Results 31 to 40 of about 102,161 (305)

Adherence to endocrine therapy with tamoxifen and satisfaction with follow-up of women with breast cancer by a gynecologist: A survey study [PDF]

Гинекология
Background. Side effects of endocrine therapy with tamoxifen (TAM) reduce the quality of life of patients with breast cancer (BC) and adversely affect treatment compliance.
Ekaterina O. Golubenko, Marina I. Savelyeva, Vera V. Korennaya   +2 more
doaj   +1 more source

QNA-Based Prediction of Sites of Metabolism

Molecules, 2017
Metabolism of xenobiotics (Greek xenos: exogenous substances) plays an essential role in the prediction of biological activity and testing for the subsequent research and development of new drug candidates.
Olga Tarasova, Anastassia Rudik, Alexander Dmitriev, Alexey Lagunin, Dmitry Filimonov, Vladimir Poroikov   +5 more
doaj   +1 more source

Divergent Cytochrome c Maturation System in Kinetoplastid Protists

mBio, 2021
Cytochromes ...
Asma Belbelazi, Rachel Neish, Martin Carr, Jeremy C. Mottram, Michael L. Ginger   +4 more
doaj   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Novel Extracellular Electron Transfer Channels in a Gram-Positive Thermophilic Bacterium

Frontiers in Microbiology, 2021
Biogenic transformation of Fe minerals, associated with extracellular electron transfer (EET), allows microorganisms to exploit high-potential refractory electron acceptors for energy generation.
Sergey N. Gavrilov, Daria G. Zavarzina, Ivan M. Elizarov, Tamara V. Tikhonova, Natalia I. Dergousova, Vladimir O. Popov, Vladimir O. Popov, Jonathan R. Lloyd, David Knight, Mohamed Y. El-Naggar, Sahand Pirbadian, Kar Man Leung, Frank T. Robb, Maksim V. Zakhartsev, Orianna Bretschger, Elizaveta A. Bonch-Osmolovskaya, Elizaveta A. Bonch-Osmolovskaya   +16 more
doaj   +1 more source

Cytochrome c binding affects the conformation of cytochrome a in cytochrome c oxidase.

Journal of Biological Chemistry, 1992
Second derivative absorption spectroscopy has been used to assess the effects of complex formation between cytochrome c and cytochrome c oxidase on the conformation of the cytochrome a cofactor. When ferrocytochrome c is complexed to the cyanide-inhibited reduced or mixed valence enzyme, the conformation of ferrocytochrome a is affected.
D Sherman, S R Lynch, R A Copeland
openaire   +3 more sources

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Transcriptional Profiles of Secondary Metabolite Biosynthesis Genes and Cytochromes in the Leaves of Four Papaver Species

Data, 2018
Poppies are well-known plants in the family Papaveraceae that are rich in alkaloids. This family contains 61 species, and in this study we sequenced the transcriptomes of four species’ (Papaver rhoeas, Papaver nudicaule, Papaver fauriei, and ...
Dowan Kim, Myunghee Jung, In Jin Ha, Min Young Lee, Seok-Geun Lee, Younhee Shin, Sathiyamoorthy Subramaniyam, Jaehyeon Oh   +7 more
doaj   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

The interplay between tubulins and P450 cytochromes during Plasmodium berghei invasion of Anopheles gambiae midgut. [PDF]

PLoS ONE, 2011
BACKGROUND: Plasmodium infection increases the oxidative stress inside the mosquito, leading to a significant alteration on transcription of Anopheles gambiae detoxification genes.
Rute C Félix, Henrique Silveira
doaj   +1 more source