Results 51 to 60 of about 3,672,235 (286)

The efficacy and safety of the combination of axitinib and pembrolizumab‐activated autologous DC‐CIK cell immunotherapy for patients with advanced renal cell carcinoma: a phase 2 study

Clinical & Translational Immunology, 2021
Objectives Although axitinib has achieved a preferable response rate for advanced renal cell carcinoma (RCC), patient survival remains unsatisfactory. In this study, we evaluated the efficacy and safety of a combination treatment of axitinib and a low ...
Meng‐Jia Song, Qiu‐Zhong Pan, Ya Ding, Jianxiong Zeng, Pei Dong, Jing‐Jing Zhao, Yan Tang, Jingjing Li, Zhiling Zhang, Junyi He, Jieying Yang, Yue Huang, Ruiqing Peng, Qi‐Jing Wang, Jia‐Mei Gu, Jia He, Yong‐Qiang Li, Shi‐Ping Chen, Rongxing Huang, Zi‐Qi Zhou, Chaopin Yang, Yulong Han, Hao Chen, Heping Liu, Shangzhou Xia, Yang Wan, De‐Sheng Weng, Liming Xia, Fang‐Jian Zhou, Jian‐Chuan Xia   +29 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Researche Advances on CIK Cells and Their Clinical Use in Lung Cancer

Chinese Journal of Lung Cancer, 2011
As the leading cause of cancer-related death among human beings, lung cancer seriously threats peoples’ health all over the world. Cytokine-induced killer cells (CIK) is a new kind of adaptive immune cells characterized by its dramatic proliferation ...
Hu LUO, Xiangdong ZHOU
doaj   +1 more source

Stress-induced in vivo recruitment of human cytotoxic natural killer cells favors subsets with distinct receptor profiles and associates with increased epinephrine levels [PDF]

, 2015
Acute stress drives a 'high-alert' response in the immune system. Psychoactive drugs induce distinct stress hormone profiles, offering a sought-after opportunity to dissect the in vivo immunological effects of acute stress in humans.
Recher, Mike, Egli, Simon B., Marc B Bigler, Simon B Egli, Fabian S. Baldin (839693), Marc B. Bigler (839689), Florian A. Marquardsen (839694), Baldin, Fabian S., Schmied, Laurent, Cédric M Hysek, Christoph T. Berger, Laurent Schmied, Cédric M. Hysek (166535), Laurent Schmied (839692), Christoph T. Berger (189490), Gideon Hoenger (839691), Liechti, Matthias E., Simon B. Egli (839690), Christoph Hess, Fabian S Baldin, Matthias E Liechti, Marc B. Bigler, Cédric M. Hysek, Mike Recher, Hysek, Cédric M., Hess, Christoph, Berger, Christoph T., Christoph Hess (178783), Marquardsen, Florian A., Christoph T Berger, Hoenger, Gideon, Matthias E. Liechti (166584), Simon B. Egli, Gideon Hoenger, Fabian S. Baldin, Florian A Marquardsen, Mike Recher (36073), Matthias E. Liechti, Bigler, Marc B., Florian A. Marquardsen, Hess C, Hysek Cédric M., Egli SB, Hysek CM, Hoenger G, Schmied Laurent, Berger Christoph T., Hoenger Gideon, Liechti ME, Recher Mike, Egli Simon B., Baldin FS, Liechti Matthias E., Bigler Marc B., Schmied L, Recher M, Berger CT, Baldin Fabian S., Marquardsen Florian A., Hess Christoph, Bigler MB, Marquardsen FA   +61 more
core   +1 more source

Cytokine-induced killer cell/dendritic cell–cytokine-induced killer cell immunotherapy for the postoperative treatment of gastric cancer

Medicine, 2018
Immunotherapy is emerging as a new treatment strategy for gastric cancer(GC). However, the efficacy and safety of this technique remain unclear. This meta-analysis aimed to assess the effect of cytokine-induced killer cell (CIK)/dendritic cell-cytokine-induced killer cell (DC-CIK) treatment for GC after surgery.Hazard ratio (HR), overall survival (OS ...
Wang, Xiang, Tang, Song, Cui, Xiang, Yang, Jinwei, Geng, Chunyu, Chen, Cong, Zhou, Ning, Li, Yumin   +7 more
openaire   +2 more sources

Cytokine-Induced Killer Cells Eradicate Bone and Soft-Tissue Sarcomas [PDF]

Cancer Research, 2014
AbstractUnresectable metastatic bone sarcoma and soft-tissue sarcomas (STS) are incurable due to the inability to eradicate chemoresistant cancer stem–like cells (sCSC) that are likely responsible for relapses and drug resistance. In this study, we investigated the preclinical activity of patient-derived cytokine-induced killer (CIK) cells against ...
SANGIOLO, Dario, Mesiano G, Gammaitoni L, Leuci V, Todorovic M, Giraudo L, Cammarata C, Dell'aglio C, D'Ambrosio L, Pisacane A, Sarotto I, Miano S, FERRERO, Ivana, Carnevale Schianca F, PIGNOCHINO, YMERA, Sassi F, BERTOTTI, Andrea, PIACIBELLO, Vanda, Fagioli F, AGLIETTA, Massimo, Grignani G.   +20 more
openaire   +4 more sources

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Functional invariant natural killer T-cell and CD1d axis in chronic lymphocytic leukemia: implications for immunotherapy

Haematologica, 2013
Invariant natural killer T cells recognize glycolipid antigens such as α-galactosylceramide presented by CD1d. In preclinical models of B-cell malignancies, α-galactosylceramide is an adjuvant to tumor vaccination, enhancing tumor-specific T-cell ...
Robert Weinkove, Collin R. Brooks, John M. Carter, Ian F. Hermans, Franca Ronchese   +4 more
doaj   +1 more source

Clinical Studies on Cytokine-Induced Killer Cells: Lessons from Lymphoma Trials [PDF]

, 2021
Cancer is a complex disease where resistance to therapies and relapses often pose a serious clinical challenge. The scenario is even more complicated when the cancer type itself is heterogeneous in nature, e.g., lymphoma, a cancer of the lymphocytes ...
Weiher, Hans, Amit Sharma, Ingo G. H. Schmidt-Wolf, Sharma, Amit, Ying Zhang, Matthias Schmid, Glen Kristiansen, Zhang, Ying, Schmidt-Wolf, Ingo G. H., Kristiansen, Glen, Schmid, Matthias, Hans Weiher   +11 more
core   +1 more source

Cytokine-induced killer cells/dendritic cells and cytokine-induced killer cells immunotherapy for the treatment of esophageal cancer in China: a meta-analysis

OncoTargets and Therapy, 2017
Immunotherapy based on cytokine-induced killer cells or combination of dendritic cells and cytokine-induced killer cells (CIK/DC-CIK) showed promising clinical outcomes for treating esophageal cancer (EC). However, the clinical benefit varies among previous studies.
Yan Liu, Ying Mu, Anqi Zhang, Shaoda Ren, Weihua Wang, Jiaping Xie, Yingxin Zhang, Changhui Zhou   +7 more
openaire   +4 more sources