Advanced Biology, EarlyView.
The induction of ferroptosis inhibits tumor growth, enhances anticancer efficacy, and overcomes drug resistance. Recent evidence shows nonferrous metal elements play a role in ferroptosis. This review focuses on how trace metals regulate ferroptosis processes like iron accumulation, lipid peroxidation, and antioxidant defense.
Xiaoyan Wang, Yuanyuan Xue, Lei Chang, Xuena Zhu, Wenjun Liu, Tingbo Liang   +5 more
wiley   +1 more source

Gromomycins: An Unprecedented Class of Triterpene Antibiotics Produced by a Novel Biosynthetic Pathway

Angewandte Chemie, EarlyView.
Gromomycins represent a novel class of pentacyclic triterpene antibiotics with a unique biosynthetic pathway independent of the squalene route. These compounds exhibit potent activity against drug‐resistant Gram‐positive pathogens, including MRSA, and their unprecedented cyclization mechanism provides new insight into bacterial triterpene biosynthesis.
Stepan Tistechok, Dmytro Bratiichuk, Hilda Sucipto, Nils Gummerlich, Marc Stierhof, Oleksandr Gromyko, Franziska Fries, Victor Fedorenko, Rolf Müller, Josef Zapp, Maksym Myronovskyi, Andriy Luzhetskyy   +11 more
wiley   +2 more sources

Cytochrome P450 monooxygenases

Current Opinion in Chemical Biology, 1998
The field of P450 research is progressing rapidly. The active sites of structurally characterized bacterial P450 enzymes have been rationally re-engineered to alter both substrate specificity and selectivity of substrate oxidation. Many human P450 enzymes have been functionally expressed and new methods of substrate turnover described.
openaire   +3 more sources

Cell Membrane Vesicle Camouflaged Artificial Cells

Advanced Functional Materials, EarlyView.
Artificial cells camouflaged with a cell membrane vesicle coating are able to assemble into synthetic aggregates that exhibit rudimentary communication capabilities. Additionally, when these artificial cells are equipped with antioxidant capabilities, they are able to protect the intracellular homeostasis in HepG2 cells present in semi‐synthetic ...
Paula De Dios Andres, Stefan Pendlmayr, Noga Gal, Cathrine Abild Meyer, Cecilie Ryberg, Olav Vestrheim, Noel Angelo Kalacas, Fatih Demir, Markus M. Rinschen, Karsten Haupt, Rajeshwar Prosad Mookerjee, Brigitte Städler   +11 more
wiley   +1 more source

Isotope Techniques in Chemical Wastewater Treatment: Opportunities and Uncertainties

Angewandte Chemie, EarlyView.
In this review, we would first introduce basic knowledge about isotopic compounds and then scrutinize the physical and chemical influence induced by isotope changes. Special attention will be paid to the uncertainties in explaining the isotope results.
Hongyu Zhou, Xiaoguang Duan, Bingkun Huang, Shuang Zhong, Cheng Cheng, Virender K. Sharma, Shaobin Wang, Bo Lai   +7 more
wiley   +2 more sources

Could Cytochrome P450 2D6, 3A4 and 3A5 Polymorphisms Explain the Variability in Clinical Response to Clomiphene Citrate of Anovulatory PCOS Women?

Frontiers in Endocrinology, 2021
IntroductionCytochrome P450 2D6, 3A4 and 3A5 are involved in the metabolism of many drugs. These enzymes have a genetic polymorphism responsible for different metabolic phenotypes.
Camille Robin, Benjamin Hennart, Franck Broly, Philippine Gruchala, Geoffroy Robin, Geoffroy Robin, Sophie Catteau-Jonard, Sophie Catteau-Jonard   +7 more
doaj   +1 more source

Development of Photo‐Biocatalytic Redox System for Asymmetric Synthesis of Optically Active Amines Using Blue Light and Transaminases. A Case Study Toward Mavacamten

Advanced Synthesis &Catalysis, EarlyView.
Abstract α‐Chiral amines are versatile building blocks for the asymmetric synthesis of optically pure high‐added‐value chemicals, including pharmaceuticals, agrochemicals, and natural products. Herein, we report a one‐pot, two‐step sequential deracemization of racemic sec‐alcohols to optically enriched primary amines throught a photo‐biocatalytic ...
Natalia Antos, Aleksandra Rudzka, Anna Hoser, Tamara Reiter, Wolfgang Kroutil, Paweł Borowiecki   +5 more
wiley   +1 more source