Results 91 to 100 of about 127,689 (285)

IL-2 stimulated but not unstimulated NK cells induce selective disappearance of peripheral blood cells: concomitant results to a phase I/II study

, 2011
In an ongoing clinical phase I/II study, 16 pediatric patients suffering from high risk leukemia/tumors received highly purified donor natural killer (NK) cell immunotherapy (NK-DLI) at day (+3) +40 and +100 post haploidentical stem cell transplantation.
Claudia Brehm, Bader Peter, Soerensen, Jan, Klingebiel Thomas, Seidl, Christian, Christian Seidl, Petra S. A. Becker, Bremm Melanie, Koehl Ulrike, Becker, Petra S. A., Jakob R. Passweg, Sabine Huenecke, Andrea Quaiser, Peter Bader, Koehl, Ulrike, Thomas Klingebiel, Ulrike Koehl, Jakob R Passweg, Brehm Claudia, Jan Soerensen, Hermann Kreyenberg, Schwabe Dirk, Becker Petra S. A., Brehm, Claudia, Quaiser, Andrea, Petra S A Becker, Bader, Peter, Sörensen, Jan, Mühl Heiko, Stephan Kloess, Huenecke, Sabine, Mühl, Heiko, Klingebiel, Thomas, Esser Ruth, Klöß, Stephan, Esser, Ruth, Hünecke, Sabine, Kloess, Stephan, Huenecke Sabine, Kreyenberg Hermann, Seidl Christian, Melanie Bremm, Kreyenberg, Hermann, Bremm, Melanie, Heiko Mühl, Ruth Esser, Dirk Schwabe, Soerensen Jan, Köhl, Ulrike, Quaiser Andrea, Passweg, Jakob R., Schwabe, Dirk, Kloess Stephan, Passweg Jakob R.   +53 more
core   +1 more source

Evolution of cell therapy for renal cell carcinoma

Molecular Cancer
Treatment for renal cell carcinoma (RCC) has improved dramatically over the last decade, shifting from high-dose cytokine therapy in combination with surgical resection of tumors to targeted therapy, immunotherapy, and combination therapies.
Yufei Wang, Eloah Rabello Suarez, Gabriella Kastrunes, Najla Santos Pacheco de Campos, Rabia Abbas, Renata Schmieder Pivetta, Nithyassree Murugan, Ghanbar Mahmoodi Chalbatani, Vincent D’Andrea, Wayne A. Marasco   +9 more
doaj   +1 more source

Critical Contribution of NK Group 2 Member D Expressed on Invariant Natural Killer T Cells in Concanavalin A-Induced Liver Hepatitis in Mice

Frontiers in Immunology, 2018
Natural killer group 2D (NKG2D) is a well-characterized activating receptor expressed on many immune cells, including invariant natural killer T (iNKT) cells. These cells were shown to be responsible of liver injury in the model of concanavalin A (Con A)-
Dina Al Dulaimi, Dina Al Dulaimi, Jihene Klibi, Jihene Klibi, Veronica Olivo Pimentel, Veronica Olivo Pimentel, Veronique Parietti, Veronique Parietti, Matthieu Allez, Matthieu Allez, Antoine Toubert, Antoine Toubert, Kamel Benlagha, Kamel Benlagha   +13 more
doaj   +1 more source

From Lab to Landscape: Environmental Biohybrid Robotics for Ecological Futures

Advanced Robotics Research, EarlyView.
This Perspective explores environmental biohybrid robotics, integrating living tissues, microorganisms, and insects for operation in real‐world ecosystems. It traces the leap from laboratory experiments to forests, wetlands, and urban environments and discusses key challenges, development pathways, and opportunities for ecological monitoring and ...
Miriam Filippi
wiley   +1 more source

Characterisation of CD8neg and CD8+ human natural killer cell subsets [PDF]

, 2012
NK cells are CD3neg CD56+ lymphocytes that constitute about 10-15% of peripheral blood lymphocytes. They have an innate ability to recognise and kill virus infected cells and tumour cells.
Abdalla, Ibrahim.I.I.
core  

Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal, Milan Patra, Rianita Mondal, Shubhasis Haldar   +3 more
wiley   +1 more source

Spontaneous and cytokine induced natural killer cytotoxicity in patients with Cushing´s disease [PDF]

, 2003
Patients with endogenous hypercortisolism are prone to develop infectious diseases. In this study, we investigated the spontaneous and in vitro response to interleukin-2 (LAK) or interferon -a (IFN-a NK) natural  killer cytotoxicity in 12 ambulatory ...
Goldberg, Victoria, Cardoso, Estela M. del Luján, Arregger, Alejandro Luis, Estrada, Gabriela Margarita, Ofner, Luis M., Contreras, Liliana Noemí   +5 more
core   +1 more source

Spatiotemporal Sequential Delivery of Chidamide Regulates Macrophage Reprogramming in Lymphoma Microenvironment Through HDACs‐STAT3 Pathway

Advanced Science, EarlyView.
Our study identifies the HDACs‐STAT3 axis as key regulator for M2 macrophage accumulation in DLBCL. We developed Chid@M2pep‐EVs/TP, a pH‐responsive drug delivery system for M2 macrophage specific chidamide administration. By coupling M2‐targeted chidamide with EVs‐mediated delivery, this system reprograms M2 to M1 via HDAC inhibition and STAT3 ...
Bo Dai, Shuo Wang, Xiaotong Peng, Kunpeng Wu, Mengyao Wu, Zhaoning Lu, Haoshu Zhong, Xiaohan Qian, Shuiyi Tan, Hui Yang, Tanlezi Sun, Jing Wang, Jie Zhang, Hua Jiang, Yin Tong, Tong Chen   +15 more
wiley   +1 more source

Interleukin-18 [PDF]

, 2003
Interleukin-18 (IL-18), a recently described member of the IL-1 cytokine superfamily, is now recognized as an important regulator of innate and acquired immune responses.
McInnes, I.B., Robertson, S.E., Gracie, J.A.   +2 more
core   +1 more source

High Humidity Exacerbates Psoriasiform Skin Disease Relapse by Increasing Tissue‐Resident Memory T Cells via Altering Skin Microbiota

Advanced Science, EarlyView.
We demonstrated that high humidity worsened psoriasis relapse in murine psoriasiform skin inflammation by increasing skin‐resident memory CD8+ cells via upregulating IL‐15Rα on keratinocytes. The increases in IL‐15Rα and memory CD8+ cells were attributed to S. nepalensis and its metabolite ADMA in skin exposed to high humidity.
Chun‐Ling Liang, Yuchao Chen, Chuanjian Lu, Huazhen Liu, Fenglian Qin, Sisi Dai, Feifei Qiu, Haiming Chen, Weihui Lu, Jonathan S. Bromberg, Zhenhua Dai   +10 more
wiley   +1 more source