Results 71 to 80 of about 127,689 (285)

Cell-based Immunotherapy for Colorectal Cancer with Cytokine-induced Killer Cells [PDF]

Immune Network, 2016
Colorectal cancer is the third leading cancer worldwide. Although incidence and mortality of colorectal cancer are gradually decreasing in the US, patients with metastatic colorectal cancer have poor prognosis with an estimated 5-year survival rate of less than 10%.
Kim, Ji Sung, Kim, Yong Guk, Park, Eun Jae, Kim, Boyeong, Lee, Hong Kyung, Hong, Jin Tae, Kim, Youngsoo, Han, Sang-Bae   +7 more
openaire   +2 more sources

Phenotypic characterization and anticancer capacity of CD8+ cytokine-induced killer cells after antigen-induced expansion. [PDF]

PLoS ONE, 2017
Cytokine-induced killer cells (CIK) have been used in clinic for adoptive immunotherapy in a variety of malignant tumors and have improved the prognosis of cancer patients.
Jianhua Liu, Lu Wang, Yaoling Wang, Wenjie Zhang, Yilin Cao   +4 more
doaj   +1 more source

Skin TLR7 triggering promotes accumulation of respiratory dendritic cells and natural killer cells. [PDF]

, 2012
The TLR7 agonist imiquimod has been used successfully as adjuvant for skin treatment of virus-associated warts and basal cell carcinoma. The effects of skin TLR7 triggering on respiratory leukocyte populations are unknown.
Lohmeyer, Jürgen, Werner von Wulffen (141047), Gruber, Achim D., Gregor Bein (141053), Knoche, Angela, Kershaw, Olivia, Kranz, Sabine, Angela Knoche (141037), Holger Hackstein (141030), Hagel, Nicole, Angela Knoche, Wulffen, Werner von, Olivia Kershaw (141049), Holger Hackstein, Olivia Kershaw, Achim D. Gruber (141051), Nicole Hagel, Gregor Bein, Jürgen Lohmeyer, Sabine Kranz, Nicole Hagel (141033), Baal, Nelli, Bein, Gregor, Achim D Gruber, Jürgen Lohmeyer (141044), Nelli Baal (141055), Hackstein, Holger, Nelli Baal, Werner von Wulffen, Sabine Kranz (141040)   +29 more
core   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

The effect of serum origin on cytokines induced killer cell expansion and function

BMC Immunology, 2023
Abstract Background Cytokine-induced killer (CIK) cells have shown promising results in adoptive immunotherapy. However, serum may play a determining role in the large-scale expansion of these cells for clinical applications.
Zahra Jabbarpour, Seyed Sajjad Aghayan, Kobra Moradzadeh, Sasan Ghaffari, Naser Ahmadbeigi   +4 more
openaire   +3 more sources

Effect of nutrient deficiencies on in vitro Th1 and Th2 cytokine response of peripheral blood mononuclear cells to Plasmodium falciparum infection. [PDF]

, 2010
BACKGROUND: An appropriate balance between pro-inflammatory and anti-inflammatory cytokines that mediate innate and adaptive immune responses is required for effective protection against human malaria and to avoid immunopathology.
Veenemans, J., Chilongola, Jaffu O, Veenemans, Jacobien, Meijerink, M., Mbugi Erasto V, Huub FJ Savelkoul, Shao John F, Meijerink Marjolein, Savelkoul, H.F.J., Savelkoul, Huub FJ, Hans Verhoef, Matthew McCall, Jaffu O Chilongola, Olomi, Raimos M, McCall Matthew, Raimos M Olomi, Veenemans Jacobien, Shao, J.F., Mbugi, Erasto V, McCall, Matthew, Jeurink, P.V., McCall, M., Verhoef, H., Marjolein Meijerink, Verhoef Hans, Savelkoul, H.F., Chilongola Jaffu O, Erasto V Mbugi, Savelkoul Huub FJ, Chilongola, J.O., John F Shao, Jeurink, Prescilla V, Shao, John F, Olomi, R.M., Jeurink Prescilla V, Mbugi, E.V., Jacobien Veenemans, Verhoef, Hans, Chilongola, J., Meijerink, Marjolein, Olomi Raimos M, Prescilla V Jeurink   +41 more
core   +1 more source

Autologous cytokine-induced killer cell transfusion increases overall survival in advanced pancreatic cancer

Journal of Hematology & Oncology, 2016
Background Advanced pancreatic cancer (PC) has very poor prognosis with present treatments, thus necessitating continued efforts to find improved therapeutic approaches. Both preclinical and preliminary clinical data indicate that cytokine-induced killer
Zibing Wang, Yuqing Liu, Rui’e Li, Yiman Shang, Yong Zhang, Lingdi Zhao, Wei Li, Yonghao Yang, Xiaojie Zhang, Tiejun Yang, Changfu Nie, Feng Han, Ying Liu, Suxia Luo, Quanli Gao, Yongping Song   +15 more
doaj   +1 more source

Swelling‐Programmed Topographical Guidance for Dynamic Spheroid Self‐Assembly via a Mechanochemical Hydrogel Niche

Advanced Functional Materials, EarlyView.
A swelling‐programmed micropatterned hydrogel guides adherent cells through a controlled transition from cell–matrix anchoring to cadherin‐mediated cell–cell compaction, enabling rapid assembly of high‐viability spheroids with defined size and morphology.
Han Gyeol Nam, Seon Yeong Chae, Young Woo Kwon, Hye Jin Heo, Hye Rin Lee, Ji Hyeok Lee, Dong‐Wook Han, Yun Hak Kim, Suck Won Hong   +8 more
wiley   +1 more source

The activating receptors 2B4 and NTB-A, but not CRACC are subject to ligand-induced down-regulation on human natural killer cells

, 2010
Activation of natural killer cells can be mediated by different receptors. Stimulation of the receptors 2B4, NTB-A and CRACC, members of the SLAM-related receptor family, induces cytotoxicity and cytokine production.
Stephan Meinke, Carsten Watzl, Carolin Böhm, Sibel Durlanik, Carolin Böhm   +4 more
core   +1 more source

Photothermal‐Activated Antibacterial Amyloid‐Polyphenol‐Iron Hydrogels for Synergistic Wound Healing

Advanced Healthcare Materials, EarlyView.
We report a thermally triggered supramolecular hydrogel (LTFe) formed by Fe3+ and tannic acid on lysozyme amyloid fibrils. Fe3+ enables rapid gelation and photothermal transduction with an efficiency of 88.56%. The LTFe hydrogel exhibits excellent biocompatibility, potent antibacterial activity against E. coli and S.
Di Wu, Jiangtao Zhou, Yang Shen, Qiyao Sun, Tong Li, Xiaoyang Zou, Bin Liu, Hongshan Liang, Raffaele Mezzenga   +8 more
wiley   +1 more source