Results 31 to 40 of about 101,816 (333)
QNA-Based Prediction of Sites of Metabolism
Molecules, 2017 Metabolism of xenobiotics (Greek xenos: exogenous substances) plays an essential role in the prediction of biological activity and testing for the subsequent research and development of new drug candidates.
Olga Tarasova +5 more
doaj +1 more source
Toxicomicrobiomics: The Human Microbiome vs. Pharmaceutical, Dietary, and Environmental Xenobiotics
Frontiers in Pharmacology, 2020 The harmful impact of xenobiotics on the environment and human health is being more widely recognized; yet, inter- and intraindividual genetic variations among humans modulate the extent of harm, mostly through modulating the outcome of xenobiotic ...
Nehal Adel Abdelsalam +5 more
doaj +1 more source
Frontiers in Molecular Biosciences, 2023 Dendroctonus-bark beetles are natural components and key ecological agents of coniferous forests. They spend most of their lives under the bark, where they are exposed to highly toxic terpenes present in the oleoresin.
J. Manuel Quijano-Barraza +5 more
doaj +1 more source
Kinetics of proton pumping in cytochrome c oxidase [PDF]
J. Chem. Phys. 130, 235105 (2009), 2008 We propose a simple model of cytochrome c oxidase, including four redox centers and four protonable sites, to study the time evolution of electrostatically coupled electron and proton transfers initiated by the injection of a single electron into the enzyme.
arxiv +1 more source
Data, 2018 Poppies are well-known plants in the family Papaveraceae that are rich in alkaloids. This family contains 61 species, and in this study we sequenced the transcriptomes of four species’ (Papaver rhoeas, Papaver nudicaule, Papaver fauriei, and ...
Dowan Kim +7 more
doaj +1 more source
Frontiers in Microbiology, 2020 Bacteria in the genus Geobacter thrive in iron- and manganese-rich environments where the divalent cobalt cation (CoII) accumulates to potentially toxic concentrations.
Hunter Dulay +3 more
doaj +1 more source
Catching proteins in liquid helium droplets [PDF]
Phys. Rev. Lett. 105, 133402 (2010), 2010 An experimental approach is presented that allows for the incorporation of large mass/charge selected ions in liquid helium droplets. It is demonstrated that droplets can be efficiently doped with a mass/charge selected amino acid as well as with the much bigger m$\approx$12 000 amu protein Cytochrome C in selected charge states.
arxiv +1 more source
The Small RNA RyhB Is a Regulator of Cytochrome Expression in Shewanella oneidensis
Frontiers in Microbiology, 2018 Shewanella oneidensis produces an extensive electron transfer network that results in metabolic flexibility. A large number of c-type cytochromes are expressed by S.
Karin L. Meibom +2 more
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Targeting cytochrome C oxidase in mitochondria with Pt(II)-porphyrins for Photodynamic Therapy [PDF]
, 2010 Mitochondria are the power house of living cells, where the synthesis of the chemical "energy currency" adenosine triphosphate (ATP) occurs. Oxidative phosphorylation by a series of membrane protein complexes I to IV, that is, the electron transport chain, is the source of the electrochemical potential difference or proton motive force (PMF) of protons
arxiv +1 more source
Portosystemic hepatic encephalopathy model shows reversal learning impairment and dysfunction of neural activity in the prefrontal cortex and regions involved in motivated behavior [PDF]
Journal of Clinical Neuroscience (2011)18(5):690-4, 2011 Hepatic encephalopathy is a neurological complication that affects attention and memory. Experimental animal models have been used to study hepatic Encephalopathy, the most frequent being the portacaval shunt. In order to determine learning impairment and brain functional alterations in this model, we assessed reversal learning and neural metabolic ...
arxiv +1 more source